Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation

Prophylaxis Against Pneumocystis jirovecii Pneumonia in Adults

“…Prophylactic dosing of trimethoprim-sulfamethoxazole for patients with normal kidney function is typically 1 double-strength oral tablet (800/160 mg) daily or 3 times per week or 1 single-strength tablet (400/80 mg) daily, and is usually well-tolerated. Exanthem and nausea are common adverse effects . If trimethoprim-sulfamethoxazole is discontinued for a mild adverse effect, reinstitution of medication should be considered after resolution of the adverse reaction.…”

“…Exanthem and nausea are common adverse effects. 2 If trimethoprim-sulfamethoxazole is discontinued for a mild adverse effect, reinstitution of medication should be considered after resolution of the adverse reaction. Those with allergic reactions may require desensitization with allergy consultation.…”

“…PCP can be prevented by reducing immunosuppression and with chemoprophylaxis. Effective prophylaxis significantly decreases the incidence of infection . This article summarizes current recommendations regarding prevention of PCP in patients who are immunocompromised …”

“…Effective prophylaxis significantly decreases the incidence of infection. 2 This article summarizes current recommendations regarding prevention of PCP in patients who are immunocompromised. [3][4][5] Indications for Prophylaxis Primary prophylaxis is intended to prevent a first episode of PCP and should be administered in patients at risk for PCP due to specific medical conditions or treatments (Table ).…”

Early application of awake extracorporeal membrane oxygenation in pneumocystis jirovecii pneumonia complicated with severe acute respiratory distress syndrome: a case report

“…These patients often require immunosuppressive medications to prevent rejection of the transplanted organ or graft-versushost disease, which can weaken their immune system and make them more susceptible to 10.3389/fmed.2023.1264928 Frontiers in Medicine 02 frontiersin.org opportunistic infections such as PJP (1). As a lung infection, PJP may result in respiratory failure, necessitating advanced respiratory support (2). Venovenous extracorporeal membrane oxygenation (VV-ECMO) has traditionally been employed as a salvage therapy to treat patients with respiratory failure under adequate sedation and analgesia (3,4).…”