Current concepts and novel applications of LH activity in ovarian stimulation

Low-dose human chorionic gonadotropin may improve in vitro fertilization cycle outcomes in patients with low luteinizing hormone levels after gonadotropin-releasing hormone antagonist administration

“…In several studies, Filicori et al (59)(60)(61) have shown that addition of LH/hCG to ovarian stimulation results in a regression of small ovarian follicles without affecting the number of intermediate (10-14 mm) or large (>14 mm) follicles. These data are confirmed in several randomized controlled trials showing that the addition of either…”

Role of gonadotropin-releasing hormone antagonists in poor responders

“…In response to FSH, granulosa cells express LH receptors in the late follicular phase. Although LH is not required for follicle growth, there is evidence that LH has important effects on follicle dynamics in the late follicular phase (53)(54)(55)(56)(57)(58). Based on these data, one might hypothesize that LH supplementation could improve outcomes in GnRH antagonist cycles.…”

LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility

“…They act by binding to the extracellular domain of their specific receptors, which belong to the superfamily of G protein-coupled receptors [14,15]. Furthermore, FSH and LH are responsible for an adequate folliculogenesis, steroidogenesis in the ovary, oocyte maturation, ovulation, and luteinization [16][17][18][19]. During luteal phase, LH is responsible for maintaining an adequate progesterone secretion; consequently its adequate function is essential during this period.…”