2010
DOI: 10.1124/jpet.110.168344
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Curcumin Stimulates Reactive Oxygen Species Production and Potentiates Apoptosis Induction by the Antitumor Drugs Arsenic Trioxide and Lonidamine in Human Myeloid Leukemia Cell Lines

Abstract: Arsenic trioxide (ATO, Trisenox) is an important antileukemic drug, but its efficacy is frequently low when used as a single agent. Here, we demonstrate that the apoptotic action of ATO is greatly increased when combined with subcytotoxic curcumin concentrations in U937 and HL60 human acute myeloid leukemia cells, and with lower efficacy in K562 chronic myelogenous leukemia cells. Curcumin exerts similar cooperative effect with the mitochondria-targeting drug lonidamine, whereas the response is negligible in c… Show more

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Cited by 79 publications
(61 citation statements)
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“…A number of anticancer compounds have been known to exert their anticancer effects by the generation of ROS, 52,53 which is considered as one of the key mediators of apoptotic signaling. In this connection, nanocomposite PGE-HRG-Ag-2 was evaluated for its ROS-inducing capability in A549 cells.…”
Section: Effect On Intracellular Ros Generationmentioning
confidence: 99%
“…A number of anticancer compounds have been known to exert their anticancer effects by the generation of ROS, 52,53 which is considered as one of the key mediators of apoptotic signaling. In this connection, nanocomposite PGE-HRG-Ag-2 was evaluated for its ROS-inducing capability in A549 cells.…”
Section: Effect On Intracellular Ros Generationmentioning
confidence: 99%
“…In the extrinsic pathway, anthocyanins modulate the expression of Fas and FasL (Fas ligand) in cancer cells, which result in the activation of caspase-8, then cleaves Bid to tBid, and ultimately stimulates cytochrome c release [41]. Of note, several lines of evidence have indicated that oxidative stress resulted from stimulation of ROS production and/or insufficient ROS elimination is implicated in anthocyanins-triggered apoptosis induction in cancer cells, although broad biological activities including antimutagenesis and anticarcinogenesis of anthocyanins are generally attributed to their antioxidant activity [2,7,10,[22][23][24][25]. Indeed, it has been demonstrated that the most common type of anthocyanins, cyanidin-3-rutinoside, induced apoptosis in a human myeloid leukemia cell line, HL-60, in a dose-and timedependent manner accompanied by accumulation of peroxides [10].…”
Section: Anthocyansmentioning
confidence: 99%
“…Curcumin has emerged worldwide as a potent therapeutic substance for treating diverse human diseases including various types of cancer, such as leukemia, colon cancer and pancreatic cancer [7,25,35,55,56]. Although the precise mode of action of this compound is and 100 μg/ml), luteolin (final concentrations: 0.1, 1, 10 and 20 μg/ml) or 5-FU (1, 10 and 100 μM) for 48 h, cell viability was determined by XTT dye-reduction assay according to the method described previously [53].…”
Section: Curcuminmentioning
confidence: 99%
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