Current Advances in the Studies of Oxidative Stress and Age‐Related Memory Impairment in<i>C. elegans</i>

Murakami, Shin; Cabana, Kelly; Anderson, Danielle E.

doi:10.1002/9781118148143.ch25

Cited by 12 publications

(17 citation statements)

References 115 publications

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“…In contrast, ACE as an amyloid-degrading enzyme has been used to control more advanced phase accumulation of beta-amyloid. The different activities of ACE support the notion of aging stages from the transition state to the more advanced pathological state [68][69][70]. Furthermore, those are consistent with a previous study that indicates the underlying mechanisms of the human AD genes, including lipid metabolism, amyloid-related pathways, and neural and immune systems [10].…”

Section: Ace As a Link To Aging (Life Extension Model Systems)supporting

confidence: 90%

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Brown

Malik

et al. 2021

IJMS

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A 2018 report from the American Heart Association shows that over 103 million American adults have hypertension. The angiotensin-converting enzyme (ACE) (EC 3.4.15.1) is a dipeptidyl carboxylase that, when inhibited, can reduce blood pressure through the renin–angiotensin system. ACE inhibitors are used as a first-line medication to be prescribed to treat hypertension, chronic kidney disease, and heart failure, among others. It has been suggested that ACE inhibitors can alleviate the symptoms in mouse models. Despite the benefits of ACE inhibitors, previous studies also have suggested that genetic variants of the ACE gene are risk factors for Alzheimer’s disease (AD) and other neurological diseases, while other variants are associated with reduced risk of AD. In mice, ACE overexpression in the brain reduces symptoms of the AD model systems. Thus, we find two opposing effects of ACE on health. To clarify the effects, we dissect the functions of ACE as follows: (1) angiotensin-converting enzyme that hydrolyzes angiotensin I to make angiotensin II in the renin–angiotensin system; (2) amyloid-degrading enzyme that hydrolyzes beta-amyloid, reducing amyloid toxicity. The efficacy of the ACE inhibitors is well established in humans, while the knowledge specific to AD remains to be open for further research. We provide an overview of ACE and inhibitors that link a wide variety of age-related comorbidities from hypertension to AD to aging. ACE also serves as an example of the middle-life crisis theory that assumes deleterious events during midlife, leading to age-related later events.

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Section: Ace As a Link To Aging (Life Extension Model Systems)supporting

confidence: 90%

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Brown

Malik

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast, ACE as an amyloid-degrading enzyme is to control more advanced phase, accumulation of beta-amyloid. The different activities of ACE support the notion of aging stages from transition state to more advanced pathological state[62][63][64]. Furthermore, those are consistent with the previous study that indicates the underlying mechanisms of the human…”

supporting

confidence: 90%

“…ACE provides an example for the middle-life crisis theory on aging describes middle life events which cause aging and age-related diseases in late life, which explain the transition to aging from normal to more advanced age-related changes [63,64].…”

Section: Ace As a Link To Aging (Life Extension-model Systems)mentioning

confidence: 99%

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Le¹,

Brown²,

Malik³

et al. 2021

Preprint

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A recent report from the American Heart Association in 2018 shows that over 103 million American adults have hypertension. The angiotensin-converting enzyme (ACE) (EC 3.4.15.1) is a dipeptidyl carboxylase that, when inhibited, can reduce blood pressure through the renin-angiotensin system. ACE inhibitors are used as a first-line medication to be prescribed to treat hypertension, chronic kidney disease, heart failure among others. It has been suggested that ACE inhibitors can reduce the symptoms in mouse models. Despite the benefits of ACE inhibitors, previous studies also have suggested that alterations in the ACE gene are risk factors for Alzheimer’s disease (AD) and other neurological diseases. In mice, overexpression of ACE in the brain reduces symptoms of the AD-model systems. Thus, we find opposing effects of ACE on health. To clarify the effects, we dissect the functions of ACE as follows: (1) angiotensin-converting enzyme that hydrolyzes angiotensin I to make angiotensin II in the renin-angiotensin system; (2) amyloid-degrading enzyme that can hydrolyze beta-amyloid and reduce amyloid toxicity. The efficacy of the ACE inhibitors is well established in humans, while the knowledge specific to AD remains to be open for further research. We provide an overview of ACE and inhibitors that link a wide variety of age-related comorbidities from hypertension to Alzheimer’s disease to aging. ACE also serves as an example of the middle-life crisis theory that assumes deleterious events during the midlife, leading to age-related later events.

show abstract

“…Such feedback emphasizes the importance of existing comorbidities and potential interaction/association between co-occurring diseases. This approach is consistent with the “mid-life crisis theory,” in which earlier deleterious events are associated with aging and later age-related diseases (Murakami et al, 2011 ; Murakami, 2013 ).…”

supporting

confidence: 82%

Editorial: Biology of Cognitive Aging: Model Systems, Technologies, and Beyond

Murakami

2016

Front. Genet.

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Current Advances in the Studies of Oxidative Stress and Age‐Related Memory Impairment inC. elegans

Cited by 12 publications

References 115 publications

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Editorial: Biology of Cognitive Aging: Model Systems, Technologies, and Beyond

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