2012
DOI: 10.1136/gutjnl-2012-303588
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Current concepts and novel targets in advanced pancreatic cancer

Abstract: Pancreatic cancer remains one of the most aggressive tumours with a 5-year survival rate of less than 5%. The dismal prognosis of this tumour entity that is associated with a high degree of drug resistance has not changed over the past decades. Since 1997, gemcitabine-based regimens have been the therapy of choice for advanced pancreatic cancer. Recently, however, new combination chemotherapy regimens achieved a significant survival benefit compared to gemcitabine-based therapies. In addition, novel approaches… Show more

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Cited by 135 publications
(108 citation statements)
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References 86 publications
(98 reference statements)
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“…In vivo experiments. To analyze the metastatic ability of MS cells in vivo, SUIT-2 cells (1x10 6 ) and MS cells (1x10 6 ) suspended in 100 ml DMeM were orthotopically transplanted into the 4-week-old female bALb/c nu/nu mice. At 5-7 weeks after implantation, we sacrificed the mice and all orthotopic tumors and livers were investigated.…”
Section: Immunohistochemical Procedures and Evaluation Of Sectionsmentioning
confidence: 99%
See 1 more Smart Citation
“…In vivo experiments. To analyze the metastatic ability of MS cells in vivo, SUIT-2 cells (1x10 6 ) and MS cells (1x10 6 ) suspended in 100 ml DMeM were orthotopically transplanted into the 4-week-old female bALb/c nu/nu mice. At 5-7 weeks after implantation, we sacrificed the mice and all orthotopic tumors and livers were investigated.…”
Section: Immunohistochemical Procedures and Evaluation Of Sectionsmentioning
confidence: 99%
“…Although efforts to reduce risk factors such as smoking, obesity, and high meat consumption and to improve early detection have been made, pancreatic cancer is still formidable because of its aggressive metastatic ability (3)(4)(5)(6). Pancreatic cancer mainly metastasizes to the lymph nodes, liver, lung, peritoneum and bone.…”
Section: Introductionmentioning
confidence: 99%
“…While early detection of pancreatic cancer is critical to improve patient outcomes [4], there is an urgent need to develop more effective chemotherapies [5]. In 1997 gemcitabine (GEM), a nucleoside analog, replaced fluorouracil (5-FU) as the standard of care for patients with metastatic pancreatic cancer and continues to be the chemotherapeutic of choice to date [5] [6]. Since that time, different chemotherapeutic combination strategies have been used clinically with marginal effects on survivability [5].…”
Section: Introductionmentioning
confidence: 99%
“…A study of patients from [2002][2003][2004][2005][2006][2007][2008], shows that as many as 90% of the pancreatic cancers that could be staged had either regional or distant metastases at the time of diagnosis [2]. While early detection of pancreatic cancer is critical to improve patient outcomes [4], there is an urgent need to develop more effective chemotherapies [5]. In 1997 gemcitabine (GEM), a nucleoside analog, replaced fluorouracil (5-FU) as the standard of care for patients with metastatic pancreatic cancer and continues to be the chemotherapeutic of choice to date [5] [6].…”
Section: Introductionmentioning
confidence: 99%
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