Current concepts in the development of therapeutics against human and animal coronavirus diseases by targeting NP

Tseng, Yeu Yang; Liao, Guan Ru; Lien, Abigail; Hsu, Wei Li

doi:10.1016/j.csbj.2021.01.032

Cited by 12 publications

(11 citation statements)

References 67 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The S2 subunit locates in the central region that contributes to the fusion of the virus with cell membrane [ 11 , 13 ]. The N protein of SARS-CoV-2 binds to and packages the 30 kb RNA viral genome into a ribonucleoprotein complex (RNP) [ 14 ]. The modular structure and the dynamic nature of the nucleocapsid protein contribute to its rapid dissociation and exposure of the RNA genome quickly after infection.…”

Section: Introductionmentioning

confidence: 99%

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Wang

et al. 2022

J Biomed Sci

View full text Add to dashboard Cite

The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflammatory response associated with dysregulation of innate immunity causes severe acute respiratory syndrome (SARS) and death. In this review, we update the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. We emphasize Type I interferon response and the strategies of evading innate immune defense used by SARS-CoV-2. We also extensively discuss the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. This review would help us to figure out the current challenge questions of SARS-CoV-2 infection on innate immunity and directions for future studies.

show abstract

Section: Introductionmentioning

confidence: 99%

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Wang

et al. 2022

J Biomed Sci

View full text Add to dashboard Cite

show abstract

“…The N proteins of coronaviruses, including PEDV and SARS-CoV-2, share a similar domain structure, consisting of an N-arm, an N-terminal domain (NTD), a Ser/Arg-rich linker (LKR), a C-terminal domain (CTD), and a C-tail [ 33 – 36 ]. NTD and CTD are structured domains, whereas the N-arm, LKR, and C-tail are intrinsically disordered regions (IDRs).…”

Section: Domain Structure and Biological Functions Of The Nucleocapsi...mentioning

confidence: 99%

Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses

2022

View full text Add to dashboard Cite

Coronaviruses can have a devastating impact on the health of humans and animals. Porcine epidemic diarrhea virus (PEDV) causes extremely high fatality rates in neonatal piglets, whereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic in humans. As a critical component of the host antiviral innate immune response, type I interferon production and signaling play a very important role, especially in the initial phase of the antiviral responses. Coronaviruses have evolved multiple ways to counteract type I interferon responses. Although the primary functions of the nucleocapsid protein are to facilitate viral RNA replication and package viral genomic RNA into virions, recent studies have shown that the nucleocapsid protein is also involved in virus-host interactions. The aim of this review is to summarize our current understanding of how the nucleocapsid proteins of PEDV and SARS-CoV-2 modulate type I interferon responses. This knowledge will be useful for developing strategies to combat coronavirus infections.

show abstract

“…Thanks to the unremitting efforts of the vast number of scientists, several vaccines were invented and gradually controlled the spread of the epidemic [ 3 , 4 ]. However, mutations in spike protein of SARS-CoV-2 render it a global healthcare challenge [ 5 ]. As a result, agents against SARS-CoV-2 infection are urgently needed for the clinical treatment of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2

Wang

Long

Ding

et al. 2022

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

Current concepts in the development of therapeutics against human and animal coronavirus diseases by targeting NP

Cited by 12 publications

References 67 publications

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses

Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2

Contact Info

Product

Resources

About