Cure prevents more than transmission of hepatitis C virus

Dahari, Harel; Cotler, S.J.; Feld, Mariana

doi:10.1002/hep.28449

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…In its phase one report, NAS determined that people at greatest risk for HCV are young PWID [49]. The recent availability of all oral direct-acting antivirals (DAAs) with high reported cure rates (e.g., >90% [50,51]) that can prevent liver disease progression and HCV transmission [52,53], combined with prevention and harm reduction strategies, make HCV elimination an attainable goal. However, barriers [50,[54][55][56][57][58][59][60], including the high cost of DAAs, poor linkage to care, low adherence to medication regimens, stigma, and possible reinfection, all warrant policy development and strategic planning to understand the factors that would most efficiently lead to HCV elimination among PWID.…”

Section: Discussionmentioning

confidence: 99%

High-Risk Geographic Mobility Patterns among Young Urban and Suburban Persons who Inject Drugs and their Injection Network Members

et al. 2017

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Young people in the USA who inject drugs, particularly those at a risk of residence instability, experience the highest incidence of hepatitis C (HCV) infections. This study examined associations between geographic mobility patterns and sociodemographic, behavioral, and social network characteristics of 164 young (ages 18-30) persons who inject drugs (PWID). We identified a potential bridge sub-population who reported residence in both urban and suburban areas in the past year (crossover transients) and higher-risk behaviors (receptive syringe sharing, multiple sex partners) compared to their residentially localized counterparts. Because they link suburban and urban networks, crossover transients may facilitate transmission of HIV and HCV between higher and lower prevalence areas. Interventions should address risk associated with residential instability, particularly among PWID who travel between urban and suburban areas.

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Section: Discussionmentioning

confidence: 99%

High-Risk Geographic Mobility Patterns among Young Urban and Suburban Persons who Inject Drugs and their Injection Network Members

et al. 2017

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“…Non-cirrhotic subjects successfully treated for HCV with achieved sustained virological response (SVR) were removed from the model. Subjects with cirrhosis remain in risk of liver complications in spite of SVR, and of those, 50% were retained in the model [ 28 ]. All successfully treated subjects with decompensated cirrhosis and HCC were kept in the model.…”

Section: Methodsmentioning

confidence: 99%

Future complications of chronic hepatitis C in a low-risk area: projections from the hepatitis c study in Northern Norway

et al. 2017

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BackgroundHepatitis C (HCV) infection causes an asymptomatic chronic hepatitis in most affected individuals, which often remains undetected until cirrhosis and cirrhosis-related complications occur. Screening of high-risk subjects in Northern Norway has revealed a relatively low prevalence in the general population (0.24%). Despite this, late complications of HCV infection are increasing. Our object was to estimate the future prevalence and complications of chronic HCV infection in the period 2013–2050 in a low-risk area.MethodsWe have entered available data into a prognostic Markov model to project future complications to HCV infection.ResultsThe model extrapolates the prevalence in the present cohort of HCV-infected individuals, and assumes a stable low incidence in the projection period. We predict an almost three-fold increase in the incidence of cirrhosis (68 per 100,000), of decompensated cirrhosis (21 per 100,000) and of hepatocellular carcinoma (4 per 100,000) by 2050, as well as a six-fold increase in the cumulated number of deaths from HCV-related liver disease (170 per 100,000 inhabitants). All estimates are made assuming an unchanged treatment coverage of approximately 15%. The estimated numbers can be reduced by approximately 50% for cirrhosis, and by approximately one third for the other endpoints if treatment coverage is raised to 50%.ConclusionThese projections from a low-prevalence area indicate a substantial rise in HCV-related morbidity and mortality in the coming years. The global HCV epidemic is of great concern and increased treatment coverage is necessary to reduce the burden of the disease.Electronic supplementary materialThe online version of this article (10.1186/s12879-017-2722-0) contains supplementary material, which is available to authorized users.

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Cure prevents more than transmission of hepatitis C virus

Cited by 2 publications

References 3 publications

High-Risk Geographic Mobility Patterns among Young Urban and Suburban Persons who Inject Drugs and their Injection Network Members

High-Risk Geographic Mobility Patterns among Young Urban and Suburban Persons who Inject Drugs and their Injection Network Members

Future complications of chronic hepatitis C in a low-risk area: projections from the hepatitis c study in Northern Norway

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