Current application status of multi-scale simulation and machine learning in research on high-entropy alloys

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

“…23−26 Therefore, SLM-printed implants have a lower Young's modulus than conventional orthopedic implants produced by direct machining of alloy rods. 27,28 In this study, the pedicle screws were designed to be fully through-hole and were fabricated by SLM 3D printing to improve cell ingrowth and accelerate osseointegration. 29 This work also paves a new method for the development of high-performance orthopedic surgery implants.…”

“…Current Ti6Al4V implants have a dense, solid matrix that allows cells and tissues to extend only to the surface of the implant but not to grow into the implant, increasing the risk of fixation failure due to bone resorption and decreased bone density around the implant interfaces . Currently, there is a gowing demands for metallic load-bearing implants employed in the field of orthopedics, such as hip and knee joint replacements, vertebral body reconstruction, and orthodontics. , How to improve the adaptation of mechanical properties of orthopedics metallic implants to promote osteointegration is the key issue. , Previous studies have optimized the mechanical properties of Ti-based scaffolds via introducing porous structure and 3D printing methods. , SLM printing technique generates 3D constructs from molten metal powders, and micropores formed in the workpieces due to the gas trapping and incomplete remelting. − Therefore, SLM-printed implants have a lower Young’s modulus than conventional orthopedic implants produced by direct machining of alloy rods. , In this study, the pedicle screws were designed to be fully through-hole and were fabricated by SLM 3D printing to improve cell ingrowth and accelerate osseointegration . This work also paves a new method for the development of high-performance orthopedic surgery implants.…”