Curcumin protects the dorsal root ganglion and sciatic nerve after crush in rat

Noorafshan, Ali; Omidi, Abdollah; Karbalay‐Doust, Saied

doi:10.1016/j.prp.2011.06.011

Cited by 32 publications

(24 citation statements)

References 27 publications

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“…In contrast to the central nervous system, peripheral nerves are able to regenerate injury 13 . Axonotmesis can be seen after crush A recent publication has shown that MPS treatment was associated with mild neuroprotection without improvement of functional recovery 19 .…”

Section: Discussionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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PURPOSE:To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS:Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006).Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II. CONCLUSION:The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.

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Section: Discussionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

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“…In the present study, curcumin significantly improved the SFI index which indicates its potential neuroprotective action against vincristine. Further, it has been recently reported that curcumin promotes nerve regeneration and functional recovery in the rat model of sciatic nerve crush injury (Noorafshan et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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“…Our study confirmed these findings, as there were signs of regeneration in all biopsies. If polyneuropathy is diagnosed early, initiation of early immunosuppressive treatment to prevent loss of nerve axons is recommended and so is the use of neuroprotective drugs [38].…”

Section: Polyneuropathy In Crohn Diseasementioning

confidence: 99%