Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens

Gilani, Saad; Chrystal, Peter V.; Barekatain, Reza

doi:10.1016/j.aninu.2021.03.001

Cited by 28 publications

(21 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intestinal barrier dysfunction can be induced by various physiological or nutritional factors [11]. One such model is through the use of dexamethasone (DEX), a synthetic glucocorticoid (GC) that causes increased intestinal permeability, differential expression of tight junction proteins, and increased inflammation [12].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Barekatain

Chalvon‐Demersay

McLaughlan

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

Two experiments were conducted to investigate the effect of arginine (Arg); the combination of Arg and glutamine (Gln); as well as an amino acid-based solution (MIX) containing Arg, Gln, threonine (Thr), and grape extract, on performance, intestinal permeability, and expression of selected mechanistic genes. Using 240 male Ross 308 off-sex broiler chickens, four experimental treatments were replicated six times with 10 birds per replicate. The experimental treatments included 5 g/kg Arg, 2.5 g/kg Arg and 2.5 g/kg Gln, and 1 g/kg MIX added to a basal diet as control. In the second study, the four dietary treatments were then given to 24 birds with or without a synthetic glucocorticoid, dexamethasone (DEX), as a gut dysfunction model. Feed conversion ratio was improved by all the supplemented treatments from day 7 to 35 of age (p < 0.001). DEX injections increased (p < 0.001) the intestinal permeability in all treatments, which tended to be reversed by Arg or MIX. Additional Arg, Arg-Gln, and MIX suppressed (p < 0.05) the overexpression of IL-1β generated by DEX. Feeding birds with MIX treatment increased (p < 0.05) expression of SGLT-1 and glutathione synthetase. In conclusion, tested amino acid supplements were effective in improving feed efficiency and restraining intestinal inflammation caused by DEX through IL-1β pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Barekatain

Chalvon‐Demersay

McLaughlan

et al. 2021

Animals

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, these processes lead to an increase in intestinal permeability [45,46]. Thus, leaky gut syndrome develops as a response to pathogens, feed deprivation, and stress [47][48][49][50].…”

Section: Intestinal Barrier and Tight Junctionsmentioning

confidence: 99%

Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry

et al. 2022

View full text Add to dashboard Cite

The gut microbiota has been designated as a hidden metabolic ‘organ’ because of its enormous impact on host metabolism, physiology, nutrition, and immune function. The connection between the intestinal microbiota and their respective host animals is dynamic and, in general, mutually beneficial. This complicated interaction is seen as a determinant of health and disease; thus, intestinal dysbiosis is linked with several metabolic diseases. Therefore, tractable strategies targeting the regulation of intestinal microbiota can control several diseases that are closely related to inflammatory and metabolic disorders. As a result, animal health and performance are improved. One of these strategies is related to dietary supplementation with prebiotics, probiotics, and phytogenic substances. These supplements exert their effects indirectly through manipulation of gut microbiota quality and improvement in intestinal epithelial barrier. Several phytogenic substances, such as berberine, resveratrol, curcumin, carvacrol, thymol, isoflavones and hydrolyzed fibers, have been identified as potential supplements that may also act as welcome means to reduce the usage of antibiotics in feedstock, including poultry farming, through manipulation of the gut microbiome. In addition, these compounds may improve the integrity of tight junctions by controlling tight junction-related proteins and inflammatory signaling pathways in the host animals. In this review, we discuss the role of probiotics, prebiotics, and phytogenic substances in optimizing gut function in poultry.

show abstract

“…(iv) During dysbiosis, LPS production by Gram-negative bacteria is increased and induces local and systematic inflammation by the stimulation of the intestinal epithelial cells and macrophages. As a result, tight junctions are damaged, leading to leaky gut syndrome [ 94 , 95 , 96 , 97 , 98 , 99 ].…”

Section: Factors For Oxidative Stress and Inflammation In Poultry: Se...mentioning

confidence: 99%

Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects

Basiouni

Téllez-Isaías

Latorre

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

Chronic stress is recognized as a secret killer in poultry. It is associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative stress reactions that damage the barrier function of the cells lining the gut wall. Poultry, especially the genetically selected broiler breeds, frequently suffer from these chronic stress symptoms when exposed to multiple stressors in their growing environments. Since oxidative stress reactions and inflammatory damages are multi-stage and long-term processes, overshooting immune reactions and their down-stream effects also negatively affect the animal’s microbiota, and finally impair its performance and commercial value. Means to counteract oxidative stress in poultry and other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids and phenolic compounds, are known to exert anti-inflammatory and antioxidant effects. In this review, firstly, the main stressors in poultry, such as heat stress, mycotoxins, dysbiosis and diets that contain oxidized lipids that trigger oxidative stress and inflammation, are discussed, along with the key transcription factors involved in the related signal transduction pathways. Secondly, the most promising phytogenic substances and their current applications to ameliorate oxidative stress and inflammation in poultry are highlighted.

show abstract

Current experimental models, assessment and dietary modulations of intestinal permeability in broiler chickens

Cited by 28 publications

References 93 publications

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry

Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects

Contact Info

Product

Resources

About