Current and future perspectives of genetically modified organisms in North America

Ijaz, Usman; Shafique, Aimen; Hasnain, Nayab; Babar, Naeem Iqbal; Zameer, Roshan; Azeem, Farrukh

doi:10.1016/b978-0-12-823903-2.00008-1

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…However, these advanced genetic engineering techniques still face various challenges, including modularity, epigenetics, high complexity, standardization, difficulties in characterization, and the risk of accidental release into wild species. Moreover, genetic modification is an irreversible process, raising significant social concerns [ 200 , 201 ].…”

Section: Strategies To Exploit Innate Immune Responses Of the Host Fo...mentioning

confidence: 99%

Molecular Basis of Plant–Pathogen Interactions in the Agricultural Context

Ijaz,

Zhao,

Shabala

et al. 2024

Biology

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Biotic stressors pose significant threats to crop yield, jeopardizing food security and resulting in losses of over USD 220 billion per year by the agriculture industry. Plants activate innate defense mechanisms upon pathogen perception and invasion. The plant immune response comprises numerous concerted steps, including the recognition of invading pathogens, signal transduction, and activation of defensive pathways. However, pathogens have evolved various structures to evade plant immunity. Given these facts, genetic improvements to plants are required for sustainable disease management to ensure global food security. Advanced genetic technologies have offered new opportunities to revolutionize and boost plant disease resistance against devastating pathogens. Furthermore, targeting susceptibility (S) genes, such as OsERF922 and BnWRKY70, through CRISPR methodologies offers novel avenues for disrupting the molecular compatibility of pathogens and for introducing durable resistance against them in plants. Here, we provide a critical overview of advances in understanding disease resistance mechanisms. The review also critically examines management strategies under challenging environmental conditions and R-gene-based plant genome-engineering systems intending to enhance plant responses against emerging pathogens. This work underscores the transformative potential of modern genetic engineering practices in revolutionizing plant health and crop disease management while emphasizing the importance of responsible application to ensure sustainable and resilient agricultural systems.

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Section: Strategies To Exploit Innate Immune Responses Of the Host Fo...mentioning

confidence: 99%

Molecular Basis of Plant–Pathogen Interactions in the Agricultural Context

Ijaz,

Zhao,

Shabala

et al. 2024

Biology

Self Cite

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Section: Nanohyrbid-induced Plant Disease Resistancementioning

confidence: 99%

“…Emphasizing food safety over the incorporation of new properties and traits is crucial. However, concerns exist regarding the ecological hazards and potential health risks associated with genetically modified crops intended for human consumption [178]. For instance, 'Starlink' maize, engineered to express Cry9c, was approved for industrial use and animal feed in the USA but not for human consumption due to elevated protein levels and potential immune system interactions [185].…”

Section: Food Safety Issuesmentioning

confidence: 99%

Molecular Basis of Plant-Pathogen Interaction in the Agriculture Context

Ijaz,

Zhao,

Shahbala

et al. 2024

Preprint

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Biotic stressors pose serious threats to crop yield, jeopardizing food security and resulting in over US$220 billion per year losses to the agriculture industry. Plants activate innate defense mechanisms upon pathogen perception and invasion. The plant immune response comprises numerous concerted steps, including the recognition of invading pathogens, signal transduction, and activation of defensive pathways. However, pathogens have evolved various structures to evade plant immunity. Given these facts, genetic improvements of plants are required for sustainable disease management to ensure global food security. Advanced genetic technologies have provided new opportunities to revolutionize and boost plant disease resistance against devastating pathogens. Furthermore, targeting susceptibility (S) genes, such as OsERF922 and BnWRKY70, through CRISPR methodologies offers novel frontiers to disrupt the molecular compatibility of pathogens and introduce durable resistance against them in plants. Here, we provide a critical overview of advances in understanding disease resistance mechanisms. The review also critically examines management strategies under challenging environmental conditions and R gene-based plant genome engineering systems intending to enhance plant responses against emerging pathogens. This work underscores the transformative potential of modern genetic engineering practices in revolutionizing plant health and crop disease management while emphasizing the importance of responsible application to ensure sustainable and resilient agricultural systems.

show abstract