Current guidelines for the evaluation and management of atopic dermatitis – A comparison of the Joint Task Force Practice Parameter and American Academy of Dermatology Guidelines

Eichenfield, Lawrence F.; Ahluwalia, Jusleen; Waldman, Andrea; Borok, Jenna; Udkoff, Jeremy; Boguniewicz, Mark

doi:10.1016/j.alergo.2017.11.001

Cited by 40 publications

(90 citation statements)

References 8 publications

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“…Use of moisturisers is considered as an effective way to prevent transepidermal water loss (TEWL), prevent flare‐ups and reduce the need for pharmacologic treatment. Bathing for AD patients can be double‐edged: it removes crusts, irritants, allergens and bacterial plaques, but at the same time poses further challenges to epidermal barrier integrity …”

Section: Introductionmentioning

confidence: 99%

“…Bathing for AD patients can be double-edged: it removes crusts, irritants, allergens and bacterial plaques, but at the same time poses further challenges to epidermal barrier integrity. 1 The development of moisturising body wash products is one of the more significant changes to affect the personal cleansing market in recent years. 2 A key factor contributing to the popularity of these products is that the advanced body wash technologies can be designed to deliver better skin care benefits than regular cleansing body washes or mild bat soaps.…”

Section: Introductionmentioning

confidence: 99%

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Skin benefits of moisturising body wash formulas for children with atopic dermatitis: A randomised controlled clinical study in China

Liu

Niu³

et al. 2019

Aust J Dermatology

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Background It acknowledged that skin care is an important part of atopic dermatitis therapy. However, clinical evidences are limited for the best bathing practices, especially the skin health performance of cleansing products on children's atopic dermatitis skin. Methods A randomised controlled clinical study was conducted in China among 4‐ to 18‐year‐old children with mild‐to‐moderate atopic dermatitis to evaluate the skin health effect of three cleansing systems (a mild synthetic bar, an ultra‐mild body wash with lipids, and an ultra‐mild body wash with lipids and zinc pyrithione) by measuring SCORing of Atopic Dermatitis (SCORAD), consumption of topical corticosteroid and the characteristics of microbiome. Results Increased Staphylococcus aureus abundance and decreased microbial diversity were observed in atopic dermatitis lesion sites compared with healthy control sites. After 4 weeks of treatment, all three treatments showed clinically important improvement from baseline in SCORAD. Four‐week corticosteroid consumption was significantly lower for the two body wash groups than the bar group. A significant decrease in S. aureus abundance and increase in microbial diversity were observed in the lesion sites for the two body wash formulas, while the microbial diversity was statistically insignificant for the mild cleansing bar group. However, there were no incremental benefits provided by the body wash formulas based on the assessment of SCORAD. Conclusions These results demonstrated the safety and efficacy of using the investigational body wash formulas with lipids in reducing the needs for corticosteroid and improving the healthy composition of skin microbiome vs. the mild synthetic bar soap.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skin benefits of moisturising body wash formulas for children with atopic dermatitis: A randomised controlled clinical study in China

Liu

Niu³

et al. 2019

Aust J Dermatology

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“…SCORAD was reduced from a median of 34.9 [interquartile range 28.75-45.15] at Baseline to 17.2 [12.95-32.3] at the final visit, and IGA improved significantly from 4 [3-4] to 2 [1-3]. We observed a significant improvement in .0] to 12 [8][9][10][11][12][13][14][15][16][17][18], P = .023) and DFI (P = .011), but not CDQLI or POEM. Compared to 6-month period prior to enrolment, there was a significant reduction at six months after the start of the intervention in potent topical corticosteroids (P = .033).…”

mentioning

confidence: 77%

“…Compared to Visit 1, FDQLI at Visit 12 was significantly lower (16.0 [12.25-19.0] to 12 [8][9][10][11][12][13][14][15][16][17][18], P = .02), suggesting improvement, as did DFI (P = .01). Figure S3 shows data on medication use and healthcare utilization.…”

Section: Secondary End-pointsmentioning

confidence: 94%

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Temperature‐controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open‐label, proof‐of‐concept study

Gore

Fontanella

et al. 2018

Clin Experimental Allergy

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Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

Karamali

Shafabakhsh

Ghanbari

et al. 2019

Journal Cellular Physiology

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Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder inflammation that leads to chronic bladder pain and urinary urgency and frequency. The presentation of IC/PBS is heterogeneous, and it is classified as ulcerative IC/PBS and nonulcerative IC/PBS. The main cause of IC/PBS is thought to be a persistent inflammatory condition in the bladder, though the actual pathophysiology has not been identified yet. Although the underlying pathophysiology of IC/PBS is not completely understood, several theories for the etiology of this syndrome have been suggested, including deficiency of the glycosaminoglycan covering urothelium surface that results in leaky urothelium infection, immunological etiology, activated mast cells, neural changes, and inflammation. In addition, there are no gold standards for the detection of this disorder to date. So, determination of gene expression and its role in different signaling pathways in the pathogenesis of this heterogeneous disorder contribute to the more efficient cognition of the pathophysiology of this disease and to the design of effective treatments and molecular diagnostic methods for IC/PBS.

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Current guidelines for the evaluation and management of atopic dermatitis – A comparison of the Joint Task Force Practice Parameter and American Academy of Dermatology Guidelines

Cited by 40 publications

References 8 publications

Skin benefits of moisturising body wash formulas for children with atopic dermatitis: A randomised controlled clinical study in China

Skin benefits of moisturising body wash formulas for children with atopic dermatitis: A randomised controlled clinical study in China

Temperature‐controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open‐label, proof‐of‐concept study

Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

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