Current Concepts and Methods in Tissue Interface Scaffold Fabrication

Vesvoranan, Oraya; Anup, Amritha; Hixon, Katherine R.

doi:10.3390/biomimetics7040151

Cited by 13 publications

(7 citation statements)

References 353 publications

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“…Tensile strength was measured at 1.19 MPa and compression strength was determined to be 4.2 MPa. The bulk material exhibited a relatively soft network, making it well-suited for the fabrication of soft TE scaffolds [ 69 , 70 , 71 ].…”

Section: Resultsmentioning

confidence: 99%

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Kainz,

Perak,

Stubauer

et al. 2024

Polymers

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Additive and lithographic manufacturing technologies using photopolymerisation provide a powerful tool for fabricating multiscale structures, which is especially interesting for biomimetic scaffolds and biointerfaces. However, most resins are tailored to one particular fabrication technology, showing drawbacks for versatile use. Hence, we used a resin based on thiol-ene chemistry, leveraging its numerous advantages such as low oxygen inhibition, minimal shrinkage and high monomer conversion. The resin is tailored to applications in additive and lithographic technologies for future biofabrication where fast curing kinetics in the presence of oxygen are required, namely 3D inkjet printing, digital light processing and nanoimprint lithography. These technologies enable us to fabricate scaffolds over a span of six orders of magnitude with a maximum of 10 mm and a minimum of 150 nm in height, including bioinspired porous structures with controlled architecture, hole-patterned plates and micro/submicro patterned surfaces. Such versatile properties, combined with noncytotoxicity, degradability and the commercial availability of all the components render the resin as a prototyping material for tissue engineers.

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Section: Resultsmentioning

confidence: 99%

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Kainz,

Perak,

Stubauer

et al. 2024

Polymers

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“…This description is based on the following references. [16][17][18][19][20][21] 2.1.1. Solvent Casing/Particle Leaching Solvent casting/particle leaching is one of the most common methods to prepare porous scaffolds with interconnection networks.…”

Section: Conventional Fabrication Methodsmentioning

confidence: 99%

Biomimetic Bilayered Scaffolds for Tissue Engineering: From Current Design Strategies to Medical Applications

Bertsch

Maréchal

Gribova

et al. 2023

Adv Healthcare Materials

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Tissue damage due to cancer, congenital anomalies, and injuries needs new efficient treatments that allow tissue regeneration. In this context, tissue engineering shows a great potential to restore the native architecture and function of damaged tissues, by combining cells with specific scaffolds. Scaffolds made of natural and/or synthetic polymers and sometimes ceramics play a key role in guiding cell growth and formation of the new tissues. Monolayered scaffolds, which consist of uniform material structure, are reported as not being sufficient to mimic complex biological environment of the tissues. Osteochondral, cutaneous, vascular, and many other tissues all have multilayered structures, therefore multilayered scaffolds seem more advantageous to regenerate these tissues. In this review, recent advances in bilayered scaffolds design applied to regeneration of vascular, bone, cartilage, skin, periodontal, urinary bladder, and tracheal tissues are focused on. After a short introduction on tissue anatomy, composition and fabrication techniques of bilayered scaffolds are explained. Then, experimental results obtained in vitro and in vivo are described, and their limitations are given. Finally, difficulties in scaling up production of bilayer scaffolds and reaching the stage of clinical studies are discussed when multiple scaffold components are used.

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“…[37,38] Hence the material's properties fall within the suitable range for applications in soft biomaterials, such as skin, nerve, and neuron tissue engineering, as indicated by previous studies. [39,40]…”

Section: Mechanical Characterizationmentioning

confidence: 99%

3D Inkjet Printing of Biomaterials with Solvent‐Free, Thiol‐Yne‐Based Photocurable Inks

Kainz,

Haudum,

Guillén

et al. 2024

Macro Materials & Eng

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Abstract3D inkjet printing is a fast, reliable, and non‐contact bottom–up approach to printing small and large models and is one of the fastest additive manufacturing technologies available. These attributes position inkjet printing as a promising tool for the additive manufacturing of biomaterials, for example, tissue engineering scaffolds. However, due to the stringent technical rheological requirements of current inkjet technologies, there is a lack of photopolymer resins suitable for the inkjet printing of biomaterials. Hence, a novel ink engineered for 3D piezoelectric inkjet printing of biomaterials is designed and developed. The novel resin leverages a biodegradable amino acid phosphorodiamidate matrix copolymerized with a dialkyne ether to modulate the viscosity. Copolymerization with commercially available thiols facilitates the photochemical thiol‐yne curing reaction. The ink exhibits optimal viscosity, eliminating the need for solvents, as well as reliable jetting and sufficiently swift curing kinetics. Furthermore, the formulation is successfully demonstrated in an industrial inkjet printhead. Notably, the resulting materials have low cytotoxicity and, hence, have significant promise in advancing the applications of 3D inkjet printing of biological scaffolds.

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Current Concepts and Methods in Tissue Interface Scaffold Fabrication

Cited by 13 publications

References 353 publications

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Biomimetic Bilayered Scaffolds for Tissue Engineering: From Current Design Strategies to Medical Applications

3D Inkjet Printing of Biomaterials with Solvent‐Free, Thiol‐Yne‐Based Photocurable Inks

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