Current hypotheses on synergistic microbial gangrene

Kingston, David G. I.; Seal, D.V.

doi:10.1002/bjs.1800770309

Cited by 84 publications

(32 citation statements)

References 66 publications

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“…According to Bowler and Davies (1999) there is a greater diversity of microorganisms in infected leg ulcers than in non-infected leg ulcers. These observations support the view of Kingston and Seal (1990), who argued that all species associated with a microbial disease should be considered potentially synergistic. This indicates that microbial interactions may induce an enhanced pathogenic effect (Bello et al, 2001).…”

Section: Chronic Woundssupporting

confidence: 86%

Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process

Bohova¹,

Majtán²,

Takáč³

2012

TANG [HUMANITAS MEDICINE]

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The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

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Section: Chronic Woundssupporting

confidence: 86%

Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process

Bohova¹,

Majtán²,

Takáč³

2012

TANG [HUMANITAS MEDICINE]

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“…in the others. Potentiation of infection by microbial synergistic partnerships between aerobes, such as S. aureus and S. pyogenes, and nonsporing anaerobes has been recognized in various types of nonclostridial cellulitis and necrotizing fasciitis (40,122).…”

Section: Wound Infectionmentioning

confidence: 99%

Wound Microbiology and Associated Approaches to Wound Management

2001

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The majority of dermal wounds are colonized with aerobic and anaerobic microorganisms that originate predominantly from mucosal surfaces such as those of the oral cavity and gut. The role and significance of microorganisms in wound healing has been debated for many years. While some experts consider the microbial density to be critical in predicting wound healing and infection, others consider the types of microorganisms to be of greater importance. However, these and other factors such as microbial synergy, the host immune response, and the quality of tissue must be considered collectively in assessing the probability of infection. Debate also exists regarding the value of wound sampling, the types of wounds that should be sampled, and the sampling technique required to generate the most meaningful data. In the laboratory, consideration must be given to the relevance of culturing polymicrobial specimens, the value in identifying one or more microorganisms, and the microorganisms that should be assayed for antibiotic susceptibility. Although appropriate systemic antibiotics are essential for the treatment of deteriorating, clinically infected wounds, debate exists regarding the relevance and use of antibiotics (systemic or topical) and antiseptics (topical) in the treatment of nonhealing wounds that have no clinical signs of infection. In providing a detailed analysis of wound microbiology, together with current opinion and controversies regarding wound assessment and treatment, this review has attempted to capture and address microbiological aspects that are critical to the successful management of microorganisms in wounds

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“…though the isolate was sensitive to ampicloxacillin, metronidazole was included in the regimen to suppress the population of indigenous anaerobic bacteria with the propensity to produce large amount of β-lactamases to which ampicloxacillin is susceptible. Clostridium perfringens has been described together with S. aureus as a leading pathogen in necrotising soft tissue infections (17,18).…”

Section: Discussionmentioning

confidence: 99%

Bacteriological And Clinical Evaluation Of Twelve Cases Of Post-Surgical Sepsis Of Odontogenic Tumours At A Referral Centre

Egwari

Nwokoye²,

Obisesan³

et al. 2008

E Af Med Jrnl

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E a s t a f r i c a n M E d i c a l J o u r n a l 269 most, of which are odontogenic in origin (1,2). While there is a uniform consensus to surgery as the cornerstone for the treatment of tumours and carcinomas (1,3) with radiotherapy indicated 6.5%, Prevotella melaninogenica 3.2%, Clostridium perfringens 3.2%). mixed aerobic and anaerobic aetiology occurred more in osteosarcoma and fibrosarcoma. Clostridium perfringens was isolated from a case of osteosarcoma with necrotic tissues. the anaerobic bacteria were 100% sensitive to metronidazole, ciprofloxacin and augmentin, 65-85% sensitivity to ampicloxacillin, amoxicillin and erythromycin. over 92% of the streptococci were sensitive to the β-lactams contrast low susceptibility with s. aureus and K. pneumoniae. Conclusion: Interruption of healthcare service was the sole factor identified in the development of sepsis as the patients could not be monitored to ensure compliance to prescription.

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Current hypotheses on synergistic microbial gangrene

Cited by 84 publications

References 66 publications

Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process

Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process

Wound Microbiology and Associated Approaches to Wound Management

Bacteriological And Clinical Evaluation Of Twelve Cases Of Post-Surgical Sepsis Of Odontogenic Tumours At A Referral Centre

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