Current directions in co-crystal growth

Blagden, Nicholas; Berry, David J.; Parkin, Aandrew; Javed, Hafsa; Ibrahim, Asim Y.; Gavan, Pauline T.; Matos, Luciana L. De; Seaton, Colin C.

doi:10.1039/b803866j

Cited by 146 publications

(125 citation statements)

References 97 publications

(36 reference statements)

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“…Other factors which may have an impact include the dissolution medium favouring the combinations with specific coformers, particle size, wettability and possible tablet surface recrystallisation affecting drug release. [52][53][54] The solubility and dissolution experiments suggest that only one cocrystal (that with HQ)…”

Section: Resultsmentioning

confidence: 99%

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Mapp

Coles

Aitipamula

2016

Crystal Growth & Design

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ABSTRACT:We report eight new cocrystals with an analgesic drug, propyphenazone, which belongs to a family of compounds that possess limited or no hydrogen bonding functionality. Such molecules 2 present difficulties in predicting and selecting appropriate coformers for potential multicomponent systems, and current prediction methodologies are unsuitable due to their focus around hydrogen bonding. This study used a knowledge-based strategy to identify appropriate coformers as well as testing a wide variety of molecules to confirm the initial predictions. All new cocrystals were characterized using X-ray diffraction techniques as well as measuring their physiochemical properties. These included the thermal behavior, stability under slurry and accelerated conditions, solubility and dissolution rate and were compared with the parent propyphenazone. It was found that while the stability of most of the cocrystals and propyphenazone was comparable, a cocrystal with hydroquinone showed an increase in both the solubility and dissolution rate of propyphenazone.

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Section: Resultsmentioning

confidence: 99%

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Mapp

Coles

Aitipamula

2016

Crystal Growth & Design

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“…Co-crystal is one of the crystalline materials including di erent molecular species held together by non-covalent forces in which all components are solid under ambient conditions when in their pure form [1][2][3]. Some of them exhibit encouraging potential for application in pharmaceutical science, solid-state organic synthesis and luminescent materials [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 5-(4-pyridyl)pyrimidine–4,4′-bipyridine–1,3,5-benzenetriol–water (1:1:1:1), C₂₅H₂₃N₅O₄

You

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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C 25 H 23 N5O4, triclinic, P¯ (no. 2), a = 8.157(2) Å, b = 9.262(2) Å, c = 15.465(4) Å, α = 87.887(4)°, β = 89.803(4)°, γ = 72.727(4)°, CCDC no.: 1441527The crystal structure is shown in the gure, Tables 1-3 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of materialA dichloromethane solution (5 mL) of 5-(4-pyridyl)pyrimidine (15.7 mg, 0.1 mmol) and 4,4′-bipyridine (15.6 mg, 0.1 mmol) was mixed with an aqueous acetonitrile solution (95%, 5 mL)

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“…The overall motivation for investigating pharmaceutical co-crystals as an alternative approach during drug development is the adjustment of the physiochemical properties to improve the overall stability and efficacy of a dosage form. [33] Physicochemical properties, such as crystallinity, melting point, solubility, dissolution and stability, have been studied extensively by researchers.…”

Section: Physicochemical Properties Of Co-crystalsmentioning

confidence: 99%

Taste Masking by Co-Crystallization: A Review

Dhakate¹

2017

WJPR

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Acceptability of any dosage form mainly depends on its taste i.e. mouth feel. Dosage form interacts with taste receptor on the tongue to give bitter, sweet or salty taste sensation, when it dissolves in saliva. In market, there are numbers of pharmaceutical preparations available in which actives are bitter in taste. Pediatric patients frequently fail to take medications properly because of unpleasant taste of medication.Thus bitterness of preparation leads to patient incompliance. So masking of bitterness becomes essential. To overcome this problem, many technique has been developed to mask the bitter taste of drugs.Co-crystallization involves alteration in molecular assemblies and composition of pharmaceutical substance and which ultimately results in enhancing physical properties. Co-crystals contains API and pharmaceutically acceptable co-formers. Co-crystals are molecular complexes, bringing about changes in solubility, bioavailability, stability and taste masking of bitter drug in pharmaceutical designing without interacting with therapeutic utility. The main objective of this review is discuss co-crystallization as a technique for masking the bitter taste of the drug.

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Current directions in co-crystal growth

Abstract: Bradford Scholars -how to deposit your paper Overview Copyright check• Check if your publisher allows submission to a repository.• Use the Sherpa RoMEO database if you are not sure about your publisher's position or email openaccess@bradford.ac.uk.

Cited by 146 publications

References 97 publications

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Crystal structure of 5-(4-pyridyl)pyrimidine–4,4′-bipyridine–1,3,5-benzenetriol–water (1:1:1:1), C₂₅H₂₃N₅O₄

Taste Masking by Co-Crystallization: A Review

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Current directions in co-crystal growth

Abstract: Bradford Scholars -how to deposit your paper Overview Copyright check• Check if your publisher allows submission to a repository.• Use the Sherpa RoMEO database if you are not sure about your publisher's position or email openaccess@bradford.ac.uk.

Cited by 146 publications

References 97 publications

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System

Crystal structure of 5-(4-pyridyl)pyrimidine–4,4′-bipyridine–1,3,5-benzenetriol–water (1:1:1:1), C25H23N5O4

Taste Masking by Co-Crystallization: A Review

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Crystal structure of 5-(4-pyridyl)pyrimidine–4,4′-bipyridine–1,3,5-benzenetriol–water (1:1:1:1), C₂₅H₂₃N₅O₄