Curcumin-Silk Fibroin Nanoparticles for Enhanced Anti-Candida albicans Activity In Vitro and In Vivo

Xue, Baiji; Zhang, Yuelan; Xu, Man; Wang, Chuqiao; Huang, Jinxiang; Zhang, Haoxiang; Meng, Shuhui; Xie, Maobin; Tao, Ailin; Li, Xuefeng

doi:10.1166/jbn.2019.2722

Cited by 28 publications

(22 citation statements)

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“…In an effort to increase the activity of 11, curcumin-silk fibroin nanoparticles were developed using silk fibroin (insoluble protein present in silk) as the carrier. These nanoparticles could inhibit the adhesion of C. albicans to pulmonary epithelial cells significantly compared with curcumin alone [65].…”

Section: Polyphenolsmentioning

confidence: 95%

Targeting Adhesion in Fungal Pathogen Candida Albicans

2020

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Fungal infections with increasing resistance to conventional therapies are a growing concern. Candida albicans is a major opportunistic yeast responsible for mucosal and invasive infections. Targeting the initial step of the infection process (i.e., C. albicans adhesion to the host cell) is a promising strategy. A wide variety of molecules can interfere with adhesion processes via an assortment of mechanisms. Herein, we focus on how small molecules disrupt biosynthesis of fungal cell wall components and membrane structure, prevent the localization of GPI-anchor proteins, inhibit production of enzymes involved in adhesion, downregulate genes encoding adhesins and competitively inhibit receptor interactions. As a result, adhesion of C. albicans to host cells is reduced, paving the way to new classes of antifungal agents.

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Section: Polyphenolsmentioning

confidence: 95%

Targeting Adhesion in Fungal Pathogen Candida Albicans

2020

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“…This biomaterial, when formulated as nanoparticles, has great potential as a vehicle for drugs due to its capacity to adsorb, transport and deliver a wide range of bioactive molecules [ 27 ]. Other polyphenols such as curcumin [ 25 , 28 , 29 ], naringenin [ 24 , 30 ], quercetin [ 31 ] or resveratrol [ 32 ] have been incorporated in silk fibroin nanoparticles (SFNs) and have yielded promising results in terms of enhanced antioxidant, antifungal and antitumor activities compared with the free drugs. In a previous work, our research group developed a novel procedure to produce SFNs from ionic liquid-SF solutions obtained by high-power ultrasounds [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

et al. 2021

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Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has drawn increasing attention because of its remarkable bioactive properties, including anti-inflammatory, anticancer and antibacterial activities. The aim of this study was to synthesize and characterize RA-loaded silk fibroin nanoparticles (RA-SFNs) in terms of their physical–chemical features and composition, and to investigate their antitumor activity against human cervical carcinoma and breast cancer cell lines (HeLa and MCF-7). Compared with the free form, RA bioavailability was enhanced when the drug was adsorbed onto the surface of the silk fibroin nanoparticles (SFNs). The resulting particle diameter was 255 nm, with a polydispersity index of 0.187, and the Z-potential was −17 mV. The drug loading content of the RA-SFNs was 9.4 wt.%. Evaluation of the in vitro drug release of RA from RA-SFNs pointed to a rapid release in physiological conditions (50% of the total drug content was released in 0.5 h). Unloaded SFNs exhibited good biocompatibility, with no significant cytotoxicity observed during the first 48 h against HeLa and MCF-7 cancer cells. In contrast, cell death increased in a concentration-dependent manner after treatment with RA-SFNs, reaching an IC50 value of 1.568 and 1.377 mg/mL on HeLa and MCF-7, respectively. For both cell lines, the IC50 of free RA was higher. The cellular uptake of the nanoparticles studied was increased when RA was loaded on them. The cell cycle and apoptosis studies revealed that RA-SFNs inhibit cell proliferation and induce apoptosis on HeLa and MCF-7 cell lines. It is concluded, therefore, that the RA delivery platform based on SFNs improves the antitumor potential of RA in the case of the above cancers.

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“…However, these compounds often possess low aqueous solubility and extensive systemic metabolism, leading to a low therapeutic efficiency. To this end, FNPs prove their ability as a drug delivery system, which successfully incorporate numerous natural compounds such as curcumin (Gou et al, 2019;Xue et al, 2019), quercetin (Lozano-P erez et al, 2017), alpha mangostin (Pham et al, 2019a), triptolide (Ding et al, 2017), celastrol (Ding et al, 2017), and resveratrol (Lozano-P erez et al, 2014). In general, all these drug loaded FNPs demonstrated high entrapment efficiency, controllably sustained release profiles, increased drug solubility and stability, decreased drug degradation, reduced drug unwanted toxicity, as well as retained drug therapeutic efficiency, sometimes even enhanced it (Pham et al, 2019b).…”

Section: Small Molecule Deliverymentioning

confidence: 99%

Fibroin nanoparticles: a promising drug delivery system

2020

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Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

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Curcumin-Silk Fibroin Nanoparticles for Enhanced Anti-Candida albicans Activity In Vitro and In Vivo

Cited by 28 publications

References 0 publications

Targeting Adhesion in Fungal Pathogen Candida Albicans

Targeting Adhesion in Fungal Pathogen Candida Albicans

Antitumor Activity of Rosmarinic Acid-Loaded Silk Fibroin Nanoparticles on HeLa and MCF-7 Cells

Fibroin nanoparticles: a promising drug delivery system

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