Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model

Tai, Y. I.; Lin, Ying; Wang, Kai-Chen; Chang, Chuang–Rung; Chen, Ruyin; Wu, Chang-Mou; Cheng, Irene H.

doi:10.18632/oncotarget.24369

Cited by 22 publications

(24 citation statements)

References 52 publications

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“…Curcumin was purchased from the National Institute for the Control of Pharmaceutical and Biological products (Beijing, China), dissolved in polyethylene glycol (PEG <10%) and put in 4°C (Tai et al, 2018).…”

Section: Drug Preparationmentioning

confidence: 99%

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Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Li¹,

Han²,

et al. 2019

Cellular Reprogramming

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The abnormal deposition of amyloid-b peptide, a major component of senile plaques, has been reported to be the major cause of neuronal cell death and cognitive impairment in Alzheimer's disease (AD). Adult neurogenesis is related to the amelioration of impaired neurons and cognitive impairment. In the research, we investigated the function of curcumin on endogenous neural stem cells (NSCs) and hippocampal neurogenesis in mice. APP/PS1 transgenic mice as animal models were treated with curcumin, and a significant improvement in learning and memory function was observed. The improvement was associated with a significant increase in the number of new neural stem cells (BrdU + /Nestin +) and newborn neurons (NeuN/kI67 +) in the hippocampal region and decreased the number of apoptotic neurons (TUNEL + and Caspase-3/NeuN +). These results suggested that curcumin activated NSCs proliferation, improved neurogenesis, and ameliorated cognitive impairment of AD mice. Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein. As Notch activity was blocked by the DAPT, the related proteins were downregulated, and the initiating cell proliferation of curcumin was abolished. These results might suggest that the function of curcumin was dependent on Notch signaling pathway.

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Section: Drug Preparationmentioning

confidence: 99%

“…WT C57BL/6 mice in WT group were given no treatment (n = 20 for each group). All experimental protocols were approved by Institutional Animal Care and Use Committee ( Jiao et al, 2016;Tai et al, 2018).…”

Section: Drug Preparationmentioning

confidence: 99%

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Li¹,

Han²,

et al. 2019

Cellular Reprogramming

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“…Ng et al, ). Similarly, many studies have found curcumin treatment to reduce amyloid deposition and improve cognitive performance in Alzheimer's disease (AD) animal models (Bassani et al, ; McClure et al, ; Tai et al, ). Animal studies have lent support to the hypothesis that curcumin could improve cognitive functioning and enhance cell proliferation of dentate gyrus in aged animals (Conboy et al, ).…”

Section: Introductionmentioning

confidence: 99%

Curcumin intervention for cognitive function in different types of people: A systematic review and meta‐analysis

Zhu

Mei

Zeng-guo

et al. 2018

Phytotherapy Research

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Curcumin is a polyphenolic natural compound with diverse and attractive biological activities, which may prevent or ameliorate pathological processes underlying age‐related cognitive decline, dementia, or mood disorders. However, clinical trials and animal studies have yielded conflicting conclusions regarding its effectiveness for cognition in different individuals. The aim of this review is to meta‐analytically assess the effectiveness of curcumin for cognitive function in different types of people. A preliminary search on PubMed, Embase, Web of Science, ClinicalTrials.gov, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang Data and China Biology Medicine disc was performed to identify randomized controlled trials investigating the effect of curcumin on cognition. Six clinical trials with a total of 289 subjects met inclusion criteria for this review. We used a random‐effects model to calculate the pooled standardized difference of means (SMD). For older adults who received curcumin, scores on measures of cognitive function (SMD = 0.33, 95% confidence interval [CI] [0.05, 0.62]; p = 0.02), occurrence of adverse events (odds ratio [OR] = 5.59, 95% CI [0.96, 36.80]; p = 0.05), and measures of depression (SMD = −0.29, 95% CI [0.64, 0.05]; p = 0.09) indicated significant memory improvement. In patients with Alzheimer's disease (AD), scores in measures of cognition status (SMD = −0.90, 95% CI [1.48, −0.32]; p = 0.002) indicated that there was a trend for treated subjects to do worse than placebo‐treated subjects on the Mini‐Mental State Examination. The occurrence of adverse events (OR = 0.87, 95% CI [0.10, 7.51]; p = 0.90) was similar to those who received placebo. Due to insufficient data, it was impossible to provide a narrative account of only the outcomes for schizophrenia. Curcumin appears to be more effective in improving cognitive function in the elderly than in improving symptoms of AD and schizophrenia. Curcumin is also safe and tolerated among these individuals. Because of the small number of studies available, a funnel plot or sensitivity analysis was not possible. Further high‐quality trials with larger sample sizes or bioavailability‐improved curcumin formulations may be considered for reliable assessment.

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“…Curcumin can upregulate the critical molecule, PI3K/AKT, and the insulin signaling pathway to reduce insulin resistance in APP/PS1 mice (Feng et al, ). In another study, curcumin treatment significantly ameliorated the cognitive function of APP mice by reducing amyloid deposition and astroglosis (Tai et al, ). In summary, curcumin exhibits its protective efficacy through multiple mechanisms.…”

Section: Discussionmentioning

confidence: 96%

Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

Sun

Liu

et al. 2018

The Anatomical Record

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Curcumin is a natural product with several anti-Alzheimer's disease (AD) neuroprotective properties. This study aimed to investigate the effects of curcumin on memory deficits, lactate content, and monocarboxylate transporter 2 (MCT2) in APP/PS1 mouse model of AD. APP/PS1 transgenic mice and wild-type (WT) C57BL/6J mice were used in the present study. Spatial learning and memory of the mice was detected using Morris water-maze test. Cerebral cortex and hippocampus lactate contents were detected using lactate assay. MCT2 expression in the cerebral cortex and hippocampus was examined by immunohistochemistry and Western blotting. Results showed that spatial learning and memory deficits were improved in curcumintreated APP/PS1 mouse group compared with those in APP/PS1 mice group. Brain lactate content and MCT2 protein level were increased in curcumintreated APP/PS1 mice than in APP/PS1 mice. In summary, our findings indicate that curcumin could ameliorate memory impairments in APP/PS1 mouse model of AD. This phenomenon may be at least partially due to its improving effect on the lactate content and MCT2 protein expression in the brain. Anat Rec, 302:332-338, 2019. Alzheimer's disease (AD) is the most common neurodegenerative disease that affects aged people (Adav and Sze, 2016). Patients with AD exhibit progressive behavioral impairments, including memory loss, cognitive decline, and personality changes. Emerging evidence suggests that decreased energy metabolism is an important

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Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer’s disease mouse model

Cited by 22 publications

References 52 publications

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Curcumin intervention for cognitive function in different types of people: A systematic review and meta‐analysis

Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

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