Curcumin supplement diet: Enhanced growth and down‐regulated expression of pro‐inflammatory cytokines in
            <i>Labeo rohita</i>
            fingerlings

Leya, Tasok; Dar, Showkat Ahmad; Kumar, Gagan; Ahmad, Irshad

doi:10.1111/are.14825

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…Few studies also worked towards the investigation of induction of proand anti-inflammatory cytokine gene expression levels. 147,149,161,162 Other studies documented an influence on the specific immune system marked by the enhanced production of immunoglobulins, particularly IgM, in L. rohita. 144,150,159 Further, these additives were discovered to provoke components of the innate immune system in skin and mucosa, in response to pathogenic infection in L. rohita.…”

Section: Phytobioticsmentioning

confidence: 99%

“…In addition, few studies have also worked with isolated phytochemicals like andrographolide, 158 emodin, 159 piperine, 160 aloe-emodin 161 and curcumin. 162 The use of isolated bioactive compounds readily opted over crude extracts of plant parts since they ensure the easy availability of homogenous compounds. 163 Few studies have also highlighted the effects of polyherbal formulations as immune-boosting feed supplements in rohu.…”

Section: Phytobioticsmentioning

confidence: 99%

“…Besides, works on solvent fractionate of plant extracts have been undertaken for a few species namely Phyllanthus amarus , 153 Pedalium murex , 154 Mucuna pruriens , 155 Rauvolfia tetraphylla , 156 Andrographis paniculata 157 using aqueous, methanolic and ethanolic fractions. In addition, few studies have also worked with isolated phytochemicals like andrographolide, 158 emodin, 159 piperine, 160 aloe‐emodin 161 and curcumin 162 . The use of isolated bioactive compounds readily opted over crude extracts of plant parts since they ensure the easy availability of homogenous compounds 163 .…”

Section: Immunostimulantsmentioning

confidence: 99%

“…In a larger perspective, the research undertaken on immunomodulation in L. rohita using herbal plant extracts has revealed their possible influence on innate immune parameters such as enhancement in serum proteins and haemato‐immunological indices. Few studies also worked towards the investigation of induction of pro‐ and anti‐inflammatory cytokine gene expression levels 147,149,161,162 . Other studies documented an influence on the specific immune system marked by the enhanced production of immunoglobulins, particularly IgM, in L. rohita 144,150,159 .…”

Section: Immunostimulantsmentioning

confidence: 99%

See 3 more Smart Citations

Immunomodulation by dietary supplements: A preventive health strategy for sustainable aquaculture of tropical freshwater fish, Labeo rohita (Hamilton, 1822)

Gupta

Priyam

et al. 2021

Reviews in Aquaculture

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Dietary supplementation is an effective strategy for boosting the innate immune response in fishes. It involves the use of functional ingredients that bear the potential for mitigating the deleterious effects of chemotherapeutics (bioaccumulation and development of drug-resistant pathogens), as a more ecologically responsible approach to fish farming. With the emergence of probiotics, prebiotics, synbiotics and herbal immunostimulants; dietary supplementation has become an integral aspect of immunonutrition. In this review, we have compiled a list of dietary immunostimulants in rohu, based on the research carried over the last ten years. It should be noted that nearly 25% of the studies on dietary supplementation in Labeo rohita investigated probiotics species (either singly or as mixtures), followed by the use of herbal supplements or phytobiotics. In relation to stress, about 30% of the studies dealt with the supplementation of tryptophan, followed by the incorporation of lipotropes. Moreover, approximately 55-60% of the studies reviewed, were restricted to nutrition-based disease resistance against Aeromonas hydrophila infection. Commercially available probiotics and herbal feed additives have been helpful in the health management of L. rohita to some extent. Ongoing research is consistently exploring novel ingredients inducing favourable immunomodulation to survive stress and widespread A. hydrophila infection in L. rohita. However, further investigations aiming at broad-spectrum disease resistance and multiple stress resilience are recommended. Efforts must also be directed towards the elucidation of specifically targeted response in vivo. Overall, greater insights into the molecular mechanisms of dietary supplementation of immunostimulants warrants the use of downstream analytical techniques and highthroughput screening tools.

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