Current development in integrative therapy of traditional Chinese medicine for cancer treatment: A mini-review

Su, Po Hsuan; Tai, Chen Jei

doi:10.1016/j.jtcme.2019.07.001

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Five trials (6, 8, 9, 15, 16) evaluated the tumor by Response Evaluation Criteria in Solid Tumors (RECIST) between two groups. Meta-analysis showed that the pathological change of tumor was significantly more stable in the CHM-WM group when compared with WM group (RR = 1.30, 95% CI: 1.01–1.67, P = 0.04, Figure 2C).…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Chinese Herbal Medicine on Ovarian Cancer After Reduction Surgery and Adjuvant Chemotherapy: A Systematic Review and Meta-Analysis

et al. 2019

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Background: Ovarian cancer (OvC) is a malignant tumor which invades ovarian epithelium and interstitium. Reduction surgery combined with adjuvant chemotherapy is standard treatment for OvC patients, but the adverse effects due to chemotherapy still remains a major problem. While Chinese herbal medicine (CHM) therapy has a unique therapeutic effect to reduce side effects of chemotherapy by boosting immune system, the evidence of CHM in the treatment of OvC patients are limited. Objective: We conducted a systematic review to evaluate the efficacy and safety of CHM in the treatment of OvC after reduction surgery and adjuvant chemotherapy. Method: Chinese National Knowledge Infrastructure (CNKI) and PubMed up to Dec 31st 2018 were searched to identify relevant studies. Only randomized controlled trials (RCTs) were included, and there was no limitation on language of the publication. Data were extracted from all included studies and meta-analysis was performed with Review Manager 5.3. Study quality was assessed and pooled risk ratios (RR) or mean difference (MD) with 95% CIs were used to evaluate the efficacy and safety of CHM. Results: A total of 18 RCTs involving 975 participants were included. There was no placebo, no treatment and CHM alone. Compared with Western Medicine (WM) alone, Chinese herbal Medicine combined with WM (CHM-WM) significantly improved TCM syndromes and symptoms, KPS scores, CD4 counts, CA125 levels, and 3-years survival rate ( P < 0.05). Incidences of gastrointestinal reactions, marrow depression, urinary system symptoms were significantly lower in CHM-WM group than in WM group ( P < 0.01). There was no significant difference in CD3 counts, CD8 counts, quality of life, liver function, and peripheral neuropathy between the two groups ( P > 0.05). Conclusion: The systematic review indicated that CHM combined with WM is effective and safe as a treatment for OvC patients after reduction surgery and adjuvant chemotherapy. However, more high-quality and large-scale RCTs are needed to confirm the efficacy and safety of CHM intervention.

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Section: Resultsmentioning

confidence: 99%

“…Peripheral neuropathy (such as loss of sensation, muscle weakness and atrophy, loss of tendon reflexes, and vasomotor symptoms) was recorded in 3 trials (9, 15, 16). Meta-analysis showed that there was no significant difference in peripheral neuropathy between two groups (RR = 1.11, 95% CI: 0.81–1.50, P = 0.52, Figure 3E).…”

Section: Resultsmentioning

confidence: 99%