Current Applications for Nuclear Medicine Imaging in Pulmonary Disease

Kusmirek, Joanna; Magnusson, Josiah D.; Perlman, Scott

doi:10.1007/s13665-020-00251-1

Cited by 10 publications

(4 citation statements)

References 114 publications

(154 reference statements)

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“…Oral contrast may help distinguish bowel wall thickening [ 9 ]. Nuclear medicine scans like technetium-hexametazime or indium-label white blood cell scans help detect low-grade graft infections [ 10 , 11 ]. In our case, CTA showed a fusiform aneurysm of the arch of the aorta extending from the left subclavian to the origin of the superior mesenteric artery with an aortoesophageal fistula, which is covered by a thrombus.…”

Section: Discussionmentioning

confidence: 99%

Primary Aortoesophageal Fistula Presenting as Upper Gastrointestinal Bleed

Naik¹,

Shaikh²,

Kunjumohammed³

et al. 2022

Cureus

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Aortoenteric fistula is a rare condition that can be primary or secondary. The primary type is less common than the secondary. The secondary aortoenteric fistula is an uncommon fatal complication after reconstructive surgery for an aortic aneurysm or other aortic diseases. Here we present a case of a 59-yearold man who presented to our emergency department with sudden onset of massive hematemesis. Imaging studies were done and the patient was diagnosed to have aortoesophageal fistula. Upper gastrointestinal endoscopy showed an intraluminal bulge in the posterior wall of the esophagus with an ulcer and hematoma. The patient was planned for emergency surgical intervention, but the patient had recurrent bouts of hematemesis and, unfortunately, expired. Hence patients presenting with massive hematemesis, aortoenteric fistula can be the underlying cause, and all surgeons should be aware of such conditions and the need for emergent surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Primary Aortoesophageal Fistula Presenting as Upper Gastrointestinal Bleed

Naik¹,

Shaikh²,

Kunjumohammed³

et al. 2022

Cureus

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“…FDG PET has emerged as a non-invasive technique for diagnosing and monitoring infectious diseases. 29 In the setting of acute infection, neutrophils depend on anaerobic glycolysis to maintain cellular activity and glucose transporters are overexpressed in activated inflammatory cells, leading to increased FDG uptake. The pathophysiology of COVID-19 pneumonia involves the accumulation of alveolar macrophages and neutrophils due to immune host response and subsequent release of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

FDG PET/CT imaging features and clinical utility in COVID-19

et al. 2021

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Purpose To determine the imaging findings and potential clinical utility of FDG PET/CT in patients with laboratory-confirmed COVID-19. Methods We performed a single institution retrospective review of patients diagnosed with COVID-19 using real time reverse transcription–polymerase chain reaction (RT-PCR) who underwent FDG PET/CT for routine cancer care between March 1, 2020 to April 30, 2020, during the height of the pandemic in New York City, New York, United States. PET/CT scans were retrospectively reviewed for imaging findings suspicious for COVID-19. For positive scans, PET and CT findings were recorded, including location, FDG avidity (SUV max ) and CT morphology. Patient demographics and COVID-19 specific clinical data were collected and analyzed with respect to PET/CT scan positivity, lung SUV max , and time interval between PET/CT and RT-PCR. Results Thirty-one patients (21 males and 10 females, mean age 57 years ± 16) were evaluated. Thirteen of 31 patients had positive PET/CT scans, yielding a detection rate of 41.9%. Patients with positive scans had significantly higher rates of symptomatic COVID-19 infection (77% vs 28%, p = 0.01) and hospitalizations (46% vs. 0%, p = 0.002) compared to patients with negative scans. Eleven of 13 patients (84.6%) with positive scans had FDG-avid lung findings, with mean lung SUV max of 5.36. Six of 13 patients (46.2%) had extrapulmonary findings of FDG-avid thoracic lymph nodes. The detection rate was significantly lower when the scan was performed before RT-PCR versus after RT-PCR (18.8% ( n = 3/16) vs. 66.7% ( n = 10/15), p = 0.009). Lung SUV max was not associated with COVID-19 symptoms, severity, or disease course. Conclusion FDG PET/CT has limited sensitivity for detecting COVID-19 infection. However, a positive PET scan is associated with higher risk of symptomatic infection and hospitalizations, which may be helpful in predicting disease severity.

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“…This is very important, where different diseases may have the same appearance on other modalities and more specific tests would be valuable. 59 In both imaging modalities, clinical application and diagnostic imaging have been applied in the same perspective. Availability of a variety of probes and strategies confer PET a high degree of versatility.…”

Section: Veterinary Nuclear Medicine Imagingmentioning

confidence: 99%

Application of Advanced Imaging Modalities in Veterinary Medicine: A Review

Yitbarek¹,

Dagnaw²

2022

VMRR

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Veterinary anatomy has traditionally relied on detailed dissections to produce anatomical illustrations, but modern imaging modalities, now represent an enormous resource that allows for fast non-invasive visualizations in living animals for clinical and research purposes. In this review, advanced anatomical imaging modalities and their applications, safety issues, challenges, and future prospects of the techniques commonly employed for animal imaging would be highlighted. The quality of diagnostic imaging equipment in veterinary practice has greatly improved. Recent advances made in veterinary advanced imaging specifically about cross-sectional modalities (CT and MRI), nuclear medicine (PET, SPECT), and dual imaging modalities (PET/CT, PET/MR, and SPECT/CT) have become widely available, leading to greater demands and expectations from veterinary clients. These modalities allow for the creation of three-dimensional representations that can be of considerable value in the dissemination of clinical diagnosis and anatomical studies. Despite, the modern imaging modalities well established in developed countries across the globe, it is yet to remain in its infancy stage in veterinary practice in developing countries due to heavy initial investment and maintenance costs, lack of expert interpretation, a requirement of specialized technical staff and need of adjustable machines to accommodate the different range of animal sizes. Therefore, veterinarians should take advantage of these imaging techniques in designing future experiments by considering the availability of these varied imaging modalities and the creation of three-dimensional graphical representations of internal structures.

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Current Applications for Nuclear Medicine Imaging in Pulmonary Disease

Cited by 10 publications

References 114 publications

Primary Aortoesophageal Fistula Presenting as Upper Gastrointestinal Bleed

Primary Aortoesophageal Fistula Presenting as Upper Gastrointestinal Bleed

FDG PET/CT imaging features and clinical utility in COVID-19

Application of Advanced Imaging Modalities in Veterinary Medicine: A Review

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