Curcumin Protects Nigrostriatal Dopaminergic Neurons and Reduces Glial Activation in 6-Hydroxydopamine Hemiparkinsonian Mice Model

Tripanichkul, Wanida; Jaroensuppaperch, Em-orn

doi:10.3109/00207454.2011.648760

Cited by 32 publications

(18 citation statements)

References 20 publications

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“…Curcumin has extended neuroprotection in a rat model of PD against 6-hydroxydopamine treatment through its iron chelating activity and reduced degeneration of neurons [182]. Similarly, curcumin's ability to reverse neurodegeneration in hemi-Parkinson's mice model has been shown [183]. Apart from iron chelation, NF κ B modulation by curcumin has also contributed to the reduction in 6-OHDA-induced neurodegeneration [184].…”

Section: Polyphenols and Metal Ion Chelationmentioning

confidence: 99%

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Bhullar

Rupasinghe

2013

Oxidative Medicine and Cellular Longevity

347

194

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Aging leads to numerous transitions in brain physiology including synaptic dysfunction and disturbances in cognition and memory. With a few clinically relevant drugs, a substantial portion of aging population at risk for age-related neurodegenerative disorders require nutritional intervention. Dietary intake of polyphenols is known to attenuate oxidative stress and reduce the risk for related neurodegenerative diseases such as Alzheimer's disease (AD), stroke, multiple sclerosis (MS), Parkinson's disease (PD), and Huntington's disease (HD). Polyphenols exhibit strong potential to address the etiology of neurological disorders as they attenuate their complex physiology by modulating several therapeutic targets at once. Firstly, we review the advances in the therapeutic role of polyphenols in cell and animal models of AD, PD, MS, and HD and activation of drug targets for controlling pathological manifestations. Secondly, we present principle pathways in which polyphenol intake translates into therapeutic outcomes. In particular, signaling pathways like PPAR, Nrf2, STAT, HIF, and MAPK along with modulation of immune response by polyphenols are discussed. Although current polyphenol researches have limited impact on clinical practice, they have strong evidence and testable hypothesis to contribute clinical advances and drug discovery towards age-related neurological disorders.

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Section: Polyphenols and Metal Ion Chelationmentioning

confidence: 99%

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Bhullar

Rupasinghe

2013

Oxidative Medicine and Cellular Longevity

347

194

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“…As found for Aβ, curcumin can also inhibit the aggregation of α-synuclein (131), and several studies performed in rodents have examined the neuroprotective potential of curcuminoids against both MPTP- and 6-OHDA-induced dopaminergic degeneration. In these studies, orally and intravenously administered curcumin modulates dopaminergic damage in 6-OHDA-treated rodents by suppressing apoptosis and inducing microglial activation with a consequent improvement in locomotion (132, 133). Dietary, intravenous and intraperitoneal curcumin administration reversed the dopaminergic neurotoxicity in MPTP-treated rodents.…”

Section: Effect Of Curcumin In Mammalsmentioning

confidence: 99%

Curcumin and neurodegenerative diseases

2013

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Over the last ten years curcumin has been reported to be effective against a wide variety of diseases and is characterized as having anti-carcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, anti-arthritic, and anti-infectious properties. Recent studies performed in both vertebrate and invertebrate models have been conducted to determine whether curcumin was also neuroprotective. The efficacy of curcumin in several pre-clinical trials for neurodegenerative diseases has created considerable excitement mainly due to its lack of toxicity and low cost. This suggests that curcumin could be a worthy candidate for nutraceutical intervention. Since aging is a common risk factor for neurodegenerative diseases, it is possible that some compounds that target aging mechanisms could also prevent these kinds of diseases. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent aging-associated changes in cellular proteins that lead to protein insolubility and aggregation. This loss in protein homeostasis is associated with several age-related diseases. Recently, curcumin has been found to help maintain protein homeostasis and extend lifespan in the model invertebrate Caenorhabditis elegans. Here, we review the evidence from several animal models that curcumin improves healthspan by preventing or delaying the onset of various neurodegenerative diseases.

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“…The neuroprotection was accompanied with a significant weakening of astroglial and microglial reaction in the striatum and the substantia nigra pars compacta (SNpc). These results indicate that the neuroprotective effects of curcumin in 6-OHDA-lesioned mice may be mediated via its antiinflammatory properties, or direct protection on nigral DA neurons [45]. …”

Section: Neuroprotective Activity Of Bioactive Compounds From Herbmentioning

confidence: 99%

Advances in Neuroprotective Ingredients of Medicinal Herbs by Using Cellular and Animal Models of Parkinson’s Disease

Kumar

Kang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Parkinson's disease (PD) is a multifactorial disorder, which is neuropathologically identified by age-dependent neurodegeneration of dopaminergic neurons in the substantia nigra. Development of symptomatic treatments has been partly successful for PD research, but there remain a number of inadequacies in therapeutic strategies for the disease. The pathogenesis of PD remains intricate, and the present anti-PD treatments appears to be clinically insufficient. Comprehensive research on discovery of novel drug candidates has demonstrated that natural products, such as medicinal herbs, plant extracts, and their secondary metabolites, have great potential as therapeutics with neuroprotective activity in PD. Recent preclinical studies suggest that a number of herbal medicines and their bioactive ingredients can be developed into optimum pharmaceuticals for treating PD. In many countries, traditional herbal medicines are used to prevent or treat neurodegenerative disorders, and some have been developed as nutraceuticals or functional foods. Here we focus on recent advances of the evidence-linked neuroprotective activity of bioactive ingredients of herbal origin in cellular and animal models of PD research.

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Curcumin Protects Nigrostriatal Dopaminergic Neurons and Reduces Glial Activation in 6-Hydroxydopamine Hemiparkinsonian Mice Model

Cited by 32 publications

References 20 publications

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Curcumin and neurodegenerative diseases

Advances in Neuroprotective Ingredients of Medicinal Herbs by Using Cellular and Animal Models of Parkinson’s Disease

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