Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis

Xiao, Qiuping; Zhong, You-Bao; Kang, Zeng-Ping; Huang, Jiaqi; Fang, Weiyan; Sun, Wei; Long, Jian; Li, Shanshan; Zhao, Hai-Mei; Liu, Duan-Yong

doi:10.1002/ptr.7404

Cited by 29 publications

(15 citation statements)

References 81 publications

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“…Resveratrol increased the relative abundance of Allobaculum , Olsenella , and Enterorhabdus genera and simultaneously decreased the relative abundance of Anaerotruncus , Clostridium XlVb , and Flavonifractor genera in HFD-fed mice . Moreover, curcumin could attenuate mucosal ulcers and hyperglycaemia in T2DM mice with ulcerative colitis . Curcumin inhibited the response of Th17 cells and promoted the differentiation of Treg cells.…”

Section: Natural Products Targeting the Gut Microbiota In Dmmentioning

confidence: 95%

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Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Jiang

Sun

Zhou

2022

J. Agric. Food Chem.

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Diabetes mellitus (DM) is a serious metabolic disease characterized by persistent hyperglycemia, with a continuously increasing morbidity and mortality. Although traditional treatments including insulin and oral hypoglycemic drugs maintain blood glucose levels within the normal range to a certain extent, there is an urgent need to develop new drugs that can effectively improve glucose metabolism and diabetes-related complications. Notably, accumulated evidence implicates that the gut microbiota is unbalanced in DM individuals and is involved in the physiological and pathological processes of this metabolic disease. In this review, we introduce the molecular mechanisms by which the gut microbiota contributes to the development of DM. Furthermore, we summarize the preclinical studies of bioactive natural products that exert antidiabetic effects by modulating the gut microbiota, aiming to expand the novel therapeutic strategies for DM prevention and management.

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Section: Natural Products Targeting the Gut Microbiota In Dmmentioning

confidence: 95%

“…109 Moreover, curcumin could attenuate mucosal ulcers and hyperglycaemia in T2DM mice with ulcerative colitis. 110 Curcumin inhibited the response of Th17 cells and promoted the differentiation of Treg cells. Meanwhile, it regulated the abundance of norank_f_Ruminococcaceae, Monoglobus, and Candidatus_Saccharimonas at the genus level.…”

Section: Microbiota In Dmmentioning

confidence: 99%

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Jiang

Sun

Zhou

2022

J. Agric. Food Chem.

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“…Based on our existing research results, there are still some problems to be solved, the first of which is how sex determines the intestinal flora composition. In addition to the widely discussed sex hormones, a sex bias has also been found in the Th17/Treg cell ratio, which is closely related to intestinal microbiota homeostasis [ 64 , 65 ] and may be a potential interfering factor. Second, the specific mechanism by which dysbacteriosis affects neuroinflammation needs to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation

Wang

Zhong

Zhu

et al. 2022

J Neuroinflammation

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Background and purpose Stroke is associated with high disability and mortality rates and increases the incidence of organ-related complications. Research has revealed that the outcomes and prognosis of stroke are regulated by the state of the intestinal microbiota. However, the possibility that the manipulation of the intestinal microbiota can alter sex-related stroke outcomes remain unknown. Methods To verify the different effects of microbiota from different sexes on stroke outcomes, we performed mouse fecal microbiota transplantation (FMT) and established a model of ischemic stroke. Male and female mice received either male or female microbiota through FMT. Ischemic stroke was triggered by MCAO (middle cerebral artery occlusion), and sham surgery served as a control. Over the next few weeks, the mice underwent neurological evaluation and metabolite and inflammatory level detection, and we collected fecal samples for 16S ribosomal RNA analysis. Results We found that when the female mice were not treated with FMT, the microbiota (especially the Firmicutes-to-Bacteroidetes ratio) and the levels of three main metabolites tended to resemble those of male mice after experimental stroke, indicating that stroke can induce an ecological imbalance in the biological community. Through intragastric administration, the gut microbiota of male and female mice was altered to resemble that of the other sex. In general, in female mice after MCAO, the survival rate was increased, the infarct area was reduced, behavioral test performance was improved, the release of beneficial metabolites was promoted and the level of inflammation was mitigated. In contrast, mice that received male microbiota were much more hampered in terms of protection against brain damage and the recovery of neurological function. Conclusion A female-like biological community reduces the level of systemic proinflammatory cytokines after ischemic stroke. Poor stroke outcomes can be positively modulated following supplementation with female gut microbiota.

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“…Curcumin could effectively inhibit the occurrence and development of DSS-induced UC and alleviate the disease. In DSS-induced colitis models, curcumin significantly increased the body weight and colon length, decreased the colon weight, colon mass index, and DAI score, and effectively improved histopathological damage in colitis mice ( Zhang et al, 2019 ; Kang et al, 2021b ; Xiao et al, 2022 ). Additionally, curcumin significantly reduced the levels of proinflammatory cytokines, including TNF-α, IL-1β, IL-6, CCL-2, and IL-17A, and significantly increased the levels of anti-inflammatory cytokines, including IL-33 and IL-10 ( Zhang et al, 2019 ; Kang et al, 2021b ; Xiao et al, 2022 ).…”

Section: Tcm Alleviates Uc By Regulating Macrophage Polarizationmentioning

confidence: 98%

“…In DSS-induced colitis models, curcumin significantly increased the body weight and colon length, decreased the colon weight, colon mass index, and DAI score, and effectively improved histopathological damage in colitis mice ( Zhang et al, 2019 ; Kang et al, 2021b ; Xiao et al, 2022 ). Additionally, curcumin significantly reduced the levels of proinflammatory cytokines, including TNF-α, IL-1β, IL-6, CCL-2, and IL-17A, and significantly increased the levels of anti-inflammatory cytokines, including IL-33 and IL-10 ( Zhang et al, 2019 ; Kang et al, 2021b ; Xiao et al, 2022 ). About M1/M2 Macrophage Polarization, Kang, et al ( Kang et al, 2021b ) the research found that curcumin significantly downregulated the percentage of M1 macrophage CD11b + F4/80 + iNOS + in colitis mice and significantly upregulated the percentage of M2 macrophage CD11b + F4/80 + CD206 + and CD11b + F4/80 + CD163 + macrophages, suggesting curcumin interfering with the process of experimental colitis effectively by regulating the balance of M1/M2 macrophage polarization.…”

Section: Tcm Alleviates Uc By Regulating Macrophage Polarizationmentioning

confidence: 98%

A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization

et al. 2022

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Intestinal macrophages are the main participants of intestinal immune homeostasis and intestinal inflammation. Under different environmental stimuli, intestinal macrophages can be polarized into classical activated pro-inflammatory phenotype (M1) and alternative activated anti-inflammatory phenotype (M2). Its different polarization state is the “guide” to promoting the development and regression of inflammation. Under normal circumstances, intestinal macrophages can protect the intestine from inflammatory damage. However, under the influence of some genetic and environmental factors, the polarization imbalance of intestinal M1/M2 macrophages will lead to the imbalance in the regulation of intestinal inflammation and transform the physiological inflammatory response into pathological intestinal injury. In UC patients, the disorder of intestinal inflammation is closely related to the imbalance of intestinal M1/M2 macrophage polarization. Therefore, restoring the balance of M1/M2 macrophage polarization may be a potentially valuable therapeutic strategy for UC. Evidence has shown that traditional Chinese medicine (TCM) has positive therapeutic effects on UC by restoring the balance of M1/M2 macrophage polarization. This review summarizes the clinical evidence of TCM for UC, the vital role of macrophage polarization in the pathophysiology of UC, and the potential mechanism of TCM regulating macrophage polarization in the treatment of UC. We hope this review may provide some new enlightenment for the clinical treatment, fundamental research, and research and development of new Chinese medicine of UC.

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Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis

Cited by 29 publications

References 81 publications

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation

A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization

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