Current approaches and perspectives in the therapy of medullary thyroid carcinoma

Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

“…In MTC, objective responses to other forms of therapy such as chemotherapy and radiotherapy are mostly insufficent, fewer than 20% (Petursson, 1988;Samaan et al, 1988;Wu et al, 1994;Brierley et al, 1996;Vitale et al, 2001). Therefore MTC represents an attractive target for alternative gene therapeutic strategies, of which ASODNs may be considered as one of choices.…”

Evaluation of potential mechanisms underlying genotype–phenotype correlations in multiple endocrine neoplasia type 2

“…The ability of cancer cells to evade apoptosis is known as an essential hallmark of cancer (Hanahan and Weinberg, 2000), and particularly in MTC, apoptosis resistance remains the major obstacle to effective chemotherapy (Vitale et al, 2001). Thus, we examined whether expression of mutant RET proteins in NIH3T3 cells can reduce their sensitivity to undergo apoptosis by chemotherapeutic drugs.…”

Response to [90Yttrium-DOTA]-TOC Treatment is Associated with Long-term Survival Benefit in Metastasized Medullary Thyroid Cancer: A Phase II Clinical Trial

“…Treatment with Adriamycin, cyclophosphamide, vincristine, dacarbazine, 5-fluorouracil, or combined regimes have shown only minor responses with considerable hematologic, nephrologic, cardiologic, or gastrointestinal toxicities (2,3). On the other hand, preliminary studies revealed encouraging results with radiolabeled anticarcinoembryonic antigen antibodies (4) and metaiodobenzylguanidine (5).…”