Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives

Su, Chunhong; Ren, Xiaojun; Nie, Fang; Li, Tiangang; Lv, Wenhao; Li, Hui; Zhang, Yao

doi:10.1039/d0ra08727k

Cited by 49 publications

(34 citation statements)

References 119 publications

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“…The second effect is cavitation. Cavitation is characterized by repetitive, yet non-destructive oscillation of micro/nanobubbles which results in enhancing the blood vessels permeability to micro/nanobubbles [ 192 ]. Employing ultrasound field also results in the induction of hyperthermia in the target tissue [ 193 ].…”

Section: Enhancing Hcc Uptakementioning

confidence: 99%

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

et al. 2022

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Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Multiple conventional approaches are being used in treating hepatocellular carcinoma. Focusing on drug treatment, regular agents in conventional forms fail to achieve the intended clinical outcomes. In order to improve the treatment outcomes, utilizing nanoparticles—specifically lipid based nanoparticles—are considered to be one of the most promising approaches being set in motion. Multiple forms of lipid based nanoparticles exist including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, phytosomes, lipid coated nanoparticles, and nanoassemblies. Multiple approaches are used to enhance the tumor uptake as well tumor specificity such as intratumoral injection, passive targeting, active targeting, and stimuli responsive nanoparticles. In this review, the effect of utilizing lipidic nanoparticles is being discussed as well as the different tumor uptake enhancement techniques used. Graphical Abstract

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Section: Enhancing Hcc Uptakementioning

confidence: 99%

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

et al. 2022

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“…15 Alongside, US has been used therapeutically since the beginning of the 20th century, offering many advantages, such as ease of application and spatiotemporal control. [16][17][18] Medical US is classied into three categories based on frequency and applications: low frequency US describes sound waves below 1 MHz, which can be used for sonophoresis, transdermal permeability enhancements, sonobactericide, and tissue ablation. 19,20 Application safety increases with frequency because of the diminished damage to and overheating of tissues.…”

Section: Introductionmentioning

confidence: 99%

Sonopharmacology: controlling pharmacotherapy and diagnosis by ultrasound-induced polymer mechanochemistry

2022

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“…In this context, polymer-shelled nanobubbles (NBs) have shown great potential as a nanoplatform for efficient nucleic acid delivery [37][38][39][40][41]. Interestingly, they can be combined with an ultrasound (US) to improve the delivery of active molecules [42]. Therefore, US-triggered gene delivery with NBs can be advantageous, since the release of their payload can be obtained in specific sites in response to US application [43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

et al. 2022

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The siRNA-mediated inhibition of nuclear factor E2-related factor 2 (Nrf2) can be an attractive approach to overcome chemoresistance in various malignant tumors, including melanoma. This work aims at designing a new type of chitosan-shelled nanobubble for the delivery of siRNA against Nrf2 in combination with an ultrasound. A new preparation method based on a water–oil–water (W/O/W) double-emulsion was purposely developed for siRNA encapsulation in aqueous droplets within a nanobubble core. Stable, very small NB formulations were obtained, with sizes of about 100 nm and a positive surface charge. siRNA was efficiently loaded in NBs, reaching an encapsulation efficiency of about 90%. siNrf2-NBs downregulated the target gene in M14 cells, sensitizing the resistant melanoma cells to the cisplatin treatment. The combination with US favored NB cell uptake and transfection efficiency. Based on the results, nanobubbles have shown to be a promising US responsive tool for siRNA delivery, able to overcome chemoresistance in melanoma cancer cells.

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Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives

Abstract: NBs combined with ultrasound demonstrated the ability to enhance the targeting of anticancer agents and improve the efficacy.

Cited by 49 publications

References 119 publications

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

Sonopharmacology: controlling pharmacotherapy and diagnosis by ultrasound-induced polymer mechanochemistry

Ultrasound-Responsive Nrf2-Targeting siRNA-Loaded Nanobubbles for Enhancing the Treatment of Melanoma

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