Current Cannabidiol Safety: A Review

Minocha, Neha; Singh, Chander; Rao, Komal; Yadav, Nikita; Vashist, Yogesh; Chugh, Palak; Bansal, Nidhi

doi:10.2174/1574886317666220902100511

Cited by 7 publications

(6 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of cannabis formulations has been associated with psychosis, dependence, abuse potential, behavioral disorders, and adverse effects on physical and mental health. [ 28 ] It has also been designated as a substance use disorder under the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Cannabis use disorder has been attributed to increased hospitalization and overall healthcare-associated expenditure.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Cannabinoids in anesthesia and chronic pain: Where do we stand?

Pandey,

Hoda

2024

Saudi Journal of Anaesthesia

View full text Add to dashboard Cite

Cannabis derivatives have been conventionally employed globally for their curative and restorative properties for various ailments. However, its recreational use and consequent legal restrictions have substantially cramped its scientific research. An emerging interest regarding the profound therapeutic potential of cannabinoids has been observed among clinicians. Despite a rich cultural background, high-quality research on cannabinoids is lacking in the Indian scenario. This review readdresses the challenges on this front and brings an insight into the current status of cannabinoids and their utility in scientific exploration. Cannabinoids have a significant medicinal value in various clinical disorders. Its use so far has been based on scarce resources and corroborations, as evidence-based substantiation is limited. Through this review article, we emphasize the remarkable role enacted by cannabinoids in the treatment of various clinical disorders and an utterly significant need to formulate stringent research methodologies to promote its systematic investigation.

show abstract

Section: Mechanism Of Actionmentioning

confidence: 99%

Cannabinoids in anesthesia and chronic pain: Where do we stand?

Pandey,

Hoda

2024

Saudi Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Other participants in the experiment expressed some doubts and reservations related to the safety, dosage, and quality of cannabidiol products. The safety of this plant extract has already been the subject of debate, and in some cases, its effectiveness has been questioned [6]. This indicated the need for further research to determine the efficacy and safety of cannabidiol in medicine.…”

Section: Analysis Of Chemical Pharmacodynamic and Pharmacokinetic Fea...mentioning

confidence: 99%

“…Cannabidiol interacts with a variety of neurotransmitter systems, including serotonin and opioid receptors, which can affect a variety of aspects of neural activity and body physiology. Regarding serotonin receptors, some studies indicate that CBD can interact with 5-HT1A receptors, which are responsible for controlling mood, sleep, and other mental functions [6,12,24]. This may partially explain the anxiolytic (anti-anxiety) and antineuropathic properties of CBD.…”

Section: Notes: Cbd -Cannabidiolmentioning

confidence: 99%

Pharmacological and morphological features and socioeconomic aspects of cannabidiol: A literature review

Hasiuk

2023

ijmmr

View full text Add to dashboard Cite

The relevance of detailed analysis of the available scientific research on the effects of cannabidiol on the human body is determined by the growing popularity of the non-psychoactive substance in cannabis products as a medicine. The research aimed to collect and systematise information about the positive and negative effects of cannabidiol, as well as the possibilities of its use in medicine. An analysis of 3375 scientific articles, publications and reports was conducted, of which 68 were selected that best met the terms of the request. The collected data was summarised and presented in a structured format. The results of the review indicate the remarkable pharmacological potential of cannabidiol, which can be used as a promising therapeutic agent in various medical fields. In the studies reviewed, cannabidiol showed anticonvulsant and antiepileptic effects, as well as a positive impact on drug substitution programmes. However, the possibility of negative reactions and potentially harmful effects of cannabidiol was also noted: it can lead to the development of psychological and physical dependence; increases the risk of physiological disorders, including the impact on spermatogenesis and disruption of the female microflora; affects behaviour and leads to developmental abnormalities. The effects of cannabidiol on the human body are still not well understood, and its distribution in the absence of sufficient legal regulation may pose a risk to the health and safety of consumers. Understanding all aspects of cannabidiol use will ensure proper management of its use and development of the relevant legislative framework, as well as facilitate further research and development of new drugs based on this plant extract

show abstract

“…It was believed earlier that vaping was safer than smoking because of no carbon monoxide component from heating. It also produced increased blood THC level and psychoactive effect, but recent reports say it causes more damage to the lungs [6].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Vaping & Cannabis usage results in a Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) incident in a Teenager with anxiety disorder: A case report

Jorge Pimentel,

Alessia Floriani,

Cesar Diaz

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

The recreational use of nicotine vaping and cannabis among teenagers has become increasingly prevalent in recent years, raising concerns about potential health risks. This case report highlights the association between prolonged toxic habits and the occurrence of a rare but severe cardiac event known as Non-ST-segment elevation myocardial infarction (NSTEMI) in a teenage individual. A comprehensive review of the patient's medical history, including cannabis and nicotine consumption patterns and cardiovascular risk factors, was conducted. The findings indicate a strong temporal relationship between prolonged cannabis and nicotine vaping usage and the development of an NSTEMI incident in this teenager. The pathophysiological mechanisms underlying this association are discussed, including the impact of cannabis on cardiovascular function, its potential to induce arterial vasoconstriction, and its prothrombotic effects. Additionally, the role of coexisting risk factors, such as anxiety, is mentioned to elucidate their contribution to the development of NSTEMI. The implications of this case highlight the need for increased awareness among healthcare professionals, educators, and parents regarding the potential cardiovascular risks associated with prolonged cannabis usage in teenagers. Early identification of cannabis use and prompt intervention are crucial to prevent life-threatening cardiac events in susceptible individuals. Further research is warranted to explore the precise mechanisms linking cannabis use and NSTEMI incidents, enabling the development of targeted preventive strategies and evidence-based interventions to mitigate the potential harm caused by cannabis consumption in the adolescent population. Categories: Cardiology; Emergency Medicine; Internal Medicine

show abstract

Current Cannabidiol Safety: A Review

Cited by 7 publications

References 64 publications

Cannabinoids in anesthesia and chronic pain: Where do we stand?

Cannabinoids in anesthesia and chronic pain: Where do we stand?

Pharmacological and morphological features and socioeconomic aspects of cannabidiol: A literature review

Prolonged Vaping & Cannabis usage results in a Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) incident in a Teenager with anxiety disorder: A case report

Contact Info

Product

Resources

About