Current application of chemometrics in traditional Chinese herbal medicine research

Huang, Yipeng; Wu, Zhenwei; Su, Rihui; Ruan, Guihua; Du, Fuyou; Li, Gongke

doi:10.1016/j.jchromb.2015.12.050

Cited by 50 publications

(36 citation statements)

References 99 publications

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“…Compared with chemical drug, traditional Chinese medicine (or herbal medicine) is characteristic of multi-component with multitarget, which brings a great challenge for quality control [7]. Usually, some components are chosen as indicators for quality control, however, they can hardly express the information of the preparation fully.…”

Section: Discussionmentioning

confidence: 99%

Stability and drug dissolution evaluation of Qingkailing soft/hard capsules based on multi-component quantification and fingerprint pattern statistical analysis

Sun¹,

Teng²,

Chen³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Stability and drug dissolution evaluation of Qingkailing soft/hard capsules based on multi-component quantification and fingerprint pattern statistical analysis

Sun¹,

Teng²,

Chen³

et al. 2017

Trop. J. Pharm Res

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“…For this purpose, it is possible to use classification algorithms that allow to distinguish between various products in an efficient and precise way, based only on their chemical profiles. Up to now, many papers have reported possibility of classifying natural bioactive herbal compositions of various complexity—eg …”

Section: Introductionmentioning

confidence: 99%

“…Up to now, many papers have reported possibility of classifying natural bioactive herbal compositions of various complexity-eg. [20][21][22][23][24][25][26][27][28] LAPV technique 29,30 -large amplitude pulse voltammetry-is an analytical technique based on voltammetric measurements under conditions of temporary cyclic polarization of the working electrode. It is based on application of only dozen of pulses with a constant duration enlarged or reduced by a certain constant voltage value.…”

Section: Introductionmentioning

confidence: 99%

Classification of six herbal bioactive compositions employing LAPV and PLS‐DA

Górski

Kowalcze

Jakubowska

2019

Journal of Chemometrics

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Numerous medical herbal products available on the market require development of fast and cheap strategies of authenticity control. Such method may be large amplitude pulse voltammetry (LAPV) with boron‐doped diamond electrode (BDDE), combined with chemometric supervised method—partial least squares discriminant analysis (PLS‐DA). The voltammetric method was used to gather the chemical profiles, required to prepare PLS‐DA multivariate classification model. The proposed methodology was successfully applied to classify six ethanol herbal compositions (with content analogous to the commercial products) and provided reliable classification model (without misclassifications).

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“…Samples are grouped on the basis of similarity without considering information about class membership. Principal component analysis (PCA) removes redundancy and noise while retaining meaningful information . Using chemometrics, particular herbal preparations with complex components could be rapidly distinguished basing on either species, geographic origins, qualities, pretreatments, or toxicities .…”

Section: Introductionmentioning

confidence: 99%

“…Principal component analysis (PCA) removes redundancy and noise while retaining meaningful information. [15] Using chemometrics, particular herbal preparations with complex components could be rapidly distinguished basing on either species, [16] geographic origins, [17] qualities, [18] pretreatments, [19] or toxicities. [20] The application of the analytical techniques with chemometric methods is a leading approach for shortening analysis and product development time.…”

Section: Introductionmentioning

confidence: 99%

Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Chang

Tung

Tsai

et al. 2016

Drug Testing and Analysis

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Hemp nuts are mature cannabis seeds obtained after shelling and that are commonly used in traditional Chinese medicine for treating functional constipation. In this work, we screened hemp nut products, classified them, and verified the legality of consuming them. A total of 18 products were purchased from Taiwan, China, and Canada. Validated high-performance liquid chromatography with tandem mass spectrometry methods were developed for analyzing the cannabinoid (i.e., Δ -tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol) content of the products and the concentration of urinary 11-nor-9-carboxy-THC. Chemometric techniques, namely hierarchical clustering analysis (HCA) and principal component analysis (PCA), were applied for rapidly classifying 11 concentrated powder products in Taiwan. A pilot human study comprising single and multiple administrations of a product with 1.5 µg/g of THC was conducted to examine the urinary 11-nor-9-carboxy-THC concentration. Through optimization of 3 full factorial design, using 60% isopropanol as the extraction solvent exhibited the highest yield of cannabinoids and was applied as the optimal condition in further analysis. The results of HCA and PCA on quality evaluation were in good agreement; however, the tested products possessed distinct CBD-to-THC ratios which ranged widely from 0.1:1 to 46.8:1. Particularly, the products with CBD-to-THC ratios higher than 1:1 were the majority in Taiwan. Our data suggested that all the tested hemp nut products met the Taiwan restriction criterion of 10 µg/g of THC. We propose a usual consumption amount of hemp nut products in Taiwan would unlikely to violate the cut-off point of 15 ng/mL of urinary 11-nor-9-carboxy-THC. Copyright © 2016 John Wiley & Sons, Ltd.

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Current application of chemometrics in traditional Chinese herbal medicine research

Cited by 50 publications

References 99 publications

Stability and drug dissolution evaluation of Qingkailing soft/hard capsules based on multi-component quantification and fingerprint pattern statistical analysis

Stability and drug dissolution evaluation of Qingkailing soft/hard capsules based on multi-component quantification and fingerprint pattern statistical analysis

Classification of six herbal bioactive compositions employing LAPV and PLS‐DA

Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

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