Current applications of poly(lactic acid) composites in tissue engineering and drug delivery

Liu, Shan; Qin, Shuhao; He, Min; Zhou, Dongshan; Qin, Qingdong; Wang, Hao

doi:10.1016/j.compositesb.2020.108238

Cited by 335 publications

(221 citation statements)

References 244 publications

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“…Some noticeable cytotoxicity (higher than 20% reduction of cell viability) can be seen in all studied polymers, included PLA, only after exposing the cells at high nanoparticle concentrations, i.e., higher than 800 μg/mL. Based on these results, it is clear that mPEG-PCL and the copolymer containing Fe-BTC are biocompatible and their biocompatibility is similar to that of PLA, a polymer of high biocompatibility which is extensively used in biomedical and pharmaceutical technology [ 50 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 96%

Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework

et al. 2020

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In the present work, the porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance the solubility of the anticancer drug paclitaxel (PTX) and to prepare controlled release formulations after its encapsulation in amphiphilic methoxy poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) nanoparticles. Investigation revealed that drug adsorption in Fe-BTC reached approximately 40%, a relatively high level, and also led to an overall drug amorphization as confirmed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The dissolution rate of PTX-loaded MOF was substantially enhanced achieving a complete (100%) release within four days, while the neat drug only reached a 13% maximum rate (3–4 days). This PTX-Fe-BTC nanocomposite was further encapsulated into a mPEG-PCL matrix, a typical aliphatic amphiphilic copolyester synthesized in our lab, whose biocompatibility was validated by in vitro cytotoxicity tests toward human umbilical vein endothelial cells (HUVEC). Encapsulation was performed according to the solid-in-oil-in-water emulsion/solvent evaporation technique, resulting in nanoparticles of about 143 nm, slightly larger of those prepared without the pre-adsorption of PTX on Fe-BTC (138 nm, respectively). Transmission electron microscopy (TEM) imaging revealed that spherical nanoparticles with embedded PTX-loaded Fe-BTC nanoparticles were indeed fabricated, with sizes ranging from 80 to 150 nm. Regions of the composite Fe-BTC-PTX system in the infrared (IR) spectrum are identified as signatures of the drug-MOF interaction. The dissolution profiles of all nanoparticles showed an initial burst release, attributed to the drug amount located at the nanoparticles surface or close to it, followed by a steadily and controlled release. This is corroborated by computational analysis that reveals that PTX attaches effectively to Fe-BTC building blocks, but its relatively large size limits diffusion through crystalline regions of Fe-BTC. The dissolution behaviour can be described through a bimodal diffusivity model. The nanoparticles studied could serve as potential chemotherapeutic candidates for PTX delivery.

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Section: Resultsmentioning

confidence: 96%

Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework

et al. 2020

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“…This characteristic is useful and leads to the utilisation of the polymer in a wide range of applications, especially as scaffolds for tissue engineering application and bone fixation purposes. In addition, PLA is a prospective drug delivery material due to its tailorable porosity for controlled adsorption and drug release [ 307 ].…”

Section: The History Contemporary Status and Future Applicationsmentioning

confidence: 99%

“…Preparation of PLA-based drug delivery methods include emulsification, nanoprecipitation, salting-out, spray-drying, and stable dispersion to achieve nano- and microparticles [ 312 ]. Incorporation of PLA actually serves as a biodegradable component since it is the most common FDA-approved biopolymer in many drug delivery systems [ 307 ]. In order to enable a tailored application, a composite is favoured over a single-material system.…”

Section: The History Contemporary Status and Future Applicationsmentioning

confidence: 99%

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Biomedical Applications of Bacteria-Derived Polymers

et al. 2021

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Plastics have found widespread use in the fields of cosmetic, engineering, and medical sciences due to their wide-ranging mechanical and physical properties, as well as suitability in biomedical applications. However, in the light of the environmental cost of further upscaling current methods of synthesizing many plastics, work has recently focused on the manufacture of these polymers using biological methods (often bacterial fermentation), which brings with them the advantages of both low temperature synthesis and a reduced reliance on potentially toxic and non-eco-friendly compounds. This can be seen as a boon in the biomaterials industry, where there is a need for highly bespoke, biocompatible, processable polymers with unique biological properties, for the regeneration and replacement of a large number of tissue types, following disease. However, barriers still remain to the mass-production of some of these polymers, necessitating new research. This review attempts a critical analysis of the contemporary literature concerning the use of a number of bacteria-derived polymers in the context of biomedical applications, including the biosynthetic pathways and organisms involved, as well as the challenges surrounding their mass production. This review will also consider the unique properties of these bacteria-derived polymers, contributing to bioactivity, including antibacterial properties, oxygen permittivity, and properties pertaining to cell adhesion, proliferation, and differentiation. Finally, the review will select notable examples in literature to indicate future directions, should the aforementioned barriers be addressed, as well as improvements to current bacterial fermentation methods that could help to address these barriers.

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“…Pennel et al [ 185 ] made a direct relation between the infiltration and vascularization ability of the new material and its continual stability. Liu et al [ 186 ] demonstrated that polylactide co-trim-ethylene carbonate nanofibers showed enhanced efficiencies as scaffold materials for tissue regeneration. Bao et al [ 187 ] developed multifunctional fibrous scaffolds with shape memory specification.…”

Section: Innovation In Biomimetic Design Materials Properties Anmentioning

confidence: 99%

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

et al. 2021

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Over the last twenty years, researchers have focused on the potential applications of electrospinning, especially its scalability and versatility. Specifically, electrospun nanofiber scaffolds are considered an emergent technology and a promising approach that can be applied to biosensing, drug delivery, soft and hard tissue repair and regeneration, and wound healing. Several parameters control the functional scaffolds, such as fiber geometrical characteristics and alignment, architecture, etc. As it is based on nanotechnology, the concept of this approach has shown a strong evolution in terms of the forms of the materials used (aerogels, microspheres, etc.), the incorporated microorganisms used to treat diseases (cells, proteins, nuclei acids, etc.), and the manufacturing process in relation to the control of adhesion, proliferation, and differentiation of the mimetic nanofibers. However, several difficulties are still considered as huge challenges for scientists to overcome in relation to scaffolds design and properties (hydrophilicity, biodegradability, and biocompatibility) but also in relation to transferring biological nanofibers products into practical industrial use by way of a highly efficient bio-solution. In this article, the authors review current progress in the materials and processes used by the electrospinning technique to develop novel fibrous scaffolds with suitable design and that more closely mimic structure. A specific interest will be given to the use of this approach as an emergent technology for the treatment of bacteria and viruses such as COVID-19.

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Current applications of poly(lactic acid) composites in tissue engineering and drug delivery

Cited by 335 publications

References 244 publications

Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework

Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework

Biomedical Applications of Bacteria-Derived Polymers

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

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