Current controversies regarding the role of asbestos exposure in the causation of malignant mesothelioma: the need for an evidence-based approach to develop medicolegal guidelines

Marchevsky, Alberto M.; Wick, Mark R.

doi:10.1016/s1092-9134(03)00078-9

Cited by 31 publications

(12 citation statements)

References 149 publications

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“…Conversely, only erionite fibers promote HMC transformation, possibly because these fibers are less cytotoxic than amosite, having a lower content of iron 7. Chrysotile fibers, in spite of their reduced cytotoxicity, are unable to cause cell proliferation, as previously reported 40. Even short term exposure for 24 hr to erionite fibers induced low cytotoxicity, allowing a high proliferation rate, associated with formation of DNA adducts.…”

Section: Discussionsupporting

confidence: 57%

Erionite and asbestos differently cause transformation of human mesothelial cells

Bertino

Marconi²,

Palumbo³

et al. 2007

Intl Journal of Cancer

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Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperation between asbestos and other cofactors, such as SV40 virus infection. Nevertheless, several cases of MM were associated with environmental exposure to erionite in Turkey, where SV40 was never isolated in MM specimens. We show here that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells (HMC). Long term exposure to erionite, but not to asbestos fibers, transforms HMC in vitro, regardless of the presence of SV40 sequences, leading to foci formation in cultured monolayers. Cells derived from foci display constitutive activation of Akt, NF-jB and Erk1/2, show prolonged survival and a deregulated cell cycle, involving cyclin D1 and E overexpression. Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation. ' 2007 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 57%

Erionite and asbestos differently cause transformation of human mesothelial cells

Bertino

Marconi²,

Palumbo³

et al. 2007

Intl Journal of Cancer

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“…In the past, the approach to mesothelioma diagnosis has not always been consistent with the principles of evidenced-based medicine. 122,123 Many studies have been based on ''circular reasoning'' whereby biased assumptions were applied regarding results of immunostains based on the selection of cases that were declared by the investigators to represent ''classic examples'' of mesothelioma, without providing in their study an in-depth scrutiny of clinical, radiographic, or other parameters to support the diagnosis (such as demonstration of mesothelial features by electron microscopy, appropriately short, dismal survival, evidence of no tumor elsewhere on follow-up or at autopsy, etc). In short, not all studies have followed stringent criteria for inclusion of cases, or used appropriately matched controls, or have been based on reproducible parameters that could reduce bias in the interpretation of the findings.…”

Section: Discussionmentioning

confidence: 99%

Applications and Limitations of Immunohistochemistry in the Diagnosis of Malignant Mesothelioma

Suster

Moran

2006

Advances in Anatomic Pathology

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Malignant mesothelioma is an uncommon malignant epithelial neoplasm originating from the serosal surface of body cavities. Because serosal surfaces are a common site of metastatic spread for a variety of malignant neoplasms originating from internal organs, separating malignant mesothelioma from metastatic tumors is of clinical importance. The diagnosis of malignant mesothelioma is complex and usually requires a multimodal approach that includes careful clinical history and physical examination, imaging studies, and tissue sampling for multimodal evaluation including routine histology, histochemistry, electron microscopy, and immunohistochemical tests. Of these, immunohistochemistry has emerged as the most valuable and readily available modality for the routine evaluation of these tumors. Unfortunately, no specific antibodies have yet been developed that can be accepted as exclusive for these tumors. The immunohistochemical diagnosis of malignant mesothelioma therefore depends on the use of a panel of stains that includes markers that are commonly expected to react with these tumors ("positive" markers) and markers that are not commonly expected to react with these tumors ("negative" markers). Additionally, the selection and utility of these various markers can vary considerably based on a constellation of circumstances, including patient sex, histologic appearance of the tumor (ie, epithelioid vs. sarcomatoid, etc), and various other clinical circumstances. Herein, we will review the currently available immunohistochemical markers used for the diagnosis of malignant mesothelioma and offer suggestions for the use of appropriate panels of stains based on specific morphologic types and clinical circumstances.

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“…In our 6 cases, other 2 asbestos and tremolite contaminated in chrysotile as shown in Table 5. Tremolite has been described to have a carcinogenic potential to cause malignant mesothelioma 21) . The problem which chrysotile or conterminated tremolite causes malignant mesothelioma has partially been controversial.…”

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

et al. 2004

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Malignant pleural mesothelioma is induced by asbestos exposure. Many reports have described this situation in America and European countries, but a few have been published in Japan. In this study malignant pleural mesothelioma cases in hospitals located in an area facing the Seto Inland Sea were evaluated. A total of 106 patients were examined with 100 patients having had occupational exposure to asbestos and 6 patients without such histories of asbestos exposure. Ninety seven were male and 9 were female. Ages ranged from 41 to 87 yr with mean of 64.8 ± 5.3 yr. Thirty seven cases showed epithelial type of tumor, 25 biphasic type and 15 showed sarcomatous. The remaining 23 cases had insufficient evidence for typing the tumor. The mean survival rate for all cases was 9.2 ± 11.6 months. Fifty-one patients had occupational histories of shipyard work, 16 patients worked in asbestos cement piping, and the remainder were employed in miscellaneous jobs related asbestos exposure. The duration of asbestos exposure ranged up to 20 yr or longer with the mean of 17.2 ± 8.9 yr and the average latent period for the occurrence of malignant pleural mesothelioma was more than 31 yr with the mean of 37.0 ± 13.3 yr. Quantification of asbestos bodies in the lungs indicated a high concentration in most patients and the major types of asbestos fibers were crocidolite and amosite. Six cases appeared after exposure to chrysotile. These results indicated that ninety four percent of malignant pleural mesothelioma appeared due to the exposure to asbestos including crocidolite and amosite. The remainder may be blamed on exposure to chrysotile.

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Current controversies regarding the role of asbestos exposure in the causation of malignant mesothelioma: the need for an evidence-based approach to develop medicolegal guidelines

Cited by 31 publications

References 149 publications

Erionite and asbestos differently cause transformation of human mesothelial cells

Erionite and asbestos differently cause transformation of human mesothelial cells

Applications and Limitations of Immunohistochemistry in the Diagnosis of Malignant Mesothelioma

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

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