Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study

Ng, Tze‐Pin; Nyunt, Shwe Zin; Gwee, Xinyi; Chua, Denise Qian Ling; Yap, Keng Bee

doi:10.1007/s11357-023-00842-1

Cited by 1 publication

(2 citation statements)

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“…Our results demonstrate that curcumin has a significant impact on extending the lifespan of postmitotic cells during chronological aging. These findings align with previous studies that have highlighted the beneficial effects of curcumin on healthspan and cellular longevity 26,27,37–39 . Notably, curcumin’s anti-aging effects exhibit a biphasic dose-response pattern, with lower concentrations showing greater efficacy.…”

Section: Discussionsupporting

confidence: 92%

“…Two groundbreaking observational cohort studies conducted among middle-aged and older Asian adults living in Singapore have revealed an intriguing connection between the consumption of curcumin-rich foods and healthspan 26,27 . This study represents the inaugural longitudinal exploration of the cognitive advantages linked to curcumin obtained from natural dietary sources in human subjects.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin extends the lifespan of aging postmitotic cells with mitochondrial dysfunction

Naaz,

Zhang,

Faidzinn

et al. 2023

Preprint

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Aging is an inevitable biological process intricately linked to age-related diseases, including cardiovascular diseases, neurodegeneration, sarcopenia, and age-related macular degeneration. These ailments are often exacerbated by mitochondrial dysfunction, which plays a pivotal role in postmitotic cells. Curcumin, a natural compound, is explored for its anti-aging potential. This study explores the influence of curcumin on the postmitotic cellular lifespan (PoMiCL) of yeast during chronological aging, examining its potential implications for age-related diseases. Our findings reveal that curcumin significantly extends the lifespan of postmitotic wildtype yeast cells, with maximal effects observed at lower concentrations, displaying a hormetic response. Importantly, curcumin mitigates accelerated aging in cells afflicted by mitochondrial dysfunction. Intriguingly, the hormetic effect is absent under these conditions. Mechanistically, curcumin enhances ATP levels but induces oxidative stress and inhibits TORC1. These findings shed light on curcumin's potential as an anti-aging modulator and its relevance to age-related diseases, offering insights into novel therapeutic approaches for healthy aging while highlighting the context-dependent nature of its effects.

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