Current and Future Promises of Transgenesis for Agricultural Livestock in a Global Marketplace

Bremel, Robert D.; Homan, E. Jane; Howard, Trevor

doi:10.3168/jds.s0022-0302(01)70190-7

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…Several reviews examine the possibility of using transgenic animals in Agriculture (Niemann et al, 2005;Kues, 2000, 2003;Houdebine, 2003;Bremel et al, 2001;Wheeler, 2003;Montaldo, 2006). It has been said that this is a field in which there are more reviews about the possible use and future of transgenesis than actual papers with data.…”

Section: Transgenic Animalsmentioning

confidence: 96%

“…In the next 16 years, products created by that technology will likely be in the hands of consumers". Bremel et al (2001): "The overwhelming challenge to agriculture in the next century will be to feed a huge population while creating and maintaining sustainable agricultural systems. Biotechnology, including transgenic livestock, will play a key role in meeting this challenge".…”

Section: Transgenesismentioning

confidence: 99%

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The role of genetic engineering in livestock production

Blasco

2008

Livestock Science

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Section: Transgenic Animalsmentioning

confidence: 96%

Section: Transgenesismentioning

confidence: 99%

The role of genetic engineering in livestock production

Blasco

2008

Livestock Science

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“…These examples include local versus systemic control of mammary development and function as illustrated by the wallaby and seals (Brennan et al, 2007), evolutionary and comparative aspects of lactation (Blackburn, 1993;Oftedal, 1993), and endocrine and growth factor species variation (Forsyth, 1986(Forsyth, , 1996. Others have described new frontiers for the mammary gland (Bremel et al, 2001;Hadsell et al, 2002), including the mammary gland as bioreactor, and transgenic animals Donovan et al, 2001).…”

Section: Measuring Hormones and Growth Factors And Their Receptorsmentioning

confidence: 99%

A 100-Year Review: Mammary development and lactation

Akers

2017

Journal of Dairy Science

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What is old is new again-and with respect to the study of the mammary development and function in dairy animals, the expression resonates. Many of the mammary and milk production questions raised in the early years of the Journal of Dairy Science apply today. To be sure, scientists have filled in many details regarding, for example, identification of hormones and growth factors important in the control of mammary growth, the onset of copious milk production at calving, and maintenance of lactation. Early years focused on identification and subsequent availability of classic mammogenic, lactogenic, and galactopoietic hormones (e.g., steroids, prolactin, and growth hormone). The advent of sensitive assays to measure concentrations of these hormones and, subsequently, myriad growth factors in blood, milk, and tissues, allowed creation of multiple hypotheses to explain mammary cell proliferation and regulation of function. It is also apparent that we understand many of the fundamentals of milk removal, milking frequency, milking management, and milk ejection for successful lactation. However, some questions remain. Are the principles that were identified when cows produced markedly less milk still valid for the high-producing cows of today and the future? What mechanism(s) explain the positive effects of early increased milking frequency on subsequent milk production? Can the persistency of lactation be improved (secretory cell number vs. secretory cell function) or does early management "program" future mammary development or productivity (epigenetics, immune responsiveness, other)? The explosion of tools and techniques (Southern and Northern blots, PCR, and the "-omics" revolution) has driven an almost overwhelming evaluation of cellular and molecular functions in the mammary gland and other tissues. One key may be the discovery of a "Rosetta stone" that will allow understanding of this mass of detailed information on gene expression, cell signaling, and so on. Many scientists can now better appreciate the difficulty of the dairy farmer seeking to process DHIA or Dairy Comp 305 data, milking data, weights, feeding reports, pedometer readings, or genomic evaluations to manage their operations.

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