Current challenges in European oncology pharmacy practice

Hoppe-Tichy, Torsten

doi:10.1177/1078155209354346

Cited by 26 publications

(10 citation statements)

References 30 publications

(36 reference statements)

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“…Among the various classes of pharmaceuticals, the anti-cancer drugs require a special attention because of an increasing demand for the chemotherapy treatment (Hoppe-Tichy, 2010 as high risk substances in regard of human health and considered as problematic for the environment because of their special properties in combination with poor biodegradability (Toolaram et al, 2014). Methotrexate (MTX) is a mutagen and a teratogen anticancer drug which belongs to the subgroup of the antimetabolites and acts by blocking enzyme activity and disrupting the DNA synthesis.…”

Section: Introductionmentioning

confidence: 99%

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

et al. 2015

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“…On the other hand, dose banding has no significant effect on patient throughput time, although it has been identified as a strategy for accelerating in-hospital turnaround time for commonly used preparations that contribute to enhanced daily patient capacity in oncology clinics (Hoppe-Tichy, 2009). There are several reasons why dose banding does not lead to a reduction in patient throughput time, such as the fact that it is only possible for drugs with sufficient long-term stability; sometimes, a mix of drugs with and without dose banding is used for patients who are receiving multiagent chemotherapy protocols.…”

Section: Discussionmentioning

confidence: 99%

Throughput efficiency and service quality after process redesign at a cancer day care unit: Two sides of the coin?

et al. 2018

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This study was designed to focus on the patient perspective in a reorganisation of care processes at a cancer day care unit (CDU). The effects of dose banding and of taking blood samples one day (or more) before the day care treatment (on Day −1) are investigated in terms of throughput efficiency and perceived service quality. Data were collected by mapping patient processes in detail and surveying patients in two CDUs at a university hospital (n = 308). A univariate model was used to investigate the effect of these factors on patient throughput time, and perceived service quality was examined with multiple linear regression. Taking blood samples on Day −1 decreases patient throughput time and increases the perceived service quality by improving the patient's perception of technical expertise and the outcome. This has a globally positive effect on patients' perceived service quality. Dose banding affected neither patient throughput time nor perceived service quality. Taking the pretreatment blood sample on Day −1 can be considered an important process design characteristic, as it increases both efficiency and service quality.

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“…This last decade, there are increasing needs for cytotoxic drug preparation due to the increasing number of cancers treated correlated to the increasing aging of people [1]. This will become problematic issue to be afforded by hospital pharmacies where the preparation of cytotoxic drugs has to be performed due to risk of occupational exposure [2].…”

Section: Introductionmentioning

confidence: 99%

Microbiological stability tests with simulated broth preparations and integrity testing for sterile standard cytotoxic preparations

Matheron

Guerault

Vazquez

et al. 2020

Pharmaceutical Technology in Hospital Pharmacy

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ObjectivesThe objectives were to assess the microbiological stability and the physical enclosure integrity of the overwrapping for batch production of standard cytotoxic injectable solutions.MethodsBroth culture media were used in place of cytotoxic drugs to assess the worst case in term of microbiological contamination risk. Iterative sterility tests on batches were performed for 60 days using rapid microbiological method. Validation of microbiological growth of culture media was assessed by direct inoculation of <100 CFU/mL of six microbiological strains recommended by European Pharmacopeia. Validation of the ability of growth of microorganisms in 11 cytotoxic solutions and one monoclonal antibody was assessed using eight strains. In addition, the physical integrity of the seal of the overwrapping containing cytotoxic preparations was assessed by dynamometric method and dye penetration test.ResultsNo microbiological contamination was observed on all units of batches for 60 days of investigation. The ability to detect microbiological growth in cytotoxic solutions was validated for the eight challenge microorganisms after 1/10 dilution for cytotoxic investigated, except for 5 Fluorouracil, gemcitabine and cisplatin. In addition, physical integrity testing of the seal of overwrapping pointed out the need of specific validation of heatsealer and operator education.ConclusionsBesides physico-chemical testing, microbiological stability testing combined to physical integrity testing is the additional part of the development method for batch production of sterile drugs in hospital.

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Current challenges in European oncology pharmacy practice

Cited by 26 publications

References 30 publications

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

Removal of the anti-cancer drug methotrexate from water by advanced oxidation processes: Aerobic biodegradation and toxicity studies after treatment

Throughput efficiency and service quality after process redesign at a cancer day care unit: Two sides of the coin?

Microbiological stability tests with simulated broth preparations and integrity testing for sterile standard cytotoxic preparations

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