Curcumin Reduces Burn Progression in Rats

Abstract

Pretreatment of rats with oral curcumin followed by once-daily oral treatment for three days reduced the percentage of unburned skin interspaces that progressed to full necrosis.

Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: a pilot study

“…19 True to this accreditation, turmeric has been shown to be useful in the treatment of various skin diseases, inflammation, abscess, eczema, leucoderma, bruises, wounds, urticaria, psoriasis and acne. 19 Scientific studies carried out during the past three decades have shown that turmeric and its chief phytochemical curcumin possess wound-healing, [20][21][22][23][24][25][26][27][28][29][30] anti-ageing, 31,32 anti-psoriatic [33][34][35] properties and are also effective against UV-induced skin damage [36][37][38][39][40] and chemical carcinogenesis [41][42][43][44][45][46] and provide remarkable symptomatic relief for cancer patients when applied topically. 47 Clinical studies have shown that daily intake of 6 g of curcumin during the course of radiotherapy reduces the severity of radiation dermatitis in patients with breast cancer.…”

The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer

“…65 Additionally, the investigators have also observed that repetitive exposure to curcumin caused recurring suppression of cytokine/ chemokine expression. 65 Turmeric has been used as a wound healing agent for centuries [32][33][34][35] and animal studies have shown that when compared with untreated controls, the application of curcumin enhances faster wound closure of punch wounds in curcumin-treated animals. 37 Histopathological observations indicate that in the cohorts where turmeric was applied, increased levels of reepithelialization of epidermis; migration of myofibroblasts, fibroblasts, and macrophages to the wound bed; promotion of neovascularization and greater deposition of collagen was pronounced and that this effect was mediated by increased levels of transforming growth factor-β1.…”

“…[19][20][21][22][23] Studies have also shown that they are effective in preventing the side effects of anticancer drugs [24][25][26][27] and ionizing radiation. [28][29][30][31] Turmeric is a frontline wound healing agent in the various traditional systems of medicine and experiments have also shown that turmeric/curcumin were effective in healing wound in different conditions, [32][33][34][35] including that of wounds created in mice previously exposed to γ-radiation. [36][37][38][39] With respect to clinical studies, turmeric is shown to be effective as a mouthwash and to possess antiplaque, antiinflammatory, and antimicrobial properties.…”

Topical Curcumin for the Healing of Carbon Dioxide Laser Skin Wounds in Mice

“…We decided to use curcumin in accordance with the studies of Sidhu et al 11 and Singer et al 16 This substance been shown to enhance wound healing in a mouse model of full-thickness injuries. Curcumin-treated biopsy wounds showed an increased presence of neutrophils, macrophages, and fibroblasts.…”

“…[12][13][14] Curcumin has been reported to be effective in wound repair in normal and diabetes-impaired healing, when used both orally and topically. 12 It exerts inhibitory activity against hydrogen peroxide-induced oxidative damage in human keratinocytes and fibroblasts, 15,16 and has also been reported to have potent antioxidant activity [12][13][14][15][16] and to confer protection against irradiation in vitro and in vivo. 13,17 Some articles 18,19 have shown that curcumin-treated wounds heal much faster as indicated by improved rates of epithelialization, wound contraction, greater deposition of collagen, and an increase in transforming growth factor b-1.…”