Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis

Goulart, Ricardo de Álvares; Barbalho, Sandra Maria; Rubira, Cláudio José; Araújo, Adriano Cressoni; Lima, Vinícius Marinho; Buchaim, Rogério Leone; Guiguer, Élen Landgraf

doi:10.1080/17474124.2020.1808460

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…Nevertheless, some adverse effects are related to its consumption, such as dyspepsia, nausea, flatulence, and diarrhea. It was also demonstrated that turmeric could interact with some medications; it affects cytochromes P450, and the pharmacokinetics of some conventional drugs such as anticoagulants, antibiotics, antidiabetics, cardiovascular drugs, anticancer drugs, and antidepressants are influenced by curcuminoids (52,(80)(81)(82).…”

Section: Curcuma Longamentioning

confidence: 99%

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

et al. 2021

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Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.

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Section: Curcuma Longamentioning

confidence: 99%

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

et al. 2021

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“…SRs/MAs. Seven SRs/MAs [20][21][22][23][24][25][26] published from 2018 to 2021 were included. Of these published SRs/MAs, two are from China [25,26], two from the United States [20,23], and the remaining three from Brazil [22], Iran [21], and Greece [24].…”

Section: Description Of Includedmentioning

confidence: 99%

Quality of Evidence Supporting the Role of Supplement Curcumin for the Treatment of Ulcerative Colitis: An Overview of Systematic Reviews

Shi

Wang

Chen

et al. 2022

Gastroenterology Research and Practice

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Objectives. Curcumin is a potential complementary treatment for ulcerative colitis (UC). This overview systematically summarizes and evaluates the existing evidence of curcumin in the treatment of UC. Methods. Two researchers searched seven databases for systematic reviews (SRs)/meta-analyses (MAs) which are about randomized controlled trials (RCTs) on curcumin for UC. Two researchers use the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Risk of Bias in Systematic Reviews (ROBIS) scale, the list of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the included SRs/MAs. Results. Seven published SRs/MAs were included in our study. According to the results of the AMSTAR-2 assessment, all SRs/MAs are considered to be of very low quality. According to the ROBIS evaluation results, no SR/MA has been assessed as a low risk of bias. According to the results of the PRISMA checklist assessment, no SR/MA has been fully reported on the PRISMA checklist. According to GRADE, a total of 19 outcome indicators extracted from the included SRs/MAs were evaluated. The quality of evidence was 10 moderate, 6 low, and 3 very low. Conclusions. Curcumin may be an effective and safe complementary treatment for UC. However, further standard and comprehensive SRs/MAs and RCTs are needed to provide an evidence-based medical rationale for this.

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“…The Th9 cells also participate in IBD pathology, characterized by the production of IL-9 and induced by IL-4 and TGF-β, causing a block in the proliferation of intestinal epithelial cells and downregulating the expression of tight-junction proteins, including claudin and occludin. Lastly, Treg is a CD4 T-cell suppressor by secreting anti-inflammatory cytokines, such as IL-10 and TGF-β, inhibiting Dendritic cells and macrophages [11,[13][14][15].…”

Section: Pathophysiological Mechanisms Of Ibdmentioning

confidence: 99%

Effects of probiotics on inflammatory bowel disease: A systematic review

Lopes¹,

Campanari²,

Barbalho³

et al. 2021

Japanese J Gastroenterol Res

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Inflammatory Bowel Disease (IBD) is a chronic idiopathic inflammation of the gastrointestinal tract, characterized by periods of exacerbation and remission, which includes two primary forms: Ulcerative Colitis (UC) and Crohn's Disease (CD). IBD is an autoimmune disorder influenced by genetics, hereditary, environment, and infection. Alternative treatments with fewer side effects have been searched. Thus, the use of probiotics stands out due to several beneficial effects. For this reason, the objective of this systematic review is to evaluate the effects of the use of probiotics in patients diagnosed with IBD. This review included studies available in the MEDLINE databases - PubMed, EMBASE, and Cochrane, and the final selection included thirteen randomized clinical trials. The results showed that the oral use of probiotics and, mainly for a prolonged period, can help in the improvement of reducing symptoms related to IBD. In endoscopic analyzes, a reduction in intestinal inflammation was noted, in addition to a reduction in proinflammatory cytokines. Although there are positive effects, there is a need for further studies to define the best composition of probiotics and time of use since there are many variations in this treatment.

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Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis

Cited by 14 publications

References 31 publications

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

Quality of Evidence Supporting the Role of Supplement Curcumin for the Treatment of Ulcerative Colitis: An Overview of Systematic Reviews

Effects of probiotics on inflammatory bowel disease: A systematic review

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