Curcumin shows excellent therapeutic effect on psoriasis in mouse model

Kang, Di; Li, Bowen; Luo, Lei; Jiang, Wenbing; Lu, Qiumin; Rong, Mingqing; Lai, Ren

doi:10.1016/j.biochi.2016.01.013

Cited by 82 publications

(51 citation statements)

References 37 publications

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“…In a psoriasis mouse model, curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17, IL-22, IFN-γ, IL-2, IL-8 and TNF-α in T cells by 30%-60% in vitro. Indeed, inflammatory factors including TNF-α, IFN-γ, IL-2, IL-12, IL-22 and IL-23 in mouse serum were decreased by curcumin treatment in vivo [57]. These observations support our hypothesis that curcumin might suppress inflammation in both acute and chronic immune nephritis via the downregulation of transcription factors such as NF-κB, which dictate the expression of proinflammatory cytokines.…”

Section: Discussionsupporting

confidence: 84%

Curcumin Attenuates Both Acute and Chronic Immune Nephritis

Marakkath

et al. 2020

IJMS

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Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the therapeutic effects of curcumin on immune-mediated renal disease in an anti-glomerular basement membrane (GBM) model (representing acute kidney Injury, AKI) and murine lupus model (representing chronic kidney disease, CKD). In the AKI model, female anti-GBM 129/svj mice were administered with curcumin right before disease induction. In the CKD model, female MRL.lpr mice at the age of 8-10 weeks old were treated with curcumin or placebo via oral gavage daily for two months. After treatment, serum autoantibody levels, splenomegaly and spleen cellularity were reduced in murine lupus. Collectively, curcumin ameliorated kidney disease in the two mouse models with either acute or chronic nephritis, as marked by reduced proteinuria, blood urea nitrogen, glomerulonephritis, crescent formation, tubule-interstitial disease, and renal infiltration by lymphocytes. In addition, curcumin treatment reduced activation of the NFkB, MAPK, AKT and pBAD pathways either systemically, or within the inflamed kidneys. These findings suggest that natural food supplements could become an alternative approach to ameliorating immune-mediated kidney diseases.

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Section: Discussionsupporting

confidence: 84%

Curcumin Attenuates Both Acute and Chronic Immune Nephritis

Marakkath

et al. 2020

IJMS

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“…Different result in our study probably due to different vehicle and treatment duration. On the other hand, Kang et al 15 concluded that curcumin showed excellent therapeutic effect against psoriasis in mouse model. Similar result was also found in the lesions treated with placebo.…”

Section: Discussionmentioning

confidence: 99%

A double-blind randomized controlled trial of topical <em>Curcuma xanthorrhiza</em> Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

et al. 2018

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Background: Curcuma xanthorrhiza Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of C. xanthorrhiza in psoriasis.Methods: From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% C. xanthorrhiza ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).Results: The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% C. xanthorrhiza ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% C. xanthorrhiza ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with C. xanthorrhiza and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% C. xanthorrhiza ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).Conclusion: Based on the results, 1% C. xanthorrhiza ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. C. xanthorrhiza ointment is safe for topical administration as there were no side effects reported in this study.

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“…Some reports on the inhibitory activity of curcumin suggest that its action on the potassium channel subtype Kv1.3 in T cells plays a central role in psoriasis (Kang et al, ; H. Liu et al, ). Recently, Kang et al () showed that generation of T‐cell inflammatory factors, such as IL‐17, IL‐22, IFN‐γ, IL‐2, IL‐8, and TNF‐α, decreased by 30–60% in mice with psoriasis‐like diseases after 20 days of oral curcumin. Over 50% of T‐cell proliferation was interrupted by application of a 100‐μM curcumin preparation, and curcumin significantly decreased the signs of psoriasis and improved the condition of the skin.…”

Section: Psoriasis Treatmentmentioning

confidence: 99%

Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review

Panahi

Fazlolahzadeh

Atkin

et al. 2018

Journal Cellular Physiology

166

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Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti-inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability. In this regard, the present review is focused on recent studies concerning the use of curcumin for the treatment of skin diseases, as well as offering new and efficient strategies to optimize its pharmacokinetic profile and increase its bioavailability.

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Curcumin shows excellent therapeutic effect on psoriasis in mouse model

Cited by 82 publications

References 37 publications

Curcumin Attenuates Both Acute and Chronic Immune Nephritis

Curcumin Attenuates Both Acute and Chronic Immune Nephritis

A double-blind randomized controlled trial of topical <em>Curcuma xanthorrhiza</em> Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions

Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review

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