Current Design of Mixed-Ligand Complexes of Magnesium(II): Synthesis, Crystal Structure, Thermal Properties and Biological Activity against Mycolicibacterium Smegmatis and Bacillus Kochii

Abstract

The interaction of Mg2+ with 2-furoic acid (HFur) and oligopyridines, depending on the synthesis conditions, leads to the formation of mixed-ligand complexes [Mg(H2O)4(phen)]·2HFur·phen·H2O (1), [Mg(NO3)2(phen)2] (2) and [Mg3(Fur)6(bpy)2]·3CH3CN (3); these structures were determined with an SC X-ray analysis. According to the X-ray diffraction data, in complex 1, obtained in ambient conditions, the magnesium cation coordinated four water molecules and one phenanthroline fragment, while in complexes 2 and 3 (synthesized in an inert atmosphere), the ligand environment of the complexing agent was represented by neutral oligopyridine molecules and acid anions. The thermal behavior of 1 and 2 was studied using a simultaneous thermal analysis (STA). The in vitro biological activity of complexes 1–3 was studied in relation to the non-pathogenic Mycolicibacterium smegmatis and the virulent strain Mycobacterium tuberculosis H37Rv.

Synthesis, Structure, Biological Activity, and Luminescence Properties of a “Butterfly”-Type Silver Cluster with 3-Benzyl-4-phenyl-1,2,4-triazol-5-thiol

“…); dithiocarbamates [ 15 , 16 ]; and redox-active ligands [ 17 , 18 , 19 , 20 , 21 ]. In most cases, after coordination of a biologically active molecule to a metal ion, the bioactivity of the resulting complex increases significantly [ 22 , 23 , 24 , 25 , 26 ], simultaneously reducing the toxicity and, therefore, the lethal dose of an organic ligand, which make it possible to use this substance in therapy.…”

“…Also, the purpose of this study was to find out whether the free ligand and its silver complex exhibit biological activity against M. Smegmatis (a model non-virulent strain of M. tubercolisis ) and how the coordination of the ligand affects these properties. This current work is a part of our ongoing research to find new anti-tuberculosis metallodrugs [ 22 , 24 , 25 , 26 , 62 ].…”