Current concepts in radiation enteritis and implications for future clinical trials

Nguyen, Nam P.; Antoine, John E.; Dutta, Suresh; Karlsson, Ulf; Sallah, Sabah

doi:10.1002/cncr.10766

Cited by 86 publications

(46 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Preliminary studies also suggest that IFN-γ may be effective in the treatment of patients with radiationinduced cutaneous fibrosis. IFN-γ should be considered in Phase Ⅰ-Ⅱ studies to assess its toxicity and efficacy in the treatment of patients with radiation colitis [127] . Many special diets and nutrients, such as the mentioned fiber, elemental diets, SCFAs and amino acids like glutamine, may reduce small-bowel radiation toxicity.…”

Section: Prevention Of Radiation Colitismentioning

confidence: 99%

Recent advances in the management of radiation colitis

Kountouras¹,

Zavos²

2008

WJG

View full text Add to dashboard Cite

show abstract

Section: Prevention Of Radiation Colitismentioning

confidence: 99%

Recent advances in the management of radiation colitis

Kountouras¹,

Zavos²

2008

WJG

View full text Add to dashboard Cite

show abstract

“…Critical structures necessary for normal deglutition, such as tongue, larynx and pharyngeal muscles, may be treated to a high radiation dose. The increased radiation dose may lead to hyperactivation of transforming growth factor b1, a peptide involved in collagen deposition and degradation [6]. Excessive fibrosis may be responsible for abnormal motility of the deglutition muscles and may lead to the aspiration, dysphagia and stenosis observed following head and neck chemoradiation [7].…”

Section: Discussionmentioning

confidence: 99%

Aspiration in Head and Neck Cancer Patients: A Single Centre Experience of Clinical Profile, Bacterial Isolates and Antibiotic Sensitivity Pattern

Lakshmaiah

Sirsath

Subramanyam

et al. 2013

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Most patients with head and neck cancer have dysphagia and are at increased risk of having aspiration and subsequent pneumonia. It can cause prolonged hospitalization, treatment delay and/or interruption and mortality in cancer patients. The treatment of these infections often relies on empirical antibiotics based on local microbiology and antibiotic sensitivity patterns. The aim of present study is to analyse respiratory tract pathogens isolated by sputum culture in head and neck cancer patients undergoing treatment at a tertiary cancer centre in South India who presented with features of aspiration. The study is carried out to establish empirical antibiotic policy for head and neck cancer patients who present with features of aspiration. This was a retrospective study. The study included sputum samples sent for culture and sensitivity from January 2011 to December 2012. Analysis of microbiologic species isolated in sputum specimen and the antibiotic sensitivity pattern of the bacterial isolates was performed. A detailed study of case files of all patients was done to find out which is the most common site prone for producing aspiration. There were 47 (31.54 %) gram positive isolates and 102 (68.45 %) gram negative isolates. The most common bacterial isolates were Klebsiella pneumoniae (25.50 %), Pseudomonas aeruginosa (16.77 %) and Haemophilus influenzae (15.43 %). Levofloxacin was the most effective antibiotic with excellent activity against both gram positive and gram negative isolates. Most patients with aspiration had laryngeal cancer (34.89 %). Aspiration pneumonia was present in 14 (9.39 %) patients. Gram negative bacteria are common etiologic agents in head and neck cancer patients presenting with features of aspiration. Levofloxacin should be started as empirical antibiotic in these patients while awaiting sputum culture sensitivity report. As aspiration in head and neck cancer is an underreported event such institutional antibiotic sensitivity studies should be encouraged for prompt initiation of antibiotic that is most likely to be effective against etiologic pathogens.

show abstract

“…Radiation-induced hydroxyl radicals activating autocrine stimulation of transforming growth factor-beta (TGF-␤ ), a peptide, have been implicated in the fibrosis following surgery or radiation [26,27] . Agents which inhibit TGF-␤ , e.g.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life following Chemoradiation and Postoperative Radiation for Locally Advanced Head and Neck Cancer

Nguyen¹,

Vos²,

Karlsson³

et al. 2007

ORL

Self Cite

View full text Add to dashboard Cite

Background: To evaluate the impact of chemoradiation and postoperative radiation on patients’ quality of life (QOL) in a single institution. Methods: A retrospective analysis of 101 patients who had treatment for locally advanced head and neck cancer in a single institution. Forty-seven patients had chemotherapy and radiation, 54 patients underwent postoperative radiation. QOL was assessed with the University of Washington (UW), and the Hospital Anxiety (HA) and Depression (HD) questionnaires. All patients were free of disease at the survey time. Results: Mean and median UW scores were not different between the 2 groups: chemoradiation (65/67), postoperative radiation (62/63). Mean and median HA scores were 7.6/7 (chemoradiation), and 8.3/8 (postoperative radiation). Mean and median HD scores were 6.7/7 (chemoradiation), and 7.1/7 (postoperative radiation). Forty-four patients developed complications, with mean/median UW, HA, and HD scores of 55/55, 9.9/8, and 8.9/9, respectively. These scores were significantly different compared to the 57 patients without complications: 70/70 (p = 0.0001), 6.5/6 (p = 0.001), and 8.9/9 (p = 0.0001). Conclusion: There was no significant difference in QOL between chemoradiation and postoperative radiation in this retrospective study with a relatively short follow-up in the chemoradiation group. In addition, there were more patients with resectable disease in the postoperative group which may explain the lack of difference in QOL between the two groups. Patients who developed complications following treatment experienced lower QOL, more anxiety and depression. Our study raised the need to conduct a prospective randomized study to assess the real impact of chemoradiation and postoperative radiation on patients’ QOL.

show abstract

Current concepts in radiation enteritis and implications for future clinical trials

Cited by 86 publications

References 103 publications

Recent advances in the management of radiation colitis

Recent advances in the management of radiation colitis

Aspiration in Head and Neck Cancer Patients: A Single Centre Experience of Clinical Profile, Bacterial Isolates and Antibiotic Sensitivity Pattern

Quality of Life following Chemoradiation and Postoperative Radiation for Locally Advanced Head and Neck Cancer

Contact Info

Product

Resources

About