Current Concepts of the Biology of Human Cutaneous Malignant Melanoma

Wh, Clark; Mj, Mastrangelo; Am, Ainsworth; Berd, David; Re, Bellet; Ea, Bernardino

doi:10.1016/s0065-230x(08)61017-9

Cited by 70 publications

(34 citation statements)

References 151 publications

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“…The incidence of familial melanoma has been reported to be from 1 to 6% of all melanoma patients (Clark et al, 1977;Anderson, 1971). However, only 18 such patients were available for the present study in this unit, and it is apparent that caution is needed in assessing the significance of studies on such small numbers of patients.…”

Section: Discussionmentioning

confidence: 95%

Low natural-killer-cell activity in familial melanoma patients and their relatives

Hersey¹,

Edwards²,

Honeyman³

et al. 1979

Br J Cancer

133

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Summary.-Patients with melanoma who had one or more close relatives with melanoma were studied for their natural-killer-cell (NK) activity against cultured melanoma cells and Chang cells. A high proportion of the patients and their relatives were found to have low NK activity against these target cells. In most of the patients this could not be attributed to general depression of their immune function, since Band T-cell numbers and the mitogenic response to PHA were within normal limits. The levels of NK activity of the patients and their relatives were found to be significantly correlated, suggesting that the NK activity in these families may have been genetically (or environmentally) determined. Several genetic markers were examined in the patients and their relatives for association with the disease state and NK activity. No association with HLA antigens or ABO blood groups was detected, but there was a low incidence of the Rhesus negative phenotype in the patients (the Rh phenotype had previously been associated with high NK activity).The present results indicate that NK activity has a familial association in families with a high incidence of melanoma, and raise the question whether low NK activity may be one of the predisposing factors in the development of familial melanoma.

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Section: Discussionmentioning

confidence: 95%

Low natural-killer-cell activity in familial melanoma patients and their relatives

Hersey¹,

Edwards²,

Honeyman³

et al. 1979

Br J Cancer

133

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“…The criteria used to assign histopathological type were those given by McGovern et al (1973) and Clark et al ( , 1975Clark et al ( , 1977. Acral-lentiginous melanoma (ALM) is now recognised as a distinct entity, and was used in this study as defined by Arrington et al (1977).…”

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confidence: 99%

The incidence and pathogenesis of invasive cutaneous malignant melanoma in Northern Ireland

Gordon¹,

Lowry²

1986

Br J Cancer

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Summary Three hundred and four suspected cases of malignant melanoma diagnosed in Northern Ireland over a 5 year period have been reviewed. Two hundred and forty fulfilled the diagnostic criteria of invasive cutaneous malignant melanoma (CMM) and were accepted as suitable for analysis an incidence of 3.12. The female to male ratio for CMM in this study is 3:1. This excess of female lesions occurs at all major anatomical sites and for all tumour types. There are many thick melanomas in the province, and 67% of cases were greater than 1.7mm thick. Each tumour type has a distinctive age curve. The implications of these findings are discussed. The evidence suggests that intrinsic factors are as important as extrinsic factors.Malignant melanoma is a potentially lethal form of skin cancer. Its incidence and mortality is increasing in most countries studied. The disease is found in a younger age group than most other forms of cancer. Different forms of melanoma may have different patterns of incidence, growth and prognosis.Apart from Scotland (MacKie & Hunter, 1982) it has been unusual to use the population of an entire country as the basis for a study of melanoma and correlate histopathological parameters with age, sex and site. Northern Ireland is a relatively closed geographical entity with sufficient numbers of cases for analysis. Moreover its limited size allows accessibility to virtually all patients. A detailed' histopathological examination of all cases of melanoma referred to the three pathology centres over a 5-year period was therefore undertaken.The population of Northern Ireland was 1,538,800 at the time of this study. It is situated between 54°N and 56°N latitude. There is a maritime climate and the annual solar radiation incident on a horizontal surface is 1,000kWh per square meter (Cruikshank & Wilcock, 1982 cases were accepted for the study. There are only three pathology centres in Northern Ireland and all biopsy specimens are submitted to these centres. Through the kind co-operation of the consultant pathologists, the histopathological records of the three centres were completely reviewed for the 5-year period between 1974-1978. The only possible cases of melanoma that might not be included in this survey would presumably be those cases not submitted for biopsy. At a joint melanoma group meeting with general surgeons, plastic surgeons, pathologists, dermatologists and other clinicians in the province, it was considered that very few cases of melanoma would escape histopathological confirmation in Northern Ireland.Eye lesions, metastases from primaries diagnosed previously, and second excisions were all excluded. Cases of multiple primary melanoma were only considered if the first primary occurred during the period of study.Three hundred and four cases were thus available for study. Of these, 15 cases of lymph node melanoma had no identifiable primary site and were excluded because no cutaneous melanoma has been found. The remaining 289 cases were histopathologically examined. Eight cases of anal, vag...

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“…It is noteworthy that in ongoing studies on samples from patients with uveal melanoma, a similar difference between blood and BM is seen, whereas in lung cancer and osteosarcoma patients, the discrepancy between the fraction of positives in blood and BM was much less pronounced. 1 It might be argued that the rosetted cells might also include rare BM cells or even cutaneous cells contaminating the sample. Several additional lines of evidence argue against this possibility.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant melanoma accounts for 1-3% of all malignancies (1) and has, in the last decade, been the most rapidly increasing type of cancer. The metastatic capacity of a melanoma is closely related to the vertical growth phase (2), and melanomas with a thickness of Ͻ0.75 mm have a remarkable cure rate of about 95% (3).…”

Section: Introductionmentioning

confidence: 99%

Immunomagnetic Detection and Clinical Significance of Micrometastatic Tumor Cells in Malignant Melanoma Patients

Faye

Aamdal

Høifødt³

et al. 2004

Clinical Cancer Research

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Current Concepts of the Biology of Human Cutaneous Malignant Melanoma

Cited by 70 publications

References 151 publications

Low natural-killer-cell activity in familial melanoma patients and their relatives

Low natural-killer-cell activity in familial melanoma patients and their relatives

The incidence and pathogenesis of invasive cutaneous malignant melanoma in Northern Ireland

Immunomagnetic Detection and Clinical Significance of Micrometastatic Tumor Cells in Malignant Melanoma Patients

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