Current and emerging treatment strategies for hair loss in women of color

Okereke, Uchenna; Simmons, Anne; Callender, Valerie D.

doi:10.1016/j.ijwd.2018.10.021

Cited by 23 publications

(13 citation statements)

References 55 publications

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“…Other treatments include tetracyclines, hydroxychloroquine, oral and topical minoxidil, calcineurin inhibitors, mycophenolate, cyclosporine, thalidomide, and topical metformin. 5 , 6 , 10 , 11 However, these treatments often have suboptimal efficacy and are frequently associated with complications.…”

Section: Introductionmentioning

confidence: 99%

Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

Umar¹,

Kan²,

Carter³

et al. 2022

CCID

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Purpose Central centrifugal cicatricial alopecia (CCCA) is the most common cause of scarring alopecia in women of African descent. However, current treatments for CCCA, such as immunosuppressants and immunomodulatory pharmaceutical agents, have suboptimal efficacy and undesirable side effects. This case series reports the therapeutic effect of a new botanical formulation (Dr. UGro Gashee) in four patients with histologically supported diagnoses of CCCA. The formulations contain at least three phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events contributing to CCCA. Possible mechanisms of action include anti-inflammatory effects, inhibiting proinflammatory cytokines, and the net antifibrotic effect of inhibiting transforming growth factor-beta while upregulating AMP-activated protein kinase and peroxisome proliferator-associated receptor-gamma activity. Patients and Methods Four African American women with treatment-refractory CCCA were treated with a new topical botanical formula (cosmeceutical) alone or in combination with its oral formulation (nutraceutical) for 8 weeks to 1 year. The cosmeceutical and nutraceutical treatments contain similar phytoactive ingredient profiles. Treatment outcomes were collected using documented patient reports and images and by direct observation. Results In all patients, scalp pruritus cessation occurred within 2 weeks of treatment, and significant hair regrowth was observed within 2 months. All patients reported a high satisfaction level without adverse effects. Conclusion Patients with treatment-refractory CCCA responded to the novel botanical treatment reported in this study. Further evaluations in a controlled trial with more patients are warranted.

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Section: Introductionmentioning

confidence: 99%

Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

Umar¹,

Kan²,

Carter³

et al. 2022

CCID

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“…Treatment for early TA may include intralesional corticosteroids, antibiotics, and topical minoxidil ( Khumalo and Ngwanya, 2007c , Uwakwe et al, 2020 ). Hair transplantation has been shown to be effective for late TA with permanent alopecia ( Earles, 1986 , Okereke et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The art of prevention: It’s too tight—Loosen up and let your hair down

Mayo

Callender

2021

International Journal of Women's Dermatology

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Traction alopecia is prevalent in patients of color. Its significance in clinical practice may be underemphasized due to the transient nature of the condition; however, it has the potential to become permanent and cause significant psychosocial distress. Understanding of afro-textured hair and cultural practices, as well as early recognition and treatment, provides an opportunity to prevent permanent traction alopecia and long-term sequelae.

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“…Despite that FPHL peaks up after puberty, it can still appear in younger ages. It involves the vertex, upper parietal scalp, and the fronto‐parietal areas with a characteristic preservation of the frontal hairline and less miniaturization in comparison with male pattern hair loss (MPHL) 2 …”

Section: Introductionmentioning

confidence: 99%

Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial

Ibrahim

Hasan

Elsabaa

et al. 2021

J of Cosmetic Dermatology

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Background Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance. Aim The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam. Methods Patients with FPHL were randomly assigned to pumpkin seed oil (n = 30; group A) or minoxidil 5% foam (n = 30; group B) for a period of 3 months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3‐month study. Results Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5 ± 6.2%, 24.0 ± 4.02, P < .001, respectively) as well as in the vellus hairs (22.5 ± 4.9, 15.8 ± 2.2, P < .001, respectively). Upright regrowing hairs significantly increased from (0.13 ± 0.5) before treatment to (0.9 ± 1.0) after treatment (P < .001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5 ± 6.3%, 21.3 ± 2.2, P < .001, respectively) as well as in the vellus hairs (24.7 ± 6.4, 19.5 ± 5.4, P = .02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.

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Current and emerging treatment strategies for hair loss in women of color

Cited by 23 publications

References 55 publications

Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment

The art of prevention: It’s too tight—Loosen up and let your hair down

Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial

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