Current Concepts in Prophylactic Antibiotics in Oral and Maxillofacial Surgery

Dammling, Chad; Abramowicz, Shelly; Kinard, Brian

doi:10.1016/j.coms.2021.08.015

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…In addition, comorbidities such as diabetes and medications can affect the disease severity and response to treatment [87]. Besides special considerations such as preventing infective endocarditis, antibiotic prophylaxis should be limited to established guidelines to avoid the risk of antibiotic resistance, toxicity, and excess costs [88]. Meanwhile, based on currently available evidence, prophylactic antibiotics are recommended for surgical extraction of third molars, comminuted mandibular fractures, temporomandibular joint replacements, complex implants involving transplants or multiple implants, and cleancontaminated tumor resections [89].…”

Section: Antibioticsmentioning

confidence: 99%

Medication considerations including safety and its principles in geriatric dentistry

Chu¹

2022

J Adv Pharm Educ Res

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Section: Antibioticsmentioning

confidence: 99%

Medication considerations including safety and its principles in geriatric dentistry

Chu¹

2022

J Adv Pharm Educ Res

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“…Although, eradicating all the germs is impossible and would be also a blast because it could lead to opportunistic infections in the long term. Using a strong disinfection procedure before surgical or other invasive treatments are necessary but carrying it out frequently might be dangerous [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2

Bencze

Temesfői

Das

et al. 2023

BMC Complement Med Ther

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Background Parallel to the growth of the oral healthcare market, there is a constantly increasing demand for natural products as well. Many customers prefer products that contain fewer toxic agents, therefore providing an environmentally friendly solution with the benefit of smaller risk to the user. Medieval and early modern medicinal knowledge might be useful when looking for natural, herbal-based components to develop modern products. Along with these considerations we created, tested, and compared an entirely natural mouthwash, named Herba Dei. Methods The manufacturing procedure was standardized, and the created tincture was evaluated by GC/MS analysis for active compounds, experimentally tested in cell-based cytotoxicity, salivary protein integrity, cell-free antioxidant activity, anti-bacterial and anti-viral assays, and compared with three market-leading mouthwashes. Results Our tincture did not show significant damage in the cytotoxicity assays to keratinocyte and Vero E6 cells and did not disrupt the low molecular weight salivary proteins. Its radical scavenging capacity surpassed that of two tested, partly natural, and synthetic mouthwashes, while its antibacterial activity was comparable to the tested products, or higher in the bacterial aerobic respiratory assay. The active compounds responsible for the effects include naturally occurring phenylpropanoids, terpenes, and terpenoids. Our mouthwash proved to be effective in vitro in lowering the copy number of SARS-CoV-2 in circumstances mimicking the salivary environment. Conclusions The developed product might be a useful tool to impede the transmission and spread of SARS-CoV-2 in interpersonal contact and aerosol-generating conditions. Our mouthwash can help reduce the oral bacterial flora and has an antioxidant activity that facilitates wound healing and prevents adverse effects of smoke in the oral cavity.

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