Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review

Zou, Xinda; Bk, Amrit; Abu-Izneid, Tareq; Aziz, Ahsan; Devnath, Popy; Rauf, Abdur; Mitra, Saikat; Emran, Talha Bin; Mujawah, Adil A. H.; Lorenzo, José M.; Mubarak, Mohammad S.; Wilairatana, Polrat; Suleria, Hafiz Ansar Rasul

doi:10.1016/j.biopha.2021.112191

Cited by 42 publications

(28 citation statements)

References 108 publications

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“…According to recent reports, the global tobacco annual production in 2020 was 5.88 million metric tons [ 2 ], and this led to trillions of waste materials each year [ 5 ] with follow-up negative effects on the environment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Better yields and good quality products ensue thanks to this practice at the end of the harvest. Moreover, during the handling in the field, some broken leaves are discarded (scrap), while the midribs, as well as the smallest pieces of tobacco waste, which do not serve any purpose (dust or offal), are removed during the manufacturing of cigarettes [ 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Nicotiana tabacum Leaf Waste: Morphological Characterization and Chemical-Functional Analysis of Extracts Obtained from Powder Leaves by Using Green Solvents

et al. 2023

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Tobacco cultivation and industrialization are characterized by the production of trillions of pre-harvest and post-harvest waste biomasses each year with the resulting negative effects on the environment. The leaves of blunt, pre-harvest waste, could be further used to obtain bioactive metabolites, i.e., polyphenols and alkaloids, for its potential cosmetic use. This study was conducted to obtain bio-compounds from pre-harvest tobacco leaf waste (var. Virginia) by applying conventional and green solvents (NaDES). Leaves and ground leaf waste were characterized based on their microscopic features. Conventional solvents, such as water, acetone, ethanol, and non-conventional solvents, such as Natural Deep Eutectic Solvents (NaDES), i.e., sucrose:lactic acid (LAS), frutose:glucose:sucrose (FGS), lactic acid:sucrose:water (SALA), choline chloride:urea (CU), and citric acid: propylene glycol (CAP) were used for bioactive extraction from tobacco waste powder. CU, FGS, and acetone/ethanol had similar behavior for the best extraction of alkaloids (6.37–11.23 mg ACE/g tobacco powder). LAS, FGS, SALA, and CU were more effective in phenolic compound extraction than conventional solvents (18.13–21.98 mg AGE/g tobacco powder). Because of this, LAS and SALA could be used to obtain phenolic-enriched extracts with lower alkaloid content rather than CU and FGS. Extracts of the powder obtained with conventional solvent or CU showed a high level of sugars (47 mg/g tobacco powder) The ABTS antioxidant capacity of tobacco leaf powder was higher in the extracts obtained with CU, FGS, and acetone (SC50 1.6–5 µg GAE/mL) while H2O2 scavenging activity was better in the extracts obtained with LAS, CAP and SALA (SC50 3.8–8.7 µg GAE/mL). Due to the biocompatibility of the NaDES with the components of tobacco leaf waste, the opportunity to apply these extracts directly in antioxidant formulations, such as cosmetics, phytotherapic, and other formulations of topic use seems promising. Furthermore, NaDES constituents, i.e., urea and organic acid can also have beneficial effects on the skin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nicotiana tabacum Leaf Waste: Morphological Characterization and Chemical-Functional Analysis of Extracts Obtained from Powder Leaves by Using Green Solvents

et al. 2023

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“…Perlakuan 12 jam berbeda nyata dengan perlakuan 24, 36, 48 dan 60 jam. Perendaman 60 jam dengan intensitas serangan 22,06% tergolong dalam intensitas serangan yang ringan (Zou et al, 2021). Perlakuan (24-60) jam tergolong intensitas serangan sedang karena intensitasnya 25%-50% dan pada perendaman 12 jam dengan intensitas serangan 52,96% tergolong intensitas serangan berat (Isman et al, 2001).…”

Section: Hasil Dan Pembahasanunclassified

Respons Ulatgrayak (Spodoptera litura) Terhadap Lama Perendaman Tembakau Rajang (Nicotiana tabacum L.) Sebagai Insektisida Nabati

Silalahi

2021

Agrosains: J. Penelit. Agron.

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Tembakau merupakan tanaman yang mementingkan kualitas daunnya, kerusakan pada daun tembakau dapat mengurangi nilai jualnya. Ulatgrayak (Spodoptera litura) merupakan hama di tanaman tembakau yang merusak daun tanaman tembakau. . Ekstraksi dari bagian tanaman tembakau dapat dijadikan sebagai bahan baku pestisida nabati, tembakau rajang yang diekstrak dapat menghasilkan kandungan alkaloid yang dapat digunakan sebagai insektisida untuk mengendalikan ulat grayak. Tujuan penelitian ini adalah untuk mendapatkan lama perendaman tembakau rajang yang terbaik untuk mengendalikan ulatgrayak. Penelitian dilakukan di laboratorium dan di lahan yang menggunakan tanaman tembakau sebagai inang larva ulatgrayak instar III dengan cara kerja racun kontak. Metoda penelitian menggunakan Rancangan Acak Kelompok (RAK) dengan perlakuan lama perendaman tembakau rajang 12, 24, 36, 48 dan 62 jam dengan lima ulangan. Variabel yang diamati adalah mortalitas, intensitas serangan dan lama pembentukan pupa. Hasil penelitian menunjukkan bahwa rendaman tembakau rajang efektif terhadap mortaitas uatgrayak, lama perendaman tembakau rajang juga dapat mempercepat pembentukan pupa dan perendaman 60 jam memiliki intensitas serangan terbaik.

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“…Although cigarettes have adverse e ects on humans and the environment, N. tabacum contains several useful phytochemical components that could be applied in other industries. N. tabacum has been reported to contain large numbers of secondary metabolites exerting many biological and pharmacological activities [1,2]. For example, previous research found that alkaloids derived from plant extracts had an antiinsect e ect, which is important in agriculture, as well as exerting health bene ts for Alzheimer's and Parkinson's diseases [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical, Antioxidant, Antihyaluronidase, Antityrosinase, and Antimicrobial Properties of Nicotiana tabacum L. Leaf Extracts

Prommaban

Kheawfu

Chittasupho

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Nicotiana tabacum L. (tobacco) is an important and valuable crop for the cigarette industry. However, cigarette cessation has been encouraged worldwide. Therefore, this study aimed to investigate the potential of N. tabacum leaf extract use in other industries besides cigarette production, especially cosmeceutical industries, which are of interest for increasing the value and widening the applications of N. tabacum. The leaves of N. tabacum var. Virginia and Turkish were extracted by maceration using 95% v/v ethanol or petroleum ether. The extracts were evaluated for their phytochemical compositions, antioxidant capacity, and anti-aging, antimelanogenic, and antimicrobial activities. The phytochemical screening of the extracts revealed terpenoids, steroids, alkaloids, tannins, and carbohydrates in all of the N. tabacum leaf extracts. The total phenolic content was detected to be the highest in the ethanolic extract of Virginia tobacco leaf, which had the most significantly potent antioxidant and antihyaluronidase activity ( P < 0.05 ). On the contrary, the extracts from the Turkish variety demonstrated the most powerful antimicrobial activity against Staphylococcus aureus. Thus, ethanolic extracts of N. tabacum var. Virginia are suggested as good natural anti-aging ingredients with potent antioxidant and antihyaluronidase effects, whereas the leaf of N. tabacum var. Turkish is suggested as a good source of natural antimicrobial components, particularly for S. aureus inhibition. In summary, in addition to the cigarette industry, N. tabacum leaf could be a source of pharmaceutical and cosmeceutical compounds, particularly natural anti-aging and antimicrobial ingredients.

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Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review

Cited by 42 publications

References 108 publications

Nicotiana tabacum Leaf Waste: Morphological Characterization and Chemical-Functional Analysis of Extracts Obtained from Powder Leaves by Using Green Solvents

Nicotiana tabacum Leaf Waste: Morphological Characterization and Chemical-Functional Analysis of Extracts Obtained from Powder Leaves by Using Green Solvents

Respons Ulatgrayak (Spodoptera litura) Terhadap Lama Perendaman Tembakau Rajang (Nicotiana tabacum L.) Sebagai Insektisida Nabati

Phytochemical, Antioxidant, Antihyaluronidase, Antityrosinase, and Antimicrobial Properties of Nicotiana tabacum L. Leaf Extracts

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