Current concepts of hypoxic-ischemic cerebral injury in the term newborn

Hill, Alan

doi:10.1016/0887-8994(91)90060-x

Cited by 162 publications

(72 citation statements)

References 73 publications

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“…PVL is the most frequent pattern of injury in these patients and can be associated with GMH, intraventricular hemorrhage, and periventricular hemorrhagic infarction. 1,2 On the other hand, in full-term neonates, cortical and deep gray matter is mostly affected 3 ; however, recent studies 4,5 have also reported isolated WM lesions in 20% of term neonates with hypoxicischemic insult.…”

mentioning

confidence: 99%

Deep Medullary Vein Involvement in Neonates with Brain Damage: An MR Imaging Study

Arrigoni

Parazzini

Righini

et al. 2011

AJNR Am J Neuroradiol

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mentioning

confidence: 99%

Deep Medullary Vein Involvement in Neonates with Brain Damage: An MR Imaging Study

Arrigoni

Parazzini

Righini

et al. 2011

AJNR Am J Neuroradiol

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“…According to Perlman observation and others working on the same problem, even such mild ischemia can be harmful to preterm brain. 10,11,16,18 In this study, we found that the PVL prevalence for infant less than 32 week-gestation was We did not expect to find hyperdense lesion such as mentioned by Volpe 9 because ultrasound scan was performed after the age of first week. Protocol to screen premature infant had not been developed in our hospital and infant must be transported to the radiology unit to have an ultrasound scan.…”

Section: Discussionmentioning

confidence: 84%

Periventricular leucomalacia in premature infants in neonatal ward, Cipto Mangunkusumo Hospital: A preliminary study

Firman¹,

Amir²,

Kurniati³

et al. 2016

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Introduction Periventricular leucomalacia (PVL) is a major causeof neurodevelopment delay in premature infants, so early detec-tion of the preterm infant at high risk for the subsequent develop-ment of this lesion is critical.Objectives To determine the prevalence of PVL in premature in-fants hospitalized in neonatal ward, Cipto Mangunkusumo Hospi-tal using cranial ultrasound scans and define its characteristicsMethods Premature infants hospitalized in the neonatal ward fromJanuary to July 2003 were included in this study. Clinical featureswere retrieved from medical charts. Ultrasound scan was performedonce, after the age of 7 days and interpretations were read sepa-rately by two consultants of the radiology division.Results Fifty-one infants were included, 21 with <32-week gesta-tion, 30 with >32-week gestation; birth weight range were 1000 to2600 gram. Nineteen infants had cystic lesion and/or dilatation ofthe ventricle from the cranial ultrasound scan. The prevalence ofPVL in gestational age (GA) of <32 weeks was 6/21 and that in GAof >32 weeks was 13/30. Risk factors found in infants with PVLwere maternal infection, respiratory distress, sepsis and circula-tory failure.Conclusion The prevalence of PVL in preterm infants in CiptoMangunkusumo neonatal ward was higher than that was reportedin developed countries. Maternal infection, respiratory distress,sepsis, and circulatory failure which were commonly found in theseinfants were factors to be considered as risks for PVL

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“…TUNEL-positive cells were observed much more frequently in rats with IUGR. Neuronal apoptosis has been suggested to be related to dysfunction (30,31) . If a series of behavioural tests were performed during adolescence, mental deficiencies would be found.…”

Section: Discussionmentioning

confidence: 99%

A Model of Intrauterine Growth Restriction Was Induced by Bilateral Uterine Vessel Clamping in Pregnant Rats

Diao¹,

Li²,

Qu³

et al. 2017

J Anesth Perioper Med

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Background: Intrauterine growth restriction (IUGR) is considered to be a major risk for cerebral palsy and disability after birth. However, IUGR lacks effective treatment strategies. We aimed to establish a rat model of bilateral uterine artery ischemia-reperfusion as a surgical model of IUGR. Methods: At the 17th day of pregnancy, six Sprague-Dawley (SD) rats were randomly divided into sham (NOR) and growth restriction (GR) groups. In the GR groups, four small artery clamps were used to occlude the uterine vessels near the lower and upper ends of the bilateral horns for 25 min; then, the clamps were removed, and the horns were placed back into the abdomen cavity. In the sham-operated animals, the uterine horns were exposed for 25 min without artery clamping. After labour and delivery, the death rates and weights during the first 8 days of newborn rats were recorded. A pathological examination was performed with hematoxylin-eosin staining (HE) staining and terminal deoxynucleotidyl transferase-mediated dUTP nick endlabeling staining (TUNEL) on 4-day-old and 8-day-old brain tissues of the newborn rats. Results: The mortality within the first 24 h of rats in the GR group were increased (66.7% vs 0.0% ), and their daily weights within the first 8 postnatal days were decreased. In addition, the karyopyknosis percentages of 4-day-old and 8-day-old rats were increased (4-day-old: 45% vs 11%; 8-day-old: 34.7% vs 5.3%), and the numbers of TUNEL-positive cells were increased (4-day-old: 110 vs 12.7; 8-day-old: 146.7 vs 4). Conclusions: This model of foetal IUGR produced a decrease in weight, an increase in the death rate within 24 h and an increase in apoptosis in newborn rats. The establishment of the model was successful.

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Current concepts of hypoxic-ischemic cerebral injury in the term newborn

Cited by 162 publications

References 73 publications

Deep Medullary Vein Involvement in Neonates with Brain Damage: An MR Imaging Study

Deep Medullary Vein Involvement in Neonates with Brain Damage: An MR Imaging Study

Periventricular leucomalacia in premature infants in neonatal ward, Cipto Mangunkusumo Hospital: A preliminary study

A Model of Intrauterine Growth Restriction Was Induced by Bilateral Uterine Vessel Clamping in Pregnant Rats

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