2011
DOI: 10.1016/j.neulet.2011.02.030
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Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

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Cited by 117 publications
(70 citation statements)
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“…In addition, it has been shown that corticosterone treatment caused a significant decrease in BDNF protein and mRNA expression in rat brain, while antidepressants treatment significantly increased BDNF expression in corticosterone-treated rats (Dwivedi et al 2006;Huang et al 2011). Previous in vitro studies have also demonstrated that corticosterone treatment significantly decrease BDNF mRNA expression in the primary cultured hippocampal neurons as well as PC12 cells, which could be reversed by antidepressants (Li et al 2007b;Zheng et al 2011).…”
Section: Discussionmentioning
confidence: 97%
“…In addition, it has been shown that corticosterone treatment caused a significant decrease in BDNF protein and mRNA expression in rat brain, while antidepressants treatment significantly increased BDNF expression in corticosterone-treated rats (Dwivedi et al 2006;Huang et al 2011). Previous in vitro studies have also demonstrated that corticosterone treatment significantly decrease BDNF mRNA expression in the primary cultured hippocampal neurons as well as PC12 cells, which could be reversed by antidepressants (Li et al 2007b;Zheng et al 2011).…”
Section: Discussionmentioning
confidence: 97%
“…In fact, the model of depression induced by chronic administration of CORT induces behavioral alterations that resemble depression (Zhao et al, 2008). Studies show that animals submitted to this model present a depressive-like phenotype as observed by the increases in immobility time in the FST and tail suspension test (TST), anxiety-like phenotype as observed by decrease in the open arms entries in the plus maze test and anhedonic-like phenotype represented by reduce in sucrose consumption in SPT (Zhao et al, 2008;Huang et al, 2011;Silva et al, 2013), corroborating with data of current study.…”
Section: Discussionmentioning
confidence: 99%
“…These have consistently demonstrated that both acute (Arora et al, 2011;Chimakurthy and Talasila, 2010;Gilhotra and Dhingra, Antidepressant Potential Modes of Action of Curcumin 2010; Kulkarni et al, 2008;Sanmukhani et al, 2011;Wang et al, 2008) and chronic (Bhutani et al, 2009;Huang et al, 2011;Li et al, 2009;Sanmukhani et al, 2011;Xia et al, 2007;Xu et al, 2005b) administration of curcumin to rats and mice reduces immobility time.…”
Section: Antidepressant Effects Of Curcumin In Animal Modelsmentioning
confidence: 95%