Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system

Voltaggio, Lysandra; Cimino‐Mathews, Ashley; Bishop, Justin A.; Argani, Pedram; Cuda, Jonathan D.; Epstein, Jonathan I.; Hruban, Ralph H.; Netto, George J.; Stoler, Mark H.; Taube, Janis M.; Vang, Russell; Westra, William H.; Montgomery, Elizabeth A.

doi:10.3322/caac.21350

Cited by 38 publications

(36 citation statements)

References 136 publications

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“…As an invasive early examination, endoscopy screening for esophageal cancer was generally considered controversial, but that depends on factors discussed below. For EAC and Barrett's esophagus, evidence from population‐based cohort studies have supported the decrease of mortality and better survival by endoscopy screening .…”

Section: Discussionmentioning

confidence: 99%

Endoscopy screening effect on stage distributions of esophageal cancer: A cluster randomized cohort study in China

Guan

Song

et al. 2018

Cancer Science

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Efficacy of endoscopic screening for esophageal cancer is not sufficiently definitive and lacks randomized controlled trial evidence. The present study proved short‐term screening efficacy through describing and comparing disease stage distributions of intervention and control populations. Villages from Linzhou and Cixian were cluster randomly allocated to the intervention or to the control group and the target population of 52 729 and 43 068 individuals was 40‐69 years old, respectively, and the actual enrolled numbers were 18 316 and 21 178, respectively. TNM stage information and study‐defined stage information of esophageal cases from 2012 to 2016 were collected. Stage distributions were compared between the intervention and control groups in the total target population, as well as in the subgroup populations in terms of enrolment and before or after intervention. There were a total of 199 and 141 esophageal cancer cases in the intervention and control groups, respectively. For the target population, distributions of TNM stage were borderline significant between the two groups after intervention (P = .093). However, subgroup analysis of the enrolled population during the after‐intervention period had statistical significance for both TNM and study‐defined stage. Natural TNM stage distributions were approximately 32%, 41%, 24% and 3% for stages I to IV vs 71%, 19%, 7% and 3% in the intervention population. The natural study‐defined stage distributions from early, middle to advanced stages were approximately 18%, 49% and 33% vs 59%, 33% and 8%. Early‐stage esophageal cancer cases accounted for a higher proportion after endoscopy screening, and the efficacy in the target population depends on the intervention compliance.

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Section: Discussionmentioning

confidence: 99%

Endoscopy screening effect on stage distributions of esophageal cancer: A cluster randomized cohort study in China

Guan

Song

et al. 2018

Cancer Science

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“…All cases were diagnosed by the same qualified (more than 20 years of experience) pathologist, according to the two-tiered Bethesda terminology, in use as of January 2010, for histology reports concerning SILs, in accordance with the relevant AFIP fascicle; the superiority of this system over the previous, three-tiered cervical intraepithelial neoplasia (CIN) has been repeatedly proven with a recent report depicting an inter-observer variability (kappa index) of 0.68 versus 0.46 [11,12]. Although performed, immunostaining both for Ki67 and p16 were used only as adjunctive, non-confirmatory parameters, given the controversy concerning interpretation of p16 immunostaining in histological sections [13].…”

Section: Methodsmentioning

confidence: 99%

γH2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL

et al. 2017

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BackgroundγH2AX is a protein biomarker for double-stranded DNA breakage; its expression was studied in cervical squamous intraepithelial lesions and carcinomas.MethodsImmunostaining for phospho-γH2AX was performed in sections from histologically confirmed cervical SIL and carcinomas, as well as from normal cervices used as controls. In total, 275 cases were included in the study: 112 low grade SIL (LGSIL), 99 high grade SIL (HGSIL), 24 squamous cell carcinoma (SCC), 12 adenocarcinoma and 28 cervical specimens with no essential lesions. Correlation of histological grading, high risk vs. low risk HPV virus presence, activated vs. non-activated status (by high risk HPV mRNA expression) and γH2AX expression in both basal and surface segments of the squamous epithelium was performed.ResultsGradual increase of both basal and surface γH2AX expression was noted up from normal cervices to LGSIL harboring a low risk HPV type, to LGSIL harboring a high risk virus at a non-activated state (p<0.05). Thereafter, both basal and surface γH2AX expression dropped in LGSIL harboring a high risk virus at an activated state and in HGSIL.ConclusionsγH2AX could serve as a potential biomarker discriminating between LGSIL and HGSIL, as well as between LGSIL harboring high risk HPV at an activated state.

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“…From 2015 to 2030, the estimated mortality rate of CC will increase by approximately 22% in the whole world [5]. transformation induced by human papillomavirus (HPV) oncogenes, with the potential of progression to the invasive tumor [7]. Therefore, identification of CIN or early CC is extremely significant.…”

Section: Introductionmentioning

confidence: 99%

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis

Jiang

Hu²,

Zuo

et al. 2020

BioMed Research International

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Background. Cervical cancer (CC) is one of the most common female malignant tumors. And cervical intraepithelial neoplasia (CIN) is the precancerous lesion of CC, which can progress to invasive CC. MicroRNAs (miRNAs) have been found to be potential diagnostic biomarkers for CIN or CC. However, recently, the lack of sufficient studies about the diagnostic value of miRNAs for CIN made it challenging to separately investigate the diagnostic efficacy of miRNAs for CIN. Likewise, the conclusions among those studies were discordant. Therefore, we conducted this meta-analysis, aimed at evaluating the diagnostic efficacy of miRNAs for CIN and CC patients. Methods. Literature search was performed in PubMed, Embase, and Web of Science databases. Pooled sensitivity, specificity, and other diagnostic parameters were calculated through Stata 14.0 software. Furthermore, subgroup analyses and metaregression analysis were conducted to explore the main sources of heterogeneity. Results. Ten articles covering 50 studies were eligible, which included 5,908 patients and 4,819 healthy individuals. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.81 (95% CI, 0.77-0.85), 0.86 (95% CI, 0.83-0.89), 5.9 (95% CI, 4.5-7.7), 0.22 (95% CI, 0.17-0.28), 27 (95% CI, 17-44), and 0.91 (95% CI, 0.88-0.93), respectively. Additionally, the ethnicity and internal reference were the main sources of heterogeneity. Conclusions. Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies.

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Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system

Cited by 38 publications

References 136 publications

Endoscopy screening effect on stage distributions of esophageal cancer: A cluster randomized cohort study in China

Endoscopy screening effect on stage distributions of esophageal cancer: A cluster randomized cohort study in China

γH2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis

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