Current Developments on Enamel and Dentin Remineralization

Braga, Roberto Ruggiero; Habelitz, Stefan

doi:10.1007/s40496-019-00242-5

Cited by 9 publications

(6 citation statements)

References 76 publications

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“…One of the goals of modem dentistry is to manage non-cavi- tated white spot lesions and to prevent further disease progression [18]. Fluoride treatment has been demonstrated to re-mineralize white spot lesions, although it is effective in the first 10 to 30 μm of the lesion, necessitating the development of alternate treatments to enable re-mineralization of deeper layers [19]. Re-mineralization of early carious lesions may be accomplished using a range of currently available agents, including BAG, CPP ACP, and nano-hydroxyapatite.…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of electrophoresis-aided re-mineralization on surface topography and chemical composition of de-mineralized enamel: an in vivo animal model study

Ahmed Elmobasher,

Nabih,

Mohamed

2024

jos

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Introduction:The most mineralized and rigid tissue in the human body is tooth enamel. Enamel, the outermost covering of teeth, is made of hydroxyapatite, which is arranged in a well-organized prism structure to absorb loads. De-mineralization occurs when the most widely available and soluble material is removed from the enamel rods' periphery and it is exposed to acids, increasing the enamel's surface porosity, and allowing more acids to diffuse into the tissue and lose mineral ions. Objectives: To evaluate whether an electrophoresis-aided system improved re-mineralization of de-mineralized enamel more than a traditional technique in rabbits with initial enamel lesions using different re-mineralizing agents. Material and methods: Initial enamel lesion was produced through acid etching, and three re-mineralizing agents, such as nano-hydroxyapatite, casein phospho-peptide amorphous calcium phosphate, and bioactive glass, were applied to labial surface using traditional or electrophoresis-aided techniques. Surface topography and chemical composition were evaluated using environmental scanning electron microscope/energy dispersive X-ray spectrometer at baseline, after de-mineralization, and after re-mineralization, at different time periods, such as 2 weeks and 5 weeks for a traditional technique, and 3 hours and 5 hours for an electrophoresis-aided technique. Results: Environmental scanning electron microscope showed that re-mineralizing agents enhanced re-mineralization of surface topography following different application periods. Energy dispersive X-ray spectrometer results revealed that for the traditional technique, there was no statistically significant difference between mean Ca : P ratio values of the three materials at 2 and 5 weeks. For the electrophoresis-aided technique, nanohydroxyapatite showed the highest effect, with the most insignificant effect demonstrated in bioactive glass at both 3 and 5 hours. Conclusions: Applying different re-mineralizing agents significantly influences enamel topography and chemical composition, and accelerate the effect of re-mineralizing agents. Moreover, the dynamics of re-mineralizing agents might be accelerated by electrophoresis.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of electrophoresis-aided re-mineralization on surface topography and chemical composition of de-mineralized enamel: an in vivo animal model study

Ahmed Elmobasher,

Nabih,

Mohamed

2024

jos

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“…The caries-infected dentin mineral distribution is highly variable, and the extension of the lesion depth is hundreds of microns below the excavated surface. The biomimetic treatment of caries-infected tissues involves guiding remineralization, replicating the physiological mechanisms of tissue mineralization (12) . This study was designed to evaluate the remineralizing effect of propolis hesperidin as natural agents and silver diamine fluoride as synthetic agent on deep carious dentin.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Remineralizing Effect of Natural Versus Synthetic Materials on Deep Carious Dentin

Elasser

Niazy²,

jamil³

et al. 2022

ADJ-for Girls

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Purpose :The purpose of this in-vivo study was to investigate the remineralizing effects of natural (propolis, hesperidin) versus synthetic agent (silver diamine fluoride with potassium iodide) after treatment of deep carious dentin at different time intervals. Materials and methods: Patients with deep carious class I lesions were selected according to inclusion and exclusion criteria. Class I carious lesions were randomly distributed into 4 groups according to treatment material: 1. Propolis, 2. Hesperidin, 3.Silver diamine fluoride with potassium iodide (SDF+KI), and 4. Control group (no treatment). Class I cavities were all prepared using step-wise caries removal technique. The treatment materials were then applied on the remaining carious dentin and restored with a glass ionomer (GIC) restoration. Assessment of remineralization was done by measurement of mineral-density of dentin using digital x-ray machine at baseline, 6-weeks and 12-weeks time intervals. Results: Silver diamine fluoride had a higher significant remineralizing effect than control, propolis or hesperidin. While propolis had a higher significant remineralizing effect than hesperidin. Conclusions: Both silver diamine fluoride and propolis agents have remarkable effect on remineralization of carious dental tissues.

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“…These NCPs acts as a key factor in controlling the oriented elongation of enamel rod growth during the mineralization process and responsible for guiding the deposition of hydroxyapatite in its characteristic prismatic structure. These are negatively charged structure that interacts with calcium ions to control the orientation of the growing crystals [9,10]. Remineralization and regeneration of enamel can be possible to a certain extent, by the use of biomimetic template analogues of the natural proteins involved in bio-mineralization [11].…”

Section: Biomimetic Strategy For Enamel Restorationmentioning

confidence: 99%

“…Apatite mineral in dentin needs to be bound to the collagenous matrix or ideally be incorporated into the collagen fibrils to mechanically reinforce the tissue. Thus, processdirecting agents along coupled with NCP analogue on remineralization agents can only induce intrafibrillar mineral deposition in collagen [10].…”

Section: Non-classical Crystallization Pathwaymentioning

confidence: 99%

Future Perspectives of Biomimetics in Restorative Dentistry

Basheer

Madhubala

Mahalaxmi

2020

JPRI

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The main goal of tooth restoration aims at achieving mineralization of initial enamel and dentinal lesions in native form. Most of the restorative materials and remineralization adjuvants for enamel and dentin mineralization are evidenced in the literature. Although commercially available restorative materials exhibit superior esthetics, mechanical properties and cost effectiveness, durability of the restoration threatened by the occurrence of inadequate strength, long-term solubility, and weaker adhesion to tooth and accelerated degradation after being bonded to tooth structure. Recently, the role of biomimetic science in restorative dentistry aims at creating a restoration that can be highly compatible with the structural, functional and biologic properties of dental tissues to reproduce and emulate the original performance of the intact tooth with high durability. In order to recover the prismatic structure in mineral-depleted enamel and to achieve interfibrillar mineralization in dentin, non-collagenous protein analogues have been proposed as templates for apatite deposition. Biomimetic analogues must be necessary to achieve functional mineralization and to recover the dynamic mechanical properties of teeth. The use of these analogues associated with ion-releasing materials seems to be a promising approach for both enamel and dentin remineralization. This review enlightens the current and future perspectives of biomimetic analogues used for enamel and dentin remineralization as the clinical translation of this biomimetic research can be considered as the boon to restorative dentistry.

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Current Developments on Enamel and Dentin Remineralization

Cited by 9 publications

References 76 publications

In vivo evaluation of electrophoresis-aided re-mineralization on surface topography and chemical composition of de-mineralized enamel: an in vivo animal model study

In vivo evaluation of electrophoresis-aided re-mineralization on surface topography and chemical composition of de-mineralized enamel: an in vivo animal model study

Evaluation of the Remineralizing Effect of Natural Versus Synthetic Materials on Deep Carious Dentin

Future Perspectives of Biomimetics in Restorative Dentistry

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