Current concepts of IgE regulation and impact of genetic determinants

Different FCER1A polymorphisms influence IgE levels in asthmatics and non‐asthmatics

“…We found different patterns of association between asthmatics and non‐asthmatics, and we explored the effects of FCER1A variants on atopy and ‘allergic disorders’, such as asthma, atopic dermatitis, or allergic rhinitis. Our observation of the association between FCER1A SNPs and total serum IgE levels confirms and extends the previous findings of GWA‐based and candidate gene studies .…”

Lack of Association between theIL-13 C-1112T, G2044APolymorphisms and Graves’ Disease Risk: Evidence from a Meta-analysis

“…It promotes IgE class switching, up-regulates the expression of major histocompatibility complex (MHC) class II molecules and inhibits inflammatory cytokine production, such as IL-1a, IL-1b, IL-8 and tumor necrosis factor (TNF)-a (Wynn, 2003). Numerous single nucleotide polymorphisms (SNPs) have been identified in human IL-13 gene and have been reported to be associated with IgE levels and allergic diseases (Granada et al, 2012;Pantelidis et al, 2000;Potaczek & Kabesch, 2012;Vercelli, 2002). Thus, IL-13 is considered to be a candidate gene for GD.…”

Current status of therapy with omalizumab in children

“…Other cells involved in this inflammatory mechanism, such as dendritic cells, monocytes, smooth muscle cells, and eosinophils, are also activated through their high-affinity receptors to IgE [1,2]. Specific IgE attached to the high-affinity receptors on mast cells and basophils binds allergens and triggers an inflammatory response through the release of chemical mediators like histamine, tryptase, and arachidonic acid metabolites.…”