Current Daily Glucocorticoid Use and Serum Creatinine Levels Are Associated With Lower 25(OH) Vitamin D Levels in Thai Patients With Systemic Lupus Erythematosus

Chaiamnuay, Sumapa; Chailurkit, La‐or; Narongroeknawin, Pongthorn; Asavatanabodee, Paijit; Laohajaroensombat, Sukij; Chaiamnuay, P

doi:10.1097/rhu.0b013e318289bd16

Cited by 36 publications

(39 citation statements)

References 34 publications

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“…It is possible that NMOSD patients with higher levels of disability showed lower 25(OH)D 3 levels because lifestyle changes led to less outdoor activity and inadequate sun exposure after the disease onset. In addition, daily oral glucocorticoid use during the disease course may be associated with lower 25(OH) vitamin D levels, as observed in SLE patients [28]. However, our results demonstrated that vitamin D levels were higher in patients with longer disease duration.…”

Section: Discussionsupporting

confidence: 44%

Low Levels of Vitamin D in Neuromyelitis Optica Spectrum Disorder: Association with Disease Disability

et al. 2014

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Patients with autoimmune disorders often have low levels of 25-hydroxyvitamin D [25(OH)D3], which correlates with disability or disease activity. Vitamin D may play a role in neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD), as an important factor involved in immunological pathways. We investigated the relationship between vitamin D levels and disease related disability and clinical activity in patients with NMOSD. Blood samples from 51 patients with NMOSD who were positive for anti-aquaporin4-antibody (AQP4-ab) and 204 healthy controls were collected for 25(OH)D3 measurement. Clinical parameters, including expanded disability status scale (EDSS) score, annualized relapse rate (ARR) and time of blood sampling relative to attack, were determined in patients with NMOSD. We found that 25(OH)D3 levels were significantly lower in patients with NMOSD compared to healthy controls. There was no difference between 25(OH)D3 levels in blood samples taken at relapse or remission, and no association between 25(OH)D3 levels and ARR, but there was an inverse correlation between 25(OH)D3 levels and EDSS scores in patients with NMOSD. It remains to be determined whether low vitamin D levels predispose to NMO and/or modify disease severity, or are secondary to neurological disability. In either case the results could also be of relevance to other neurological diseases such as multiple sclerosis as well as NMO.

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Section: Discussionsupporting

confidence: 44%

Low Levels of Vitamin D in Neuromyelitis Optica Spectrum Disorder: Association with Disease Disability

et al. 2014

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“…GC and CsA treatments may lead to fluctuations in the vitamin D level in SLE patients. GC exposure has been reported to be associated with high [12], equivocal [13], or low [14,36] vitamin D levels. An animal study revealed that CsA treatment is associated with vitamin D resistance through downregulation of vitamin D receptors in spite of an increase in 1,25(OH) 2 D 3 level [37].…”

Section: Fgf-23 Bone Metabolism and Fgf-23 Determinantsmentioning

confidence: 99%

“…Elevated FGF-23 is associated with increased overall osteoporotic fracture risk in elderly men [11]. The relationships among GC treatment, BMD, PTH, and vitamin D level in SLE patients have been elucidated in recent years [12][13][14][15]. However, the effects of GC and CsA treatment on bone metabolic profiles, especially the FGF-23 level, and their relationships to BMD in SLE patients have not been investigated, and the role of FGF-23 and other markers of bone metabolism in drug-induced osteoporosis are less described.…”

Section: Introductionmentioning

confidence: 99%

Increased serum fibroblast growth factor-23 and decreased bone turnover in patients with systemic lupus erythematosus under treatment with cyclosporine and steroid but not steroid only

et al. 2014

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“…1 2 Studies within patients with SLE indicate that lower 25[OH]D levels may correlate with increased disease activity, [3][4][5][6][7][8][9][10][11][12][13][14][15][16] although inconsistently. [17][18][19][20][21][22][23][24] Variation within the vitamin D receptor gene (VDR), the vitamin D receptor protein that binds the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25[OH] 2 D), has been associated with higher SLE disease activity in females 25 and higher damage score. 26 Whether vitamin D is related to risk of developing SLE has not been clearly established.…”

Section: Introductionmentioning

confidence: 99%

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

et al. 2016

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Objective We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE. Methods 436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (± 3.9) years later. Fifty-six individuals transitioned to SLE (≥4 cumulative ACR criteria). 25-hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single nucleotide polymorphisms (SNPs) in four vitamin D genes were genotyped. Generalized estimating equations, adjusting for correlation within families, were used to test associations between the vitamin D variables and the outcome of transitioning to SLE. Results Mean baseline 25[OH]D levels (p=0.42) and vitamin D supplementation (p=0.65) were not different between those who did and did not transition to SLE. Vitamin D deficiency (25[OH]D <20 ng/ml) was greater in those who transitioned compared to those who did not transition to SLE (46% versus 33%, p=0.05). The association between 25[OH]D and SLE was modified by CYP24A1 rs4809959, where for each additional minor allele, increased 25[OH]D was associated with decreased SLE risk: 0 minor alleles (adjusted OR:1.03, CI:0.98,1.09), 1 minor allele (adjusted OR:1.01, CI:0.97,1.05), 2 minor alleles (adjusted OR:0.91, CI:0.84,0.98). Similarly, vitamin D deficiency significantly increased the risk of transitioning to SLE in those with two minor alleles at rs4809959 (adjusted OR:4.90, CI: 1.33,18.04). Conclusions Vitamin D status and CYP24A1 may have a combined role in the transition to SLE in individuals at increased genetic risk for SLE.

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Current Daily Glucocorticoid Use and Serum Creatinine Levels Are Associated With Lower 25(OH) Vitamin D Levels in Thai Patients With Systemic Lupus Erythematosus

Cited by 36 publications

References 34 publications

Low Levels of Vitamin D in Neuromyelitis Optica Spectrum Disorder: Association with Disease Disability

Low Levels of Vitamin D in Neuromyelitis Optica Spectrum Disorder: Association with Disease Disability

Increased serum fibroblast growth factor-23 and decreased bone turnover in patients with systemic lupus erythematosus under treatment with cyclosporine and steroid but not steroid only

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

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