Current Advancement on the Dynamic Mechanism of Gastroesophageal Reflux Disease

Abstract

Gastroesophageal reflux disease (GERD) is a common clinical disease associated with upper gastrointestinal motility disorders. Recently, with improvements in living standards and changes in lifestyle and dietary habits, the incidence of GERD has been increasing yearly. However, the mechanism of GERD has not been fully elucidated due to its complex pathogenesis, and this had led to unsatisfactory therapeutic outcomes. Currently, the occurrence and development of GERD involve multiple factors. Its pathogenesis is mainly thought to be related to factors, such as lower esophageal sphincter pressure, transient lower esophageal sphincter relaxation, crural diaphragmatic dysfunction, hiatus hernia, and impaired esophageal clearance. Therefore, explaining the pathogenesis of GERD more clearly and systematically, exploring potential and effective therapeutic targets, and choosing the best treatment methods have gradually become the focus of scholars' attention. Herein, we reviewed current advancements in the dynamic mechanism of GERD to better counsel patients on possible treatment options.

Enfermedad por reflujo gastroesofágico

“…Cierto grado de reflujo gastroesofágico es fisiológico y no suele generar síntomas, y de generarlos suelen ser leves, autolimitados y no alteran la calidad de vida ni generan complicaciones (1,5).…”

“…ISSN: 0120-5498 • Med. 44 (3) 328-337 • Julio -Septiembre 2022 (4)(5)(6)(7). Para Suramérica se estima una incidencia de síntomas de 17,6 % y para nuestro país una prevalencia alrededor del 13 % (1,8).…”

Treatment of the Gastroesophageal Reflux Disease with Chinese Herbal Medicine (BanxiaXiexin Decoction): Evidence from Meta-Analysis

“…The pathogenesis of GERD has not been fully elucidated. According to available evidence, the development of GERD involves a variety of potential mechanisms, such as transient lower esophageal sphincter relaxation, lower esophageal sphincter pressure, hiatus hernia, crural diaphragmatic dysfunction, and impaired esophageal clearance [ 7 ]. Pharmacological experiments have verified the effectiveness of Banxia Xiexin decoction (BXD) in the treatment of GERD [ 8 ].…”

Phenotypes of gastroesophageal reflux disease: classification, pathogenesis and diagnostic criteria: A review

“…В настоящее время отмечается высокая распространенность данного симптома среди пациентов терапевтического и гастроэнтерологического профиля с тенденцией к неуклонному росту (рис. 1) [2,3]. Среди городских жителей России, обратившихся за первичной медицинской помощью, изжога отмечается у 59,5% пациентов, при этом 22,7% испытывают изжогу 2 раза в неделю, а у мужчин она возникает в большем проценте случаев, чем у женщин [4].…”