Curing Consortium Fatigue

Papadaki, M.; Hirsch, Gigi

doi:10.1126/scitranslmed.3006903

Cited by 32 publications

(25 citation statements)

References 8 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Knowledge and experience elicitation from experts within a field may include a variety of methods, including interviews, workshops, expert conversations, scenarios, and decision-making tools [26,27]. Thus, to iteratively develop the roadmap, we adopted a hybrid of such methods, including Expert Reference Groups for consensus and decision making, a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis, a research theme prioritization exercise (based on a modified version of the WHO's 2016 prioritization exercise [15]), and 1:1 consultations with professional and lay expert stakeholders and key opinion leaders (KOLs).…”

Section: Methodsmentioning

confidence: 99%

A roadmap to develop dementia research capacity and capability in Pakistan: A model for low‐ and middle‐income countries

Leroi

Chaudhry

Daniel³

et al. 2019

A&D Transl Res & Clin Interv

View full text Add to dashboard Cite

ObjectiveTo produce a strategic roadmap for supporting the development of dementia research in Pakistan.BackgroundWhile global research strategies for dementia research already exist, none is tailored to the specific needs and challenges of low- and middle-income countries (LMIC) like Pakistan.MethodsWe undertook an iterative consensus process with lay and professional experts to develop a Theory of Change-based strategy for dementia research in Pakistan. This included Expert Reference Groups (ERGs), strategic planning techniques, a “research question” priority survey, and consultations with Key Opinion Leaders.ResultsWe agreed on ten principles to guide dementia research in Pakistan, emphasizing pragmatic, resource sparing, real-world approaches to support people with dementia, both locally and internationally. Goals included capacity/capability building. Priority research topics included raising awareness and understanding of dementia, and improving quality of life.ConclusionThis roadmap may be a model for other LMIC health ecosystems with emerging dementia research cultures.

show abstract

Section: Methodsmentioning

confidence: 99%

A roadmap to develop dementia research capacity and capability in Pakistan: A model for low‐ and middle‐income countries

Leroi

Chaudhry

Daniel³

et al. 2019

A&D Transl Res & Clin Interv

View full text Add to dashboard Cite

show abstract

“…This can lead to confusion and inefficiency. As is remarked succinctly in [51], 'we need an evidence-based approach -a science of collaboration -to evaluate and inform the evolving multi-stakeholder collaboration environment in biomedical innovation'.…”

Section: Consortiamentioning

confidence: 97%

“…Although, when viewed as an abstraction from organizations, perhaps unsurprisingly, the issue of 'consortium fatigue' [51] surfaces. Put simply, there is no agency tasked with coordinating consortia in a way that ensures optimal collaboration or use of resources across all consortia.…”

Section: Consortiamentioning

confidence: 99%

Crowdsourcing in pharma: a strategic framework

Bentzien¹,

Bharadwaj²,

Thompson³

2015

Drug Discovery Today

View full text Add to dashboard Cite

“…With more than 400 consortia estimated to operate globally (31), growth in the number of narrowly scoped collaborations has led to challenges in their coordination, oftentimes seen as duplication, fragmentation, and consortium fatigue (26). In addition, while many have successfully delivered their target outputs, defining their impact on the delivery of better treatments remains elusive, requiring the combination of outputs from different collaborations, each working on some aspect of the development and access pathway.…”

Section: Changing Course: Reinventing the Way We Develop Treatmentsmentioning

confidence: 99%

Adaptation through Collaboration: Developing Novel Platforms to Advance the Delivery of Advanced Therapies to Patients

Papadaki

2017

Front. Med.

Self Cite

View full text Add to dashboard Cite

For the nascent field of advanced therapies, collaboration will be a game-changer, turning scientific progress that was once unimaginable into transformative medical practice. Despite promise for lifelong management and even cure of disease, skepticism remains about the feasibility of their delivery to patients, fueling investment risks. With the potential for long-term effectiveness in need of frequent reassessment, current approaches to predict real-life drug performance bear little relevance, necessitating novel and iterative schemes to monitoring the benefit–risk profiles throughout the life span of advanced therapies. This work explains that reinventing an adoption route for Advanced Therapy Medicinal Products is as much about the scientific and clinical components, as it is about the organizational structures, requiring an unprecedented level of interactions between stakeholders not traditionally connected; from developers and regulators, to payers, patients, and funders. By reflecting on the successes and lessons learned from the growing space of global precompetitive consortia and public–private partnerships, as well as a number of emerging accelerated development pathways, this work aims to inform the foundations for a future roadmap that can smooth the path to approval, reimbursement, and access, while delivering value to all stakeholders. Echoing the growing demands to bring these transformative products to patients, it provides critical insights to enhance our capacity in three fundamental domains: deploying the operational flexibilities offered by the growing space of collaborations, utilizing emerging flexible and accelerated pathways to tackle challenges in quantifying long-term effectiveness, and building the necessary digital and clinical infrastructure for knowledge development.

show abstract

Curing Consortium Fatigue

Abstract: The complex pathology of consortium fatigue provides diagnostic data on how to improve collaboration in biomedical innovation.

Cited by 32 publications

References 8 publications

A roadmap to develop dementia research capacity and capability in Pakistan: A model for low‐ and middle‐income countries

A roadmap to develop dementia research capacity and capability in Pakistan: A model for low‐ and middle‐income countries

Crowdsourcing in pharma: a strategic framework

Adaptation through Collaboration: Developing Novel Platforms to Advance the Delivery of Advanced Therapies to Patients

Contact Info

Product

Resources

About