Current Arterial Prostheses

Sauvage, Lester R.; Walker, Melissa J.; Berger, K; Robel, Stephen B.; Lischko, Michael M.; Yates, Stanley G.; Logan, Gordon A.

doi:10.1001/archsurg.1979.01370300041005

Cited by 112 publications

(6 citation statements)

References 3 publications

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“…But on the other hand, it will further decrease the velocity of slow moving blood in the vein system and part of the flow may become stagnant. Consequently, the blood velocity is highly susceptible where below the “thrombotic threshold velocity”, which leads to thrombus accumulation on the graft or vessel surface, and finally results in occlusion 22 . Moreover, because the stagnation flow zones are associated with very low shear conditions and some parts of the vessel wall will be exposed to abnormally low WSS that means the fluid shearing forces of the blood will not be sufficient to overwhelm the forces associated with cell–cell interactions.…”

Section: Discussionmentioning

confidence: 99%

Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Peng

Qiu

Huang

et al. 2017

Sci Rep

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The tunneled central venous catheter (CVC) plays an important role for hemodialysis patients, but CVC-related thrombosis in the central veins remain problematic. This study is the first try to numerically find out what hemodynamic parameters are predisposed to the initiation and formation of thrombus after CVC insertion. And the potential relationship between hemodynamic parameters and the incidence rates of thrombosis occurrence was explored. The results revealed that the CVC insertion led to a significant increase of hydraulic resistance, wide-ranging abnormally high wall shear stress (WSS), and a great loss of flow rotation in the vein. Moreover, the clinical data showed that thrombosis mainly occurred at sections where most blood flow lost spiral rotation after the CVC insertion, but no corresponding match was observed between the occurrence of thrombosis and the flow velocity or WSS. We speculate that the destruction of the flow rotation in the central vein is a precursor to the thrombus formation around CVC, and an introduction of spiral flow with the CVC insertion may possibly help to protect the central vein from thrombosis. Further animal and clinical experiments should be carried out to test and verify this speculation.

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Section: Discussionmentioning

confidence: 99%

Numerical Simulation of Hemodynamic Changes in Central Veins after Tunneled Cuffed Central Venous Catheter Placement in Patients under Hemodialysis

Peng

Qiu

Huang

et al. 2017

Sci Rep

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“…Sauvage et al [15] developed a model to study the thrombogenicity of graft materials for arterial substitutes and found a good cor relation with their long-term performance. A modification of their method was used in our study to determine the adhesion and aggrega tion of platelets in vivo, and the accumula tion of fibrinogen on the grafts tested using 5lCr-labelled platelets and l25I-fibrinogen, re spectively.…”

Section: Discussionmentioning

confidence: 99%

“…It seems that the binding of heparin to endothelial cells depends on the concentration of the heparin solution and to a lesser degree on the time of incubation [9,10]. Sauvage et al [15] compared several prosthetic materials and during 6 h of obser vation found that the TFS of umbilical veins flushed with a heparinized solution was ap proximately 13% at a blood flow rate of 50 ml/min.…”

Section: Discussionmentioning

confidence: 99%

Decreased Acute Thrombogenicity of Human Umbilical Veins after Heparin and Alcohol Treatment

et al. 1983

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Nine glutaraldehyde-tanned human umbilical veins (GAUV) were incubated in heparin followed by storage in ethyl alcohol 50% (HAUV). These grafts were compared to five GAUV flushed with a heparinized solution without subsequent treatment in alcohol (HsAUV) and four nonheparinized GAUV (NHUV) placed in the contralateral carotid arteries of dogs for approximately 3 h. The thrombogenicity was evaluated by measuring the platelet adhesion and aggregation (⁵¹Cr), fibrinogen accumulation (¹²⁵I-fibrinogen), the thrombus-free surface and the thrombus weight. The HAUV had the lowest ⁵¹Cr radioactivity. The means of thrombus-free surface and thrombus weight for the grafts were as follows: HAUV, 82% and 0.3 g (n = 9); HsAUV, 53% and 0.6 g (n = 5); NHUV, 13% and 1.2 g (n = 4). The HAUV showed a lower thrombogenicity than both the NHUV and the HsAUV grafts.

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“…17 When bypass grafts are carried to the vessels in the mid-calf and below, significantly lower flow may also result. Bandyk et al 18 and Sauvage et al 19 have noted the importance of a critical level of blood flow velocity in vein and prosthetic grafts below which thrombus formation may occur. These observations seem to support the potential usefulness of antithrombotic therapy for infrainguinal bypass grafts and especially for prosthetic grafts to tibial or peroneal arteries.…”

Section: Discussionmentioning

confidence: 99%