Current challenges in clay minerals for drug delivery

Viseras, César; Cerezo, Pilar; Sánchez, R.; Salcedo, I.; Aguzzi, Carola

doi:10.1016/j.clay.2010.01.007

Cited by 311 publications

(154 citation statements)

References 25 publications

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“…191 Although pristine silicates have been widely used as carriers of several drugs, polysaccharide-clay hybrids offer more advantages related to the enhanced stability of drug-loaded hybrid suspensions, higher drug encapsulation efficiency, modulation of ion exchange behaviour, swelling capacity or improved cellular uptake. 192 The non-cytotoxicity of polysaccharide-silicate nanoparticles has been also confirmed, as in the case of quaternized chitosan/clay nanocomposites, which were successfully applied for delivery of proteins 193 and also as a novel non-viral gene carrier, affording good transfection efficiency in both in vitro and in vivo experiments. 194 Clay minerals assembled to polysaccharides afford suitable materials for application in regenerative medicine, being provided with good mechanical properties and biocompatibility, and are an alternative to commonly employed hydroxyapatite (HAP) and other calcium phosphates.…”

mentioning

confidence: 86%

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

2011

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mentioning

confidence: 86%

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

2011

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“…5 MMT has been used recently as an excipient in pharmaceutical applications, including transdermal formulations, tablets for oral administration, and as an extended release agent for tablets. [6][7][8][9][10] Furthermore, inclusion of photodegradable drug molecules within MMT may increase the photostability. 11 In this context, we further explore possible use of 3 MMT as a pharmaceutical excipient.…”

Section: Introductionmentioning

confidence: 99%

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

et al. 2016

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This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic low-molecular-weight compound lactose commonly used in pharmaceutical drug delivery, food technology, and flavoring. Nanocomposites were prepared under slow and fast drying conditions, attained by drying at ambient conditions and by spray-drying, respectively. A detailed structural investigation was performed with modulated differential scanning calorimetry, powder X-ray diffraction, solidstate nuclear magnetic resonance, scanning electron microscopy, microcalorimetry, and molecular dynamic simulations. The lactose was intercalated in the sodium montmorillonite interlayer space regardless of the clay content, drying rate, or humidity exposure. Although, the spray-drying resulted in higher proportion of intercalated lactose compared with the drying under 2 ambient conditions, non-intercalated lactose was present at 20 wt% lactose content. This indicates limitations in maximum load capacity of nonionic organic substances into the montmorillonite interlayer space. Furthermore, a fraction of the intercalated lactose in the cospray-dried nanocomposites diffused out from the clay interlayer space upon humidity exposure.Also, the lactose in the nanocomposites demonstrated higher molecular mobility than that of neat amorphous lactose. This study provides a foundation for understanding functional properties of nanocomposites, such as loading capacity and physical stability.

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“…As argilas já podem ser encontradas em diversos medicamentos como componentes fundamentais, seja como excipiente ou até mesmo como insumo farmacêutico ativo (IFA), já que algumas argilas também possuem atividade biológica [3,21].…”

Section: Argilas Tubularesunclassified

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

Silva¹,

Vilarinho²,

Barud

et al. 2016

Matéria (Rio J.)

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RESUMONas últimas décadas o uso de argilominerais nas áreas de Ciência e Engenharia de Materiais tem recebido notória atenção para a sua utilização no carreamento de fármacos. Dentre os diversos tipos de argilas, as fibrosas e as tubulares tem sido utilizadas na preparação de bionanocompósitos, devido as suas propriedades inerentes, como exemplo a elevada área superficial. Esta pesquisa visou o levantamento bibliográfico da utilização das argilas tubulares e fibrosas para o carreamento de fármacos. A busca por artigos foi realizado no banco de dados Web of Science, utilizando combinação dos termos: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, Imogolite and drug delivery, Palygoskite and drug delivery e Sepiolite and drug delivery. Foram encontrados o total de 36 artigos durante a pesquisa. Observouse que a maioria dos artigos utilizam as argilas em combinação com outros materiais (com formação de compósitos e blendas), principalmente polímeros, a fim de expandir as propriedades que melhoram a vetorização de insumos farmacêuticos ativos (IFAs), tais como a modificação do tamanho dos poros, do pH, da energia de ligação entre as moléculas, entre outros. Assim, evidencia-se que o interesse pela utilização das argilas no campo terapêutico tem aumentado, mostrando a relevância de pesquisas na área de medicamentos e materiais.Palavras-chave: argila fibrosa, argila tubular, argilominerais, carreamento de fármacos. ABSTRACTIn recent decades the use of clay minerals in the areas of Materials Science and Engineering has received notable attention for its use in carrying of drugs. Among the various types of clay, and fibrous tubes have been used in the preparation of bionanocompósitos due to their inherent properties, for example high surface area. This research aimed a review at the literature of the use of tubular and fibrous clays for the carrying of drugs. The search for articles was conducted in the Web of Science database, using combination of terms: Fibrous Clay and drug delivery, Tubular Clay and drug delivery, Halloysite and drug delivery, imogolite and drug delivery, drug delivery and Palygoskite and Sepiolite and drug delivery. Found total of 36 articles during the search. It was observed that most of the clay articles used in combination with other materials (with formation of composites and blends), in particular polymers in order to extend the properties that improve the vectoring of active pharmaceutical ingredients (APIs), such as modification pore size, the pH, the binding energy between molecules, among others. Thus, it is clear that the interest in the use of clays in the therapeutic field has increased, showing the relevance of research in the area of drugs and materials.

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Current challenges in clay minerals for drug delivery

Cited by 311 publications

References 25 publications

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

Hybrid and biohybrid silicate based materials: molecular vs. block-assembling bottom–up processes

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

Utilização de argilas fibrosas e tubulares para a liberação modificadas de fármacos: uma revisão

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